Glucocorticoid prevents CD138 expression in T cells of autoimmune MRL/<em>lpr</em> mice

Xie,Tianhong; Liu,Huiqiang; Li,Ping

doi:10.3892/mmr.2022.12727

Glucocorticoid prevents CD138 expression in T cells of autoimmune MRL/lpr mice

Authors:
- Tianhong Xie
- Huiqiang Liu
- Ping Li
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Affiliations: Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing 100010, P.R. China, Department of Pathology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, P.R. China
Published online on: May 4, 2022 https://doi.org/10.3892/mmr.2022.12727
Article Number: 211
Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CD138⁺ T cells, the majority of which are CD4 and CD8 double‑negative (DN) T cells, contribute to the production of anti‑dsDNA antibodies in a CD4 receptor‑dependent way to promote the development of systemic lupus erythematosus (SLE). Accumulation of CD138⁺ T cells in the spleen of MRL/lpr mice was significantly reduced by prednisone. Reduced expression of CD138 in DN T cells induced by prednisone treatment alleviated the accumulation of DN T cells in MRL/lpr mice. The frequency of CD138⁺ cells in CD4⁺ T cells of prednisone‑treated MRL/lpr mice was also significantly reduced, which subsequently contributed to reduced production of anti‑dsDNA antibody in the prednisone‑treated MRL/lpr mice. Additionally, prednisone significantly reduced serum IgG and IgG subsets and simultaneously increased IgM secretion in serum. This suggested that glucocorticoids played a protective role during SLE treatment in MRL/lpr mice by promoting the production of IgM. The present study provides new insights into the mechanism of glucocorticoid for the treatment of SLE.

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