Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan
- Authors:
- Jai-Sing Yang
- Ting-Yuan Liu
- Hsing-Fang Lu
- Shih-Chang Tsai
- Wen-Ling Liao
- Yu-Jen Chiu
- Yu-Wen Wang
- Fuu-Jen Tsai
-
Affiliations: Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan, R.O.C., Million‑Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung 404327, Taiwan, R.O.C., Department of Biological Science and Technology, China Medical University, Taichung 406040, Taiwan, R.O.C., Graduate Institute of Integrated Medicine, China Medical University, Taichung 404333, Taiwan, R.O.C., Department of Surgery, Division of Plastic and Reconstructive Surgery, Taipei Veterans General Hospital, Taipei 112201, Taiwan, R.O.C., 8School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404333, Taiwan, R.O.C. - Published online on: May 13, 2024 https://doi.org/10.3892/mmr.2024.13239
- Article Number: 115
-
Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Balda A, Wani I, Roohi TF, Suman, Krishna KL, Mehdi S, Nadiga AP, Makkapati M and Baig MAI: Psoriasis and skin cancer-Is there a link? Int Immunopharmacol. 121:1104642023. View Article : Google Scholar : PubMed/NCBI | |
Chi CC, Wu YW, Chao TH, Chen CC, Chen YJ, Cheng HM, Chiu HY, Chiu YW, Chung WH, Hsieh TY, et al: 2022 Taiwanese Dermatological Association (TDA), Taiwanese Association for Psoriasis and Skin Immunology (TAPSI), and Taiwan Society of cardiology (TSOC) joint consensus recommendations for the management of psoriatic disease with attention to cardiovascular comorbidities. J Formos Med Assoc. 122:442–457. 2023. View Article : Google Scholar : PubMed/NCBI | |
Michalek IM, Loring B and John SM: A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol. 31:205–212. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang TS, Hsieh CF and Tsai TF: Epidemiology of psoriatic disease and current treatment patterns from 2003 to 2013: A nationwide, population-based observational study in Taiwan. J Dermatol Sci. 84:340–345. 2016. View Article : Google Scholar : PubMed/NCBI | |
Kubota K, Kamijima Y, Sato T, Ooba N, Koide D, Iizuka H and Nakagawa H: Epidemiology of psoriasis and palmoplantar pustulosis: A nationwide study using the Japanese national claims database. BMJ Open. 5:e0064502015. View Article : Google Scholar : PubMed/NCBI | |
Lee JY, Kang S, Park JS and Jo SJ: Prevalence of psoriasis in Korea: A population-based epidemiological study using the Korean National Health Insurance Database. Ann Dermatol. 29:761–767. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ding X, Wang T, Shen Y, Wang X, Zhou C, Tian S, Liu Y, Peng G, Zhou J, Xue S, et al: Prevalence of psoriasis in China: A population-based study in six cities. Eur J Dermatol. 22:663–667. 2012. View Article : Google Scholar : PubMed/NCBI | |
Yang SF, Lin MH, Chou PC, Hu SK, Shih SY, Yu HS and Yu S: Genetics of generalized pustular psoriasis: Current understanding and implications for future therapeutics. Genes (Basel). 14:12972023. View Article : Google Scholar : PubMed/NCBI | |
Lee LL, Huo AP and Chen SL: Experiences and coping behaviors of patients with psoriasis: A qualitative study. J Dermatolog Treat. 34:21936612023. View Article : Google Scholar : PubMed/NCBI | |
Wang CY, Wang CW, Chen CB, Chen WT, Chang YC, Hui RC and Chung WH: Pharmacogenomics on the treatment response in patients with psoriasis: An updated review. Int J Mol Sci. 24:73292023. View Article : Google Scholar : PubMed/NCBI | |
Honma M and Hayashi K: Psoriasis: Recent progress in molecular-targeted therapies. J Dermatol. 48:761–777. 2021. View Article : Google Scholar : PubMed/NCBI | |
Furue M and Kadono T: Psoriasis: Behind the scenes. J Dermatol. 43:4–8. 2016. View Article : Google Scholar : PubMed/NCBI | |
Rendon A and Schakel K: Psoriasis pathogenesis and treatment. Int J Mol Sci. 20:14752019. View Article : Google Scholar : PubMed/NCBI | |
Ohata C, Anezaki H, Kaneko S, Okazaki F, Ito K, Matsuzaka Y, Kikuchi S, Koike Y, Murota H, Miyagi T, et al: Clinical characteristics of patients with psoriasis with family history: A multicenter observational study. J Dermatol. 50:746–752. 2023. View Article : Google Scholar : PubMed/NCBI | |
Bayaraa B and Imafuku S: Relationship between environmental factors, age of onset and familial history in Japanese patients with psoriasis. J Dermatol. 45:715–718. 2018. View Article : Google Scholar : PubMed/NCBI | |
Kaur I, Handa S and Kumar B: Natural history of psoriasis: A study from the Indian subcontinent. J Dermatol. 24:230–234. 1997. View Article : Google Scholar : PubMed/NCBI | |
Kocaaga A and Kocaaga M: Psoriasis: An Immunogenetic perspective. Glob Med Genet. 9:82–89. 2022. View Article : Google Scholar : PubMed/NCBI | |
