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Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs

  • Authors:
    • Rachel Kerslake
    • Harpal S. Randeva
    • Danny Jonigk
    • Christopher Werlein
    • Jan L. Robertus
    • Periklis Katopodis
    • Petra Jasker
    • Demetrios A. Spandidos
    • Ioannis Kyrou
    • Emmanouil Karteris

  • View Affiliations

  • Published online on: February 24, 2022     https://doi.org/10.3892/mmr.2022.12654
  • Article Number: 138

  • Copyright: © Kerslake et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In addition to the angiotensin‑converting enzyme 2 (ACE2), a number of host cell entry mediators have been identified for severe acute respiratory syndrome coronavirus‑2 (SARS‑CoV‑2), including transmembrane protease serine 4 (TMPRSS4). The authors have recently demonstrated the upregulation of TMPRSS4 in 11 different cancers, as well as its specific expression within the central nervous system using in silico tools. The present study aimed to expand the initial observations and, using immunohistochemistry, TMPRSS4 protein expression in the gastrointestinal (GI) tract and lungs was further mapped. Immunohistochemistry was performed on tissue arrays and lung tissues of patients with non‑small cell lung cancer with concurrent coronavirus disease 2019 (COVID‑19) infection using TMPRSS4 antibody. The results revealed that TMPRSS4 was abundantly expressed in the oesophagus, stomach, small intestine, jejunum, ileum, colon, liver and pancreas. Moreover, the extensive TMPRSS4 protein expression in the lungs of a deceased patient with COVID‑19 with chronic obstructive pulmonary disease and bronchial carcinoma, as well in the adjacent normal tissue, was demonstrated for the first time, at least to the best of our knowledge. On the whole, the immunohistochemistry data of the present study suggest that TMPRSS4 may be implicated in the broader (pulmonary and extra‑pulmonary) COVID‑19 symptomatology; thus, it may be responsible for the tropism of this coronavirus both in the GI tract and lungs.
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April-2022
Volume 25 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
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Spandidos Publications style
Kerslake R, Randeva HS, Jonigk D, Werlein C, Robertus JL, Katopodis P, Jasker P, Spandidos DA, Kyrou I, Karteris E, Karteris E, et al: Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs. Mol Med Rep 25: 138, 2022.
APA
Kerslake, R., Randeva, H.S., Jonigk, D., Werlein, C., Robertus, J.L., Katopodis, P. ... Karteris, E. (2022). Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs. Molecular Medicine Reports, 25, 138. https://doi.org/10.3892/mmr.2022.12654
MLA
Kerslake, R., Randeva, H. S., Jonigk, D., Werlein, C., Robertus, J. L., Katopodis, P., Jasker, P., Spandidos, D. A., Kyrou, I., Karteris, E."Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs". Molecular Medicine Reports 25.4 (2022): 138.
Chicago
Kerslake, R., Randeva, H. S., Jonigk, D., Werlein, C., Robertus, J. L., Katopodis, P., Jasker, P., Spandidos, D. A., Kyrou, I., Karteris, E."Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs". Molecular Medicine Reports 25, no. 4 (2022): 138. https://doi.org/10.3892/mmr.2022.12654