Open Access

Pharmacological activity of capsaicin: Mechanisms and controversies (Review)

  • Authors:
    • Wei Zhang
    • Yu Zhang
    • Jinke Fan
    • Zhiguo Feng
    • Xinqiang Song
  • View Affiliations

  • Published online on: January 15, 2024     https://doi.org/10.3892/mmr.2024.13162
  • Article Number: 38
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Capsaicin, which is abundant in chili peppers, exerts antioxidative, antitumor, antiulcer and analgesic effects and it has demonstrated potential as a treatment for cardiovascular, gastrointestinal, oncological and dermatological conditions. Unique among natural irritants, capsaicin initially excites neurons but then ‘calms’ them into long‑lasting non‑responsiveness. Capsaicin can also promote weight loss, making it potentially useful for treating obesity. Several mechanisms have been proposed to explain the therapeutic effects of capsaicin, including antioxidation, analgesia and promotion of apoptosis. Some of the mechanisms are proposed to be mediated by the capsaicin receptor (transient receptor potential cation channel subfamily V member 1), but some are proposed to be independent of that receptor. The clinical usefulness of capsaicin is limited by its short half‑life. The present review provided an overview of what is known about the therapeutic effects of capsaicin and the mechanisms involved and certain studies arguing against its clinical use were mentioned.
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March-2024
Volume 29 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang W, Zhang Y, Fan J, Feng Z and Song X: Pharmacological activity of capsaicin: Mechanisms and controversies (Review). Mol Med Rep 29: 38, 2024
APA
Zhang, W., Zhang, Y., Fan, J., Feng, Z., & Song, X. (2024). Pharmacological activity of capsaicin: Mechanisms and controversies (Review). Molecular Medicine Reports, 29, 38. https://doi.org/10.3892/mmr.2024.13162
MLA
Zhang, W., Zhang, Y., Fan, J., Feng, Z., Song, X."Pharmacological activity of capsaicin: Mechanisms and controversies (Review)". Molecular Medicine Reports 29.3 (2024): 38.
Chicago
Zhang, W., Zhang, Y., Fan, J., Feng, Z., Song, X."Pharmacological activity of capsaicin: Mechanisms and controversies (Review)". Molecular Medicine Reports 29, no. 3 (2024): 38. https://doi.org/10.3892/mmr.2024.13162