Elyoussfi S, Rane SS, Eyre S and Warren RB: TYK2 as a novel therapeutic target in psoriasis. Expert Rev Clin Pharmacol. 16:549–558. 2023. View Article : Google Scholar : PubMed/NCBI | |
Yarmolinsky J, Amos CI, Hung RJ, Moreno V, Burrows K, Smith-Byrne K, Atkins JR, Brennan P; Colon Cancer Family Registry (CCFR), Colorectal Cancer Transdisciplinary Study (CORECT), ; et al: Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk. Int J Cancer. 151:2155–2160. 2022. View Article : Google Scholar : PubMed/NCBI | |
Enerback C, Sandin C, Lambert S, Zawistowski M, Stuart PE, Verma D, Tsoi LC, Nair RP, Johnston A and Elder JT: The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells. Sci Rep. 8:70432018. View Article : Google Scholar : PubMed/NCBI | |
Hao L, Kraft P, Berriz GF, Hynes ED, Koch C, Korategere V Kumar P, Parpattedar SS, Steeves M, Yu W, et al: Development of a clinical polygenic risk score assay and reporting workflow. Nat Med. 28:1006–1013. 2022. View Article : Google Scholar : PubMed/NCBI | |
Liao WL, Huang YN, Chang YW, Liu TY, Lu HF, Tiao ZY, Su PH, Wang CH and Tsai FJ: Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population. Diabetes Obes Metab. 25:2928–2936. 2023. View Article : Google Scholar : PubMed/NCBI | |
Janssens ACJW: Validity of polygenic risk scores: Are we measuring what we think we are? Hum Mol Genet. 28:R143–R150. 2019. View Article : Google Scholar : PubMed/NCBI | |
Cross B, Turner R and Pirmohamed M: Polygenic risk scores: An overview from bench to bedside for personalised medicine. Front Genet. 13:10006672022. View Article : Google Scholar : PubMed/NCBI | |
Dixon P, Keeney E, Taylor JC, Wordsworth S and Martin RM: Can polygenic risk scores contribute to cost-effective cancer screening? A systematic review. Genet Med. 24:1604–1617. 2022. View Article : Google Scholar : PubMed/NCBI | |
Byrne L and Toland AE: Polygenic risk scores in prostate cancer risk assessment and screening. Urol Clin North Am. 48:387–399. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lambert SA, Abraham G and Inouye M: Towards clinical utility of polygenic risk scores. Hum Mol Genet. 28:R133–R142. 2019. View Article : Google Scholar : PubMed/NCBI | |
Johnson D, Wilke MAP, Lyle SM, Kowalec K, Jorgensen A, Wright GEB and Drögemöller BI: A systematic review and analysis of the use of polygenic scores in pharmacogenomics. Clin Pharmacol Ther. 111:919–930. 2022. View Article : Google Scholar : PubMed/NCBI | |
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, et al: A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet. 53:1415–1424. 2021. View Article : Google Scholar : PubMed/NCBI | |
Chen TC, Wang TC, Yiu ZZN, Lee MS, Chen LC, Chan KA, Griffiths CEM and Ashcroft DM; Global Psoriasis Atlas (GPA), : Risk of serious infection and infection mortality in patients with psoriasis: A nationwide cohort study using the Taiwan National Health Insurance claims database. J Eur Acad Dermatol Venereol. 38:136–144. 2024. View Article : Google Scholar : PubMed/NCBI | |
Hsu MC, Wang CC, Huang LY, Lin CY, Lin FJ and Toh S: Effect of ICD-9-CM to ICD-10-CM coding system transition on identification of common conditions: An interrupted time series analysis. Pharmacoepidemiol Drug Saf. 30:1653–1674. 2021. View Article : Google Scholar : PubMed/NCBI | |
Huang YH, Tang CH, Goh CH, Chang CL, Qiu H, Yang YW, Saadoun C, Chang CL and Liu Y: Persistence and adherence to biologics in patients with psoriasis in Taiwan: A new biologics user cohort study. Front Pharmacol. 13:8809852022. View Article : Google Scholar : PubMed/NCBI | |
Wei JC, Shi LH, Huang JY, Wu XF, Wu R and Chiou JY: Epidemiology and medication pattern change of psoriatic diseases in Taiwan from 2000 to 2013: A nationwide, population-based cohort study. J Rheumatol. 45:385–392. 2018. View Article : Google Scholar : PubMed/NCBI | |
Lee WC, Wang LY and Cheng KF: An easy-to-implement approach for analyzing case-control and case-only studies assuming gene-environment independence and Hardy-Weinberg equilibrium. Stat Med. 29:2557–2567. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chiou JS, Cheng CF, Liang WM, Chou CH, Wang CH, Lin WD, Chiu ML, Cheng WC, Lin CW, Lin TH, et al: Your height affects your health: genetic determinants and health-related outcomes in Taiwan. BMC Med. 20:2502022. View Article : Google Scholar : PubMed/NCBI | |
Genomes Project Consortium, . Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Korbel JO, Marchini JL, McCarthy S, McVean GA and Abecasis GR: A global reference for human genetic variation. Nature. 526:68–74. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lu HF, Chou CH, Lin YJ, Uchiyama S, Terao C, Wang YW, Yang JS, Liu TY, Wong HS, Chen SC and Tsai FJ: The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases. Clin Immunol. 260:1098972024. View Article : Google Scholar : PubMed/NCBI | |
