Open Access

Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression

  • Authors:
    • Xiaoling Li
    • Runqi Chen
    • Lina Wang
    • Zengxue Lu
    • Yangjie Li
    • Dun Tang
  • View Affiliations

  • Published online on: July 4, 2022     https://doi.org/10.3892/mmr.2022.12786
  • Article Number: 270
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

In recent years, the global incidence and mortality of myocardial infarction (MI) has increased and become one of the important diseases threatening public health. Long non‑coding (lnc)RNAs are a type of ncRNA that serve critical roles in the progression of various types of disease. The present study aimed to investigate the effect and mechanism of lncRNA cardiac autophagy inhibitory factor (CAIF) on cardiac ischemia/reperfusion (I/R) injury. CAIF was downregulated in the myocardium of I/R rats and cardiomyocytes treated with hydrogen peroxide (H2O2). Further experiments demonstrated that CAIF overexpression inhibited I/R‑induced cardiac infarction and apoptosis in vivo. CAIF decreased H2O2‑induced apoptosis and oxidative stress of cardiomyocytes. Mechanistically, CAIF sponged microRNA (miR)‑488‑5p; this interaction was confirmed by rescue experiments. Moreover, miR‑488‑5p targeted apoptosis and caspase activation inhibitor (AVEN) and inhibited its expression. In summary, the present data identified a novel CAIF/miR‑488‑5p/AVEN signaling axis as a key regulator of myocyte apoptosis, which may be a potential therapeutic target for the treatment of MI.
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August-2022
Volume 26 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li X, Chen R, Wang L, Lu Z, Li Y and Tang D: Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression. Mol Med Rep 26: 270, 2022.
APA
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., & Tang, D. (2022). Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression. Molecular Medicine Reports, 26, 270. https://doi.org/10.3892/mmr.2022.12786
MLA
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., Tang, D."Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression". Molecular Medicine Reports 26.2 (2022): 270.
Chicago
Li, X., Chen, R., Wang, L., Lu, Z., Li, Y., Tang, D."Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression". Molecular Medicine Reports 26, no. 2 (2022): 270. https://doi.org/10.3892/mmr.2022.12786