1
|
Rivera GA and Wakelee H: Lung Cancer in
never smokers. Adv Exp Med Biol. 893:43–57. 2016. View Article : Google Scholar : PubMed/NCBI
|
2
|
Garon EB, Hellmann MD, Rizvi NA, Carcereny
E, Leighl NB, Ahn MJ, Eder JP, Balmanoukian AS, Aggarwal C, Horn L,
et al: Five-year overall survival for patients with advanced
non-small-cell lung cancer treated with pembrolizumab: Results from
the phase I KEYNOTE-001 study. J Clin Oncol. 37:2518–2527. 2019.
View Article : Google Scholar : PubMed/NCBI
|
3
|
Chiang AC and Herbst RS: Frontline
immunotherapy for NSCLC-the tale of the tail. Nat Rev Clin Oncol.
17:73–74. 2020. View Article : Google Scholar : PubMed/NCBI
|
4
|
Wu L, Wang L, Tian X, Zhang J and Feng H:
Germacrone exerts anti-cancer effects on gastric cancer through
induction of cell cycle arrest and promotion of apoptosis. BMC
Complement Med Ther. 20:212020. View Article : Google Scholar : PubMed/NCBI
|
5
|
Chen QF, Wang G, Tang LQ, Yu XW, Li ZF and
Yang XF: Effect of germacrone in alleviating HUVECs damaged by
H2O2-induced oxidative stress. Zhongguo Zhong Yao Za Zhi.
42:3564–3571. 2017.(In Chinese). PubMed/NCBI
|
6
|
Wang Z, Zhuo F, Chu P, Yang X and Zhao G:
Germacrone alleviates collagen-induced arthritis via regulating
Th1/Th2 balance and NF-κB activation. Biochem Biophys Res Commun.
518:560–564. 2019. View Article : Google Scholar : PubMed/NCBI
|
7
|
Nair A, Amalraj A, Jacob J, Kunnumakkara
AB and Gopi S: Non-curcuminoids from turmeric and their potential
in cancer therapy and anticancer drug delivery formulations.
Biomolecules. 9:132019. View Article : Google Scholar : PubMed/NCBI
|
8
|
Yu Z, Xu J, Shao M and Zou J: Germacrone
induces apoptosis as well as protective autophagy in human prostate
cancer cells. Cancer Manag Res. 12:4009–4016. 2020. View Article : Google Scholar : PubMed/NCBI
|
9
|
Zhong Z, Chen X, Tan W, Xu Z, Zhou K, Wu
T, Cui L and Wang Y: Germacrone inhibits the proliferation of
breast cancer cell lines by inducing cell cycle arrest and
promoting apoptosis. Eur J Pharmacol. 667:50–55. 2011. View Article : Google Scholar : PubMed/NCBI
|
10
|
An JF, Sun Y, Zhang QL, Zhang FL and Zhang
JL: The effects of germacrone on lipopolysaccharide-induced acute
lung injury in neonatal rats. Cell Mol Biol (Noisy-le-Grand).
60:8–12. 2014.PubMed/NCBI
|
11
|
Hashem S, Nisar S, Sageena G, Macha MA,
Yadav SK, Krishnankutty R, Uddin S, Haris M and Bhat AA:
Therapeutic effects of curcumol in several diseases; An overview.
Nutr Cancer. 73:181–195. 2021. View Article : Google Scholar : PubMed/NCBI
|
12
|
Xu W, Gao L, Li T, Zheng J, Shao A and
Zhang J: Mesencephalic astrocyte-derived Neurotrophic factor (MANF)
protects against neuronal apoptosis via activation of Akt/MDM2/p53
signaling pathway in a rat model of intracerebral hemorrhage. Front
Mol Neurosci. 11:1762018. View Article : Google Scholar : PubMed/NCBI
|
13
|
Gao J, Xia R, Chen J, Gao J, Luo X, Ke C,
Ren C, Li J and Mi Y: Inhibition of esophageal-carcinoma cell
proliferation by genistein via suppression of JAK1/2-STAT3 and
AKT/MDM2/p53 signaling pathways. Aging (Albany NY). 12:6240–6259.