Liu TY, Lin CF, Wu HT, Wu YL, Chen YC, Liao CC, Chou YP, Chao D, Chang YS, Lu HF, et al: Comparison of multiple imputation algorithms and verification using whole-genome sequencing in the CMUH genetic biobank. Biomedicine (Taipei). 11:57–65. 2021. View Article : Google Scholar : PubMed/NCBI | |
Yang JS, Liu TY, Chen YC, Tsai SC, Chiu YJ, Liao CC and Tsai FJ: Genome-Wide association study of alopecia areata in Taiwan: The conflict between individuals and hair follicles. Clin Cosmet Investig Dermatol. 16:2597–2612. 2023. View Article : Google Scholar : PubMed/NCBI | |
Wu CY, Hu HY, Li CP, Chou YJ and Chang YT: Comorbidity profiles of psoriasis in Taiwan: A latent class analysis. PLoS One. 13:e01925372018. View Article : Google Scholar : PubMed/NCBI | |
Cheng YD, Lu CC, Hsu YM, Tsai FJ, Bau DT, Tsai SC, Cheng CC, Lin JJ, Huang YY, Juan YN, et al: In Silico and In Vitro studies of Taiwan Chingguan Yihau (NRICM101) on TNF-α/IL-1β-induced human lung cells. Biomedicine (Taipei). 12:56–71. 2022. View Article : Google Scholar : PubMed/NCBI | |
Yang JS, Kang CY, Su CH, Chen CJ, Chiu YJ and Hsu YM: Helicobacter pylori Targets in AGS Human gastric adenocarcinoma: In situ proteomic profiling and systematic analysis. Anticancer Res. 42:531–546. 2022. View Article : Google Scholar : PubMed/NCBI | |
Liao WL, Liu TY, Cheng CF, Chou YP, Wang TY, Chang YW, Chen SY and Tsai FJ: Analysis of HLA variants and graves' disease and its comorbidities using a high resolution imputation system to examine electronic medical health records. Front Endocrinol (Lausanne). 13:8426732022. View Article : Google Scholar : PubMed/NCBI | |
Liu TY, Liao WL, Wang TY, Chan CJ, Chang JG, Chen YC, Lu HF, Yang HH, Chen SY and Tsai FJ: Genome-wide association study of hyperthyroidism based on electronic medical record from Taiwan. Front Med (Lausanne). 9:8306212022. View Article : Google Scholar : PubMed/NCBI | |
Willer CJ, Li Y and Abecasis GR: METAL: Fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 26:2190–2191. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chiu HY, Tsai SC, Tsai FJ, Lo YH, Cheng CC, Liu TY, Jhan SR, Yang JS and Chiu YJ: Liraglutide With Metformin Therapy Ameliorates Hepatic Steatosis and Liver Injury in a Mouse Model of Non-alcoholic Steatohepatitis. In Vivo. 37:1037–1046. 2023. View Article : Google Scholar : PubMed/NCBI | |
Takenaka S, Itoh T and Fujiwara R: Expression pattern of human ATP-binding cassette transporters in skin. Pharmacol Res Perspect. 1:e000052013. View Article : Google Scholar : PubMed/NCBI | |
Amagai R, Takahashi T, Terui H, Fujimura T, Yamasaki K, Aiba S and Asano Y: The antimicrobial peptide cathelicidin exerts immunomodulatory effects via scavenger receptors. Int J Mol Sci. 24:8752023. View Article : Google Scholar : PubMed/NCBI | |
Orsmark C, Skoog T, Jeskanen L, Kere J and Saarialho-Kere U: Expression of allograft inflammatory factor-1 in inflammatory skin disorders. Acta Derm Venereol. 87:223–227. 2007. View Article : Google Scholar : PubMed/NCBI | |
Zhang F, Han L, Wang B, Huang Q, Yawalkar N, Zhang Z and Yan K: Annexin A6 polymorphism is associated with pro-atherogenic lipid profiles and with the downregulation of methotrexate on anti-atherogenic lipid profiles in psoriasis. J Clin Med. 11:70792022. View Article : Google Scholar | |
Slivka PF, Hsieh CL, Lipovsky A, Pratt SD, Locklear J, Namovic MT, McDonald HA, Wetter J, Edelmayer R, Hu M, et al: Small molecule and pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a novel contributor to keratinocyte inflammatory responses. ACS Chem Biol. 14:857–872. 2019. View Article : Google Scholar : PubMed/NCBI | |
Nakagawa H, Akazaki S, Asahina A, Tokunaga K, Matsuki K, Kuwata S, Ishibashi Y and Juji T: Study of HLA class I, class II and complement genes (C2, C4A, C4B and BF) in Japanese psoriatics and analysis of a newly-found high-risk haplotype by pulsed field gel electrophoresis. Arch Dermatol Res. 283:281–284. 1991. View Article : Google Scholar : PubMed/NCBI | |
Abbas Zadeh S, Mlitz V, Lachner J, Golabi B, Mildner M, Pammer J, Tschachler E and Eckhart L: Phylogenetic profiling and gene expression studies implicate a primary role of PSORS1C2 in terminal differentiation of keratinocytes. Exp Dermatol. 26:352–358. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sanchez F, Holm SJ, Mallbris L, O'Brien KP and Stahle M: STG does not associate with psoriasis in the Swedish population. Exp Dermatol. 13:413–418. 2004. View Article : Google Scholar : PubMed/NCBI | |
Acevedo F and Hammar H: Complement C3 proteins in psoriasis. Br J Dermatol. 121:329–335. 1989. View Article : Google Scholar : PubMed/NCBI | |
