Open Access

Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes

  • Authors:
    • Xu-Lan Wang
    • Wei Zhang
    • Zhe Li
    • Wen-Qi Han
    • Hao-Yu Wu
    • Qun-Rang Wang
    • Xin-Hong Liu
    • Kun Xing
    • Gong Cheng
    • Feng-Jun Chang
  • View Affiliations

  • Published online on: April 21, 2021     https://doi.org/10.3892/mmr.2021.12113
  • Article Number: 474
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As a common factor of both type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS), circulating microparticles (MPs) may provide a link between these two diseases. The present study compared the content and function of MPs from patients with ACS with or without T2DM. MPs from healthy subjects (n=20), patients with ACS (n=24), patients with T2DM (n=20) and patients with combined ACS and T2DM (n=24) were obtained. After incubating rat thoracic tissue with MPs, the effect of MPs on endothelial‑dependent vasodilatation, expression of caveolin‑1 and endothelial nitric oxide synthase (eNOS), phosphorylation of eNOS at the S1177 and T495 sites and its association with heat shock protein 90 (Hsp90), and the generation of NO and superoxide anion (O2˙‑) were determined. MP concentrations were higher in patients with T2DM and patients with ACS with or without T2DM than in healthy subjects. Moreover, MPs from patients with T2DM or ACS led to impairment in endothelial‑dependent vasodilatation, decreased expression of NO, as well as eNOS and its phosphorylation at Ser1177 and association with Hsp90, but increased eNOS phosphorylation at T495, caveolin‑1 expression and O2˙‑ generation. These effects were strengthened by MPs from patients with ACS combined with T2DM. T2DM not only increased MP content but also resulted in greater vascular impairment effects in ACS. These results may provide novel insight into the treatment of patients with ACS and T2DM.
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June-2021
Volume 23 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang X, Zhang W, Li Z, Han W, Wu H, Wang Q, Liu X, Xing K, Cheng G, Chang F, Chang F, et al: Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes. Mol Med Rep 23: 474, 2021.
APA
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q. ... Chang, F. (2021). Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes. Molecular Medicine Reports, 23, 474. https://doi.org/10.3892/mmr.2021.12113
MLA
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q., Liu, X., Xing, K., Cheng, G., Chang, F."Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes". Molecular Medicine Reports 23.6 (2021): 474.
Chicago
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q., Liu, X., Xing, K., Cheng, G., Chang, F."Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes". Molecular Medicine Reports 23, no. 6 (2021): 474. https://doi.org/10.3892/mmr.2021.12113