E2F1 promotes Warburg effect and cancer progression via upregulating ENO2 expression in Ewing sarcoma

Jiang,Xianyong; Chen,Zhen; Zhu,Junping; Han,Jun; You,Gaoliang; Li,Yonghong; Liu,Tiancheng; Ye,Heng

doi:10.3892/mmr.2022.12753

E2F1 promotes Warburg effect and cancer progression via upregulating ENO2 expression in Ewing sarcoma

Authors:
- Xianyong Jiang
- Zhen Chen
- Junping Zhu
- Jun Han
- Gaoliang You
- Yonghong Li
- Tiancheng Liu
- Heng Ye
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Affiliations: Department of Orthopedics, Wuhan Hanyang Hospital, Wuhan University of Science and Technology, Wuhan, Hubei 430050, P.R. China, Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China, Medical Examination Center, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China
Published online on: May 27, 2022 https://doi.org/10.3892/mmr.2022.12753
Article Number: 237
Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Altered glucose metabolism is an important characteristic of cancer cells, which is referred to as Warburg effect or aerobic glycolysis. Ewing sarcoma (EWS) is a highly malignant tumor that occurs in children and adolescents. However, the functions of aerobic glycolysis in EWS remain to be elucidated. The present study identified a transcription factor, E2F transcription factor 1 (E2F1), as a new regulator of cancer the aerobic glycolysis and progression in EWS. The present study showed that E2F1 modulated aerobic glycolysis in EWS cells by effecting glucose uptake, lactate production and ATP generation. Altered E2F1 expression increased or decreased cell viability and invasion in EWS. Mechanistically, the results demonstrated that E2F1 may promote the Warburg effect and cancer progression in EWS via upregulating enolase 2 expression. Generally, these findings indicated that E2F1 involvement in the progression of EWS and could serve as a clinical therapeutic target in EWS.

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