Fuentelsaz-Romero S, Cuervo A, Estrada-Capetillo L, Celis R, García-Campos R, Ramírez J, Sastre S, Samaniego R, Puig-Kröger A and Cañete JD: GM-CSF expression and macrophage polarization in joints of undifferentiated arthritis patients evolving to rheumatoid arthritis or psoriatic arthritis. Front Immunol. 11:6139752021. View Article : Google Scholar : PubMed/NCBI | |
Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, et al: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet. 78:827–851. 2006. View Article : Google Scholar : PubMed/NCBI | |
Knight J, Spain SL, Capon F, Hayday A, Nestle FO, Clop A; Wellcome Trust Case Control Consortium; Genetic Analysis of Psoriasis Consortium; I-chip for Psoriasis Consortium; Barker JN, ; et al: Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis. Hum Mol Genet. 21:5185–5192. 2012. View Article : Google Scholar : PubMed/NCBI | |
Rajesh D, Nagraj S, Kumar KSP, Kutty AVM and Balakrishna S: Evaluation of HCP5 and Chemokine C Receptor type 5 gene polymorphisms in indian psoriatic patients. Indian J Dermatol. 64:182–186. 2019. View Article : Google Scholar : PubMed/NCBI | |
Li XL, Yu H and Wu GS: Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population. Int J Immunogenet. 41:503–507. 2014. View Article : Google Scholar : PubMed/NCBI | |
Massy E, Pedini P, Pollet E, Martin M, Roudier J, Picard C and Balandraud N: Association study between HLA-A, -B, -C, -DRB1 alleles and Psoriatic arthritis in southern France. Hum Immunol. 83:515–520. 2022. View Article : Google Scholar : PubMed/NCBI | |
Cassia FF, Cardoso JF, Porto LC, Ramos-E-Silva M and Carneiro S: Association of HLA Alleles and HLA haplotypes with psoriasis, psoriatic arthritis and disease severity in a miscegenated population. Psoriasis (Auckl). 11:41–51. 2021.PubMed/NCBI | |
Crivellato E and Zacchi T: The HLA system and psoriasis: A family study. G Ital Dermatol Venereol. 120:247–254. 1985.(In Italian). PubMed/NCBI | |
Pyo CW, Hur SS, Kim YK, Kim TY and Kim TG: Association of TAP and HLA-DM genes with psoriasis in Koreans. J Invest Dermatol. 120:616–622. 2003. View Article : Google Scholar : PubMed/NCBI | |
Zhou X, He Y, Kuang Y, Chen W and Zhu W: HLA-DQA1 and DQB1 alleles are associated with acitretin response in patients with psoriasis. Front Biosci (Landmark Ed). 27:2662022. View Article : Google Scholar : PubMed/NCBI | |
Zhu KJ, Lv YM, Yin XY, Wang ZX, Sun LD, He SM, Cheng H, Hu DY, Zhang Z, Li Y, et al: Psoriasis regression analysis of MHC loci identifies shared genetic variants with vitiligo. PLoS One. 6:e230892011. View Article : Google Scholar : PubMed/NCBI | |
Shawkatova I, Javor J, Parnicka Z, Kozub P, Zilínková M, Frey P, Ferenčík S and Buc M: HLA-C, DRB1 and DQB1 alleles involved in genetic predisposition to psoriasis vulgaris in the Slovak population. Folia Microbiol (Praha). 58:319–324. 2013. View Article : Google Scholar : PubMed/NCBI | |
Patel F, Marusina AI, Duong C, Adamopoulos IE and Maverakis E: NKG2C, HLA-E and their association with psoriasis. Exp Dermatol. 22:797–799. 2013. View Article : Google Scholar : PubMed/NCBI | |
Tamiya G, Shiina T, Oka A, Tomizawa M, Ota M, Katsuyama Y, Yoshitome M, Makino S, Kimura M and Inoko H: New polymorphic microsatellite markers in the human MHC class I region. Tissue Antigens. 54:221–228. 1999. View Article : Google Scholar : PubMed/NCBI | |
Aractingi S, Briand N, Le Danff C, Viguier M, Bachelez H, Michel L, Dubertret L and Carosella ED: HLA-G and NK receptor are expressed in psoriatic skin: A possible pathway for regulating infiltrating T cells? Am J Pathol. 159:71–77. 2001. View Article : Google Scholar : PubMed/NCBI | |
Lamore SD and Wondrak GT: Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis. Biometals. 24:875–890. 2011. View Article : Google Scholar : PubMed/NCBI | |
Vincken NLA, Welsing PMJ, Silva-Cardoso SC, Bekker CPJ, Lopes AP, Olde Nordkamp M, Leijten EFA, Radstake TRDJ and Angiolilli C: Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-ү signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases. Exp Dermatol. 31:962–969. 2022. View Article : Google Scholar : PubMed/NCBI | |
Bojko A, Ostasz R, Bialecka M, Klimowicz A, Malinowski D, Budawski R, Bojko P, Droździk M and Kurzawski M: IL12B, IL23A, IL23R and HLA-C*06 genetic variants in psoriasis susceptibility and response to treatment. Hum Immunol. 79:213–217. 2018. View Article : Google Scholar : PubMed/NCBI | |
Woo J and Lee C: Identification of functional haplotypes in the promoter region of the LST1 gene. Biochem Genet. 52:365–371. 2014. View Article : Google Scholar : PubMed/NCBI | |
Morelli M, Galluzzo M, Scarponi C, Madonna S, Scaglione GL, Girolomoni G, Talamonti M, Bianchi L and Albanesi C: Allelic Variants of HLA-C Upstream Region, PSORS1C3, MICA, TNFA and genes involved in epidermal homeostasis and barrier function influence the clinical response to Anti-IL-12/IL-23 treatment of patients with psoriasis. Vaccines (Basel). 10:19772022. View Article : Google Scholar : PubMed/NCBI | |