2020. View Article : Google Scholar : PubMed/NCBI
|
14
|
Chen H, Zhou L, Wu X, Li R, Wen J, Sha J
and Wen X: The PI3K/AKT pathway in the pathogenesis of prostate
cancer. Front Biosci (Landmark Ed). 21:1084–1091. 2016. View Article : Google Scholar : PubMed/NCBI
|
15
|
Iida M, Harari PM, Wheeler DL and Toulany
M: Targeting AKT/PKB to improve treatment outcomes for solid
tumors. Mutat Res. 819-820:1116902020. View Article : Google Scholar : PubMed/NCBI
|
16
|
Song M, Bode AM, Dong Z and Lee MH: AKT as
a therapeutic target for cancer. Cancer Res. 79:1019–1031. 2019.
View Article : Google Scholar : PubMed/NCBI
|
17
|
Reyes-Farias M and Carrasco-Pozo C: The
Anti-Cancer Effect of Quercetin: Molecular implications in cancer
metabolism. Int J Mol Sci. 20:31772019. View Article : Google Scholar : PubMed/NCBI
|
18
|
Chen G, Park D, Magis AT, Behera M,
Ramalingam SS, Owonikoko TK, Sica GL, Ye K, Zhang C, Chen Z, et al:
Mcl-1 Interacts with Akt to promote lung cancer progression. Cancer
Res. 79:6126–6138. 2019. View Article : Google Scholar : PubMed/NCBI
|
19
|
Mayo LD and Donner DB: A
phosphatidylinositol 3-kinase/Akt pathway promotes translocation of
Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA.
98:11598–11603. 2001. View Article : Google Scholar : PubMed/NCBI
|
20
|
Xie XH, Zhao H, Hu YY and Gu XD:
Germacrone reverses Adriamycin resistance through cell apoptosis in
multidrug-resistant breast cancer cells. Exp Ther Med. 8:1611–1615.
2014. View Article : Google Scholar : PubMed/NCBI
|
21
|
Liu B, Gao YQ, Wang XM, Wang YC and Fu LQ:
Germacrone inhibits the proliferation of glioma cells by promoting
apoptosis and inducing cell cycle arrest. Mol Med Rep.
10:1046–1050. 2014. View Article : Google Scholar : PubMed/NCBI
|
22
|
He W, Zhai X, Su J, Ye R, Zheng Y and Su
S: Antiviral Activity of Germacrone against Pseudorabies Virus in
vitro. Pathogens. 8:2582019. View Article : Google Scholar : PubMed/NCBI
|
23
|
Cai F, Chen M, Zha D, Zhang P, Zhang X,
Cao N, Wang J, He Y, Fan X, Zhang W, et al: Curcumol potentiates
celecoxib-induced growth inhibition and apoptosis in human
non-small cell lung cancer. Oncotarget. 8:115526–115545. 2017.
View Article : Google Scholar : PubMed/NCBI
|
24
|
Revathidevi S and Munirajan AK: Akt in
cancer: Mediator and more. Semin Cancer Biol. 59:80–91. 2019.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Abraham AG and O'Neill E:
PI3K/Akt-mediated regulation of p53 in cancer. Biochem Soc Trans.
42:798–803. 2014. View Article : Google Scholar : PubMed/NCBI
|
26
|
van Oijen MG and Slootweg PJ:
Gain-of-function mutations in the tumor suppressor gene p53. Clin
Cancer Res. 6:2138–2145. 2000.PubMed/NCBI
|
27
|
Flemming A: Cancer: Mutant p53 rescued by
aggregation inhibitor. Nat Rev Drug Discov. 15:852016. View Article : Google Scholar : PubMed/NCBI
|
28
|
Han CT, Schoene NW and Lei KY: Influence
of zinc deficiency on Akt-Mdm2-p53 and Akt-p21 signaling axes in
normal and malignant human prostate cells. Am J Physiol Cell
Physiol. 297:C1188–C1199. 2009. View Article : Google Scholar : PubMed/NCBI
|
29
|
Lim MS, Choung SY and Jeong KW: Germacrone
inhibits estrogen receptor α-mediated transcription in MCF-7 breast
cancer cells. Phytother Res. 30:2036–2043. 2016. View Article : Google Scholar : PubMed/NCBI
|
30
|
Kong Q, Ma Y, Yu J and Chen X: Predicted
molecular targets and pathways for germacrone, curdione, and
furanodiene in the treatment of breast cancer using a
bioinformatics approach. Sci Rep. 7:155432017. View Article : Google Scholar : PubMed/NCBI
|
31
|
Wu T, Yin F, Kong H and Peng J: Germacrone
attenuates cerebral ischemia/reperfusion injury in rats via
antioxidative and antiapoptotic mechanisms. J Cell Biochem.
120:18901–18909. 2019. View Article : Google Scholar : PubMed/NCBI
|