Open Access

Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)

  • Authors:
    • Jiaqin Gao
    • Bin Zuo
    • Yang He
  • View Affiliations

  • Published online on: January 16, 2024     https://doi.org/10.3892/mmr.2024.13164
  • Article Number: 40
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. It is a critical pre‑stage condition of severe hepatopathy, characterized by excessive accumulation of extracellular matrix components and ongoing chronic inflammation. To date, early prevention of liver fibrosis remains challenging. As the most abundant non‑parenchymal hepatic cell population, liver sinusoidal endothelial cells (LSECs) are stabilizers that maintain the intrahepatic environment. Notably, LSECs dysfunction appears to be implicated in the progression of liver fibrosis via numerous mechanisms. Following sustained liver injury, they lose their fenestrae (cytoplasmic pores) and change their crosstalk with other cellular interactions in the hepatic blood environment. LSEC‑targeted therapy has shown promising effects on fibrosis resolution, opening up new opportunities for anti‑fibrotic therapy. In light of this, the present study summarized changes in LSECs during liver fibrosis and their interactions with hepatic milieu, as well as possible therapeutic approaches that specially target LSECs.
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March-2024
Volume 29 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Gao J, Zuo B and He Y: Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review). Mol Med Rep 29: 40, 2024
APA
Gao, J., Zuo, B., & He, Y. (2024). Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review). Molecular Medicine Reports, 29, 40. https://doi.org/10.3892/mmr.2024.13164
MLA
Gao, J., Zuo, B., He, Y."Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)". Molecular Medicine Reports 29.3 (2024): 40.
Chicago
Gao, J., Zuo, B., He, Y."Liver sinusoidal endothelial cells as potential drivers of liver fibrosis (Review)". Molecular Medicine Reports 29, no. 3 (2024): 40. https://doi.org/10.3892/mmr.2024.13164