Morelli M, Galluzzo M, Madonna S, Scarponi C, Scaglione GL, Galluccio T, Andreani M, Pallotta S, Girolomoni G, Bianchi L, et al: HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58, and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis. Expert Opin Biol Ther. 21:259–270. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lommers E, Depierreux F, Hansen I, Dive D and Maquet P: NMOSD with anti-MOG antibodies following anti-TNFα therapy: A case report. Mult Scler Relat Disord. 26:37–39. 2018. View Article : Google Scholar : PubMed/NCBI | |
Setsirichok D, Tienboon P, Jaroonruang N, Kittichaijaroen S, Wongseree W, Piroonratana T, Usavanarong T, Limwongse C, Aporntewan C, Phadoongsidhi M and Chaiyaratana N: An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies. Springerplus. 2:2302013. View Article : Google Scholar : PubMed/NCBI | |
Wu X, Dong H, Luo L, Zhu Y, Peng G, Reveille JD and Xiong M: A novel statistic for genome-wide interaction analysis. PLoS Genet. 6:e10011312010. View Article : Google Scholar : PubMed/NCBI | |
Frew JW: The contradictory inefficacy of methotrexate in hidradenitis suppurativa: A need to revise pathogenesis or acknowledge disease heterogeneity? J Dermatolog Treat. 31:422–423. 2020. View Article : Google Scholar : PubMed/NCBI | |
Cai M, Huang H, Hu Z, Yuan T, Li W, Liu Y, Zheng L, Zhang Y, Sheng Y and Zhang X: Two variants in the NOTCH4 and HLA-C genes contribute to familial clustering of psoriasis. Int J Genomics. 2020:69073782020. View Article : Google Scholar : PubMed/NCBI | |
Michailidis C, Karpouzis A, Kourmouli N, Tripsianis G, Diplas A and Veletza S: Notch2, notch4 gene polymorphisms in psoriasis vulgaris. Eur J Dermatol. 23:146–153. 2013. View Article : Google Scholar : PubMed/NCBI | |
Gao W, Sweeney C, Walsh C, Rooney P, McCormick J, Veale DJ and Fearon U: Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2. Ann Rheum Dis. 72:1080–1088. 2013. View Article : Google Scholar : PubMed/NCBI | |
Mehta K, Jaiswal P, Briggs F, Faubion WA, Tabibian JH, Cominelli F and Dave M: In-patient outcomes of hematopoietic stem cell transplantation in patients with immune mediated inflammatory diseases: A nationwide study. Sci Rep. 8:68252018. View Article : Google Scholar : PubMed/NCBI | |
Chang YT, Liu HN, Shiao YM, Lin MW, Lee DD, Liu MT, Wang WJ, Wu S, Lai CY and Tsai SF: A study of PSORS1C1 gene polymorphisms in Chinese patients with psoriasis. Br J Dermatol. 153:90–96. 2005. View Article : Google Scholar : PubMed/NCBI | |
Skibola CF, Bracci PM, Halperin E, Conde L, Craig DW, Agana L, Iyadurai K, Becker N, Brooks-Wilson A, Curry JD, et al: Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Nat Genet. 41:873–875. 2009. View Article : Google Scholar : PubMed/NCBI | |
Rahman P, Roslin NM, Pellett FJ, Lemire M, Greenwood CM, Beyene J, Pope A, Peddle L, Paterson AD, Uddin M and Gladman DD: High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis. Ann Rheum Dis. 70:690–694. 2011. View Article : Google Scholar : PubMed/NCBI | |
Gregory AP, Dendrou CA, Attfield KE, Haghikia A, Xifara DK, Butter F, Poschmann G, Kaur G, Lambert L, Leach OA, et al: TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature. 488:508–511. 2012. View Article : Google Scholar : PubMed/NCBI | |
Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, et al: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 41:199–204. 2009. View Article : Google Scholar : PubMed/NCBI | |
Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, Thompson WK, Hernandez DG, Djurovic S, Schork AJ, et al: Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases. JAMA Neurol. 74:780–792. 2017. View Article : Google Scholar : PubMed/NCBI | |
Roy M, Singh K, Shinde A, Singh J, Mane M, Bedekar S, Tailor Y, Gohel D, Vasiyani H, Currim F and Singh R: TNF-α-induced E3 ligase, TRIM15 inhibits TNF-alpha-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1. Cell Signal. 91:1102102022. View Article : Google Scholar : PubMed/NCBI | |
Miao X, Xiang Y, Mao W, Chen Y, Li Q and Fan B: TRIM27 promotes IL-6-induced proliferation and inflammation factor production by activating STAT3 signaling in HaCaT cells. Am J Physiol Cell Physiol. 318:C272–C281. 2020. View Article : Google Scholar : PubMed/NCBI | |
He P, Cao RR, Deng FY and Lei SF: Identification of potential pleiotropic genes for immune and skeletal diseases using multivariate MetaCCA analysis. Curr Genomics. 22:596–606. 2021. View Article : Google Scholar : PubMed/NCBI | |
Burkhart JG, Wu G, Song X, Raimondi F, McWeeney S, Wong MH and Deng Y: Biology-inspired graph neural network encodes reactome and reveals biochemical reactions of disease. Patterns (NY). 4:1007582023. View Article : Google Scholar : PubMed/NCBI | |
Zhen Q, Yang Z, Wang W, Li B, Bai M, Wu J, Ge H, Dong Z, Shen J, Tang H, et al: Genetic study on small insertions and deletions in psoriasis reveals a role in complex human diseases. J Invest Dermatol. 139:2302–2312 e14. 2019. View Article : Google Scholar : PubMed/NCBI | |
Gupta R, Debbaneh MG and Liao W: Genetic epidemiology of psoriasis. Curr Dermatol Rep. 3:61–78. 2014. View Article : Google Scholar : PubMed/NCBI | |
Oh SM, Kim SK, Ahn HJ and Jeong KH: A pilot genome-wide association study identifies novel markers of metabolic syndrome in patients with psoriasis. Ann Dermatol. 35:285–292. 2023. View Article : Google Scholar : PubMed/NCBI | |
Chen W, Wang W, Yong L, Zhen Q, Yu Y, Ge H, Mao Y, Cao L, Zhang R, Hu X, et al: Genome-wide meta-analysis identifies ten new psoriasis susceptibility loci in the Chinese population. J Genet Genomics. 49:177–180. 2022. View Article : Google Scholar : PubMed/NCBI | |
Connell WT, Hong J and Liao W: Genome-Wide association study of ustekinumab response in psoriasis. Front Immunol. 12:8151212022. View Article : Google Scholar : PubMed/NCBI | |
Ren Y, Wang L, Dai H, Qiu G, Liu J, Yu D, Liu J, Lyu CZ, Liu L and Zheng M: Genome-wide association analysis of anti-TNF-α treatment response in Chinese patients with psoriasis. Front Pharmacol. 13:9689352022. View Article : Google Scholar : PubMed/NCBI | |
Kisielnicka A, Sobalska-Kwapis M, Purzycka-Bohdan D, Nedoszytko B, Zabłotna M, Seweryn M, Strapagiel D, Nowicki RJ, Reich A, Samotij D, et al: The analysis of a genome-wide association study (GWAS) of overweight and obesity in psoriasis. Int J Mol Sci. 23:73962022. View Article : Google Scholar : PubMed/NCBI | |
Huang YH, See LC, Chang YC, Chung WH, Chang LC, Yang SF and Su SC: Impact of ABCG2 gene polymorphism on the predisposition to psoriasis. Genes (Basel). 12:16012021. View Article : Google Scholar : PubMed/NCBI | |
Chang YC, Wu WM, Huang YH, Chung WH, Tsai HY and Hsu LA: The (CCTTT) n pentanucleotide repeat polymorphism in the inducible nitric oxide synthase gene promoter and the risk of psoriasis in Taiwanese. Arch Dermatol Res. 307:425–432. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chandran V and Raychaudhuri SP: Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J Autoimmun. 34:J314–J321. 2010. View Article : Google Scholar : PubMed/NCBI | |
Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, Tejasvi T, Voorhees JJ, Abecasis GR and Nair RP: Molecular dissection of psoriasis: Integrating genetics and biology. J Invest Dermatol. 130:1213–1226. 2010. View Article : Google Scholar : PubMed/NCBI | |
Sanchez-Mazas A: A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations. Swiss Med Wkly. 150:W202142020.PubMed/NCBI | |
Buhler S and Sanchez-Mazas A: HLA DNA sequence variation among human populations: Molecular signatures of demographic and selective events. PLoS One. 6:e146432011. View Article : Google Scholar : PubMed/NCBI | |
Melief CJ and Kast WM: Cytotoxic T lymphocyte therapy of cancer and tumor escape mechanisms. Semin Cancer Biol. 2:347–354. 1991.PubMed/NCBI | |
Neefjes J, Jongsma ML, Paul P and Bakke O: Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol. 11:823–836. 2011. View Article : Google Scholar : PubMed/NCBI | |
Rock KL, Reits E and Neefjes J: Present Yourself! By MHC Class I and MHC Class II Molecules. Trends Immunol. 37:724–737. 2016. View Article : Google Scholar : PubMed/NCBI | |
Gottlieb AB: Immunologic mechanisms in psoriasis. J Invest Dermatol. 95 (5 Suppl):18S–19S. 1990. View Article : Google Scholar : PubMed/NCBI | |
Harden JL, Krueger JG and Bowcock AM: The immunogenetics of psoriasis: A comprehensive review. J Autoimmun. 64:66–73. 2015. View Article : Google Scholar : PubMed/NCBI | |
Bartosinska J, Michalak-Stoma A, Kowal M, Raczkiewicz D, Krasowska D, Chodorowska G and Giannopoulos K: Analysis of circulating soluble programmed death 1 (PD-1), neuropilin 1 (NRP-1) and human leukocyte antigen-G (HLA-G) in psoriatic patients. Postepy Dermatol Alergol. 36:167–172. 2019. View Article : Google Scholar : PubMed/NCBI | |
Lee YH, Choi SJ, Ji JD and Song GG: Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet's disease. Mol Biol Rep. 39:5953–5959. 2012. View Article : Google Scholar : PubMed/NCBI | |
Sokolik R, Gebura K, Iwaszko M, Świerkot J, Korman L, Wiland P and Bogunia-Kubik K: Significance of association of HLA-C and HLA-E with psoriatic arthritis. Hum Immunol. 75:1188–1191. 2014. View Article : Google Scholar : PubMed/NCBI | |
Dand N, Duckworth M, Baudry D, Russell A, Curtis CJ, Lee SH, Evans I, Mason KJ, Alsharqi A, Becher G, et al: HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. J Allergy Clin Immunol. 143:2120–2130. 2019. View Article : Google Scholar : PubMed/NCBI | |
Talamonti M, Galluzzo M, Zangrilli A, Papoutsaki M, Egan CG, Bavetta M, Tambone S, Fargnoli MC and Bianchi L: HLA-C*06:02 does not predispose to clinical response following long-term adalimumab treatment in psoriatic patients: A retrospective cohort study. Mol Diagn Ther. 21:295–301. 2017. View Article : Google Scholar : PubMed/NCBI | |
Stuart PE, Tejasvi T, Shaiq PA, Kullavanijaya P, Qamar R, Raja GK, Li Y, Voorhees JJ, Abecasis GR, Elder JT and Nair RP: A single SNP surrogate for genotyping HLA-C*06:02 in diverse populations. J Invest Dermatol. 135:1177–1180. 2015. View Article : Google Scholar : PubMed/NCBI | |
Nikamo P and Stahle M: Cost-effective HLA-Cw06:02 typing in a Caucasian population. Exp Dermatol. 21:221–223. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chiu HY, Huang PY, Jee SH, Hu CY, Chou CT, Chang YT, Hwang CY and Tsai TF: HLA polymorphism among Chinese patients with chronic plaque psoriasis: subgroup analysis. Br J Dermatol. 166:288–297. 2012. View Article : Google Scholar : PubMed/NCBI | |
Shen M, Lim SWD, Tan ES, Oon HH and Ren EC: HLA correlations with clinical phenotypes and risk of metabolic comorbidities in Singapore Chinese psoriasis patients. Mol Diagn Ther. 23:751–760. 2019. View Article : Google Scholar : PubMed/NCBI | |
Cai M, Huang H, Ran D, Zheng X, Wen L, Zhu Z, Liu L, Zhang C, Hong X, Hong J, et al: HLA-C*01:02 and HLA-A*02:07 confer risk specific for psoriatic patients in Southern China. J Invest Dermatol. 139:2045–2048. e42019. View Article : Google Scholar : PubMed/NCBI | |
Hirata J, Hirota T, Ozeki T, Kanai M, Sudo T, Tanaka T, Hizawa N, Nakagawa H, Sato S, Mushiroda T, et al: Variants at HLA-A, HLA-C, and HLA-DQB1 Confer Risk of Psoriasis Vulgaris in Japanese. J Invest Dermatol. 138:542–548. 2018. View Article : Google Scholar : PubMed/NCBI | |
van Vugt LJ, van den Reek JMPA, Hannink G, Coenen MJH and de Jong EMGJ: Association of HLA-C*06:02 Status With Differential Response to Ustekinumab in Patients With Psoriasis: A systematic review and meta-analysis. JAMA Dermatol. 155:708–715. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wei P, Yang Y, Liu Z, Luo Z, Tu W, Han J, Deng Y and Yin L: Characterization of autoantigen presentation by HLA-C*06:02 in psoriasis. J Invest Dermatol. 137:2238–2241. 2017. View Article : Google Scholar : PubMed/NCBI | |
Huang YW and Tsai TF: HLA-Cw1 and psoriasis. Am J Clin Dermatol. 22:339–347. 2021. View Article : Google Scholar : PubMed/NCBI | |
Teng MW, Bowman EP, McElwee JJ, Smyth MJ, Casanova JL, Cooper AM and Cua DJ: IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med. 21:719–729. 2015. View Article : Google Scholar : PubMed/NCBI | |
Mirlekar B and Pylayeva-Gupta Y: IL-12 family cytokines in cancer and immunotherapy. Cancers (Basel). 13:1672021. View Article : Google Scholar : PubMed/NCBI | |
Gee K, Guzzo C, Che Mat NF, Ma W and Kumar A: The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets. 8:40–52. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ek WE, Karlsson T, Hoglund J, Rask-Andersen M and Johansson A: Causal effects of inflammatory protein biomarkers on inflammatory diseases. Sci Adv. 7:eabl43592021. View Article : Google Scholar : PubMed/NCBI | |
Lowes MA, Russell CB, Martin DA, Towne JE and Krueger JG: The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol. 34:174–181. 2013. View Article : Google Scholar : PubMed/NCBI | |
Magyari L, Varszegi D, Sarlos P, Jaromi L, Melegh BI, Duga B, Kisfali P, Kovesdi E, Matyas P, Szabo A, et al: Marked differences of haplotype tagging SNP distribution, linkage, and haplotype profile of IL23 receptor gene in Roma and Hungarian population samples. Cytokine. 65:148–152. 2014. View Article : Google Scholar : PubMed/NCBI | |
Ogbodo E, Michelangeli F and Williams JHH: Exogenous heat shock proteins HSPA1A and HSPB1 regulate TNF-α, IL-1β and IL-10 secretion from monocytic cells. FEBS Open Bio. 13:1922–1940. 2023. View Article : Google Scholar : PubMed/NCBI | |
Generali E, Ceribelli A, Stazi MA and Selmi C: Lessons learned from twins in autoimmune and chronic inflammatory diseases. J Autoimmun. 83:51–61. 2017. View Article : Google Scholar : PubMed/NCBI | |
Valdimarsson H: The genetic basis of psoriasis. Clin Dermatol. 25:563–567. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kere J: Mapping and identifying genes for asthma and psoriasis. Philos Trans R Soc Lond B Biol Sci. 360:1551–1561. 2005. View Article : Google Scholar : PubMed/NCBI | |
Feng BJ, Sun LD, Soltani-Arabshahi R, Bowcock AM, Nair RP, Stuart P, Elder JT, Schrodi SJ, Begovich AB, Abecasis GR, et al: Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet. 5:e10006062009. View Article : Google Scholar : PubMed/NCBI | |
Fan X, Yang S, Huang W, Wang ZM, Sun LD, Liang YH, Gao M, Ren YQ, Zhang KY, Du WH, et al: Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population. PLoS Genet. 4:e10000382008. View Article : Google Scholar : PubMed/NCBI | |
Velastegui E, Vera E, Vanden Berghe W, Munoz MS and Orellana-Manzano A: ‘HLA-C: Evolution, epigenetics, and pathological implications in the major histocompatibility complex’. Front Genet. 14:12060342023. View Article : Google Scholar : PubMed/NCBI | |
Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL and Spies T: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 285:727–729. 1999. View Article : Google Scholar : PubMed/NCBI | |
Kowalczyk AP and Green KJ: Structure, function, and regulation of desmosomes. Prog Mol Biol Transl Sci. 116:95–118. 2013. View Article : Google Scholar : PubMed/NCBI | |
Linh NTT, Giang NH, Lien NTK, Trang BK, Trang DT, Ngoc NT, Nghia VX, My LT, Mao CV, Hoang NH and Xuan NT: Association of PSORS1C3, CARD14 and TLR4 genotypes and haplotypes with psoriasis susceptibility. Genet Mol Biol. 45:e202200992022. View Article : Google Scholar : PubMed/NCBI | |
Allen MH, Ameen H, Veal C, Evans J, Ramrakha-Jones VS, Marsland AM, Burden AD, Griffiths CE, Trembath RC and Barker JN: The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis. J Invest Dermatol. 124:103–106. 2005. View Article : Google Scholar : PubMed/NCBI | |
Tawfik NZ, Abdallah HY, Hassan R, Hosny A, Ghanem DE, Adel A and Atwa MA: PSORS1 locus genotyping profile in psoriasis: A pilot case-control study. Diagnostics (Basel). 12:10352022. View Article : Google Scholar : PubMed/NCBI | |
Clop A, Bertoni A, Spain SL, Simpson MA, Pullabhatla V, Tonda R, Hundhausen C, Di Meglio P, De Jong P, Hayday AC, et al: An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element. PLoS One. 8:e716902013. View Article : Google Scholar : PubMed/NCBI | |
Wisniewski A, Matusiak L, Szczerkowska-Dobosz A, Nowak I and Kusnierczyk P: HLA-C*06:02-independent, gender-related association of PSORS1C3 and PSORS1C1/CDSN single-nucleotide polymorphisms with risk and severity of psoriasis. Mol Genet Genomics. 293:957–966. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ameen M, Allen MH, Fisher SA, Lewis CM, Cuthbert A, Kondeatis E, Vaughan RW, Murakami H, Nakagawa H and Barker JN: Corneodesmosin (CDSN) gene association with psoriasis vulgaris in Caucasian but not in Japanese populations. Clin Exp Dermatol. 30:414–418. 2005. View Article : Google Scholar : PubMed/NCBI | |
Allen M, Ishida-Yamamoto A, McGrath J, Davison S, Iizuka H, Simon M, Guerrin M, Hayday A, Vaughan R, Serre G, et al: Corneodesmosin expression in psoriasis vulgaris differs from normal skin and other inflammatory skin disorders. Lab Invest. 81:969–976. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tazi Ahnini R, Camp NJ, Cork MJ, Mee JB, Keohane SG, Duff GW and di Giovine FS: Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis. Hum Mol Genet. 8:1135–1140. 1999. View Article : Google Scholar : PubMed/NCBI | |
Zwirner NW, Dole K and Stastny P: Differential surface expression of MICA by endothelial cells, fibroblasts, keratinocytes, and monocytes. Hum Immunol. 60:323–330. 1999. View Article : Google Scholar : PubMed/NCBI | |
Carlen L, Sakuraba K, Stahle M and Sanchez F: HLA-C expression pattern is spatially different between psoriasis and eczema skin lesions. J Invest Dermatol. 127:342–348. 2007. View Article : Google Scholar : PubMed/NCBI | |
Schon MP, Boehncke WH and Brocker EB: Psoriasis: Clinical manifestations, pathogenesis and therapeutic perspectives. Discov Med. 5:253–258. 2005.PubMed/NCBI | |
Telem DF, Israeli S, Sarig O and Sprecher E: Inflammatory peeling skin syndrome caused a novel mutation in CDSN. Arch Dermatol Res. 304:251–255. 2012. View Article : Google Scholar : PubMed/NCBI | |
Maekawa K, Nishikawa J, Kaniwa N, Sugiyama E, Koizumi T, Kurose K, Tohkin M and Saito Y: Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: A partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese. Drug Metab Pharmacokinet. 27:447–450. 2012. View Article : Google Scholar : PubMed/NCBI | |
Lu HF, Liu TY, Chou YP, Chang SS, Hsieh YW, Chang JG and Tsai FJ: Comprehensive characterization of pharmacogenes in a Taiwanese Han population. Front Genet. 13:9486162022. View Article : Google Scholar : PubMed/NCBI | |
Patrick MT, Stuart PE, Zhang H, Zhao Q, Yin X, He K, Zhou XJ, Mehta NN, Voorhees JJ, Boehnke M, et al: Causal relationship and shared genetic loci between psoriasis and type 2 diabetes through trans-disease meta-analysis. J Invest Dermatol. 141:1493–1502. 2021. View Article : Google Scholar : PubMed/NCBI | |
Abramczyk R, Queller JN, Rachfal AW and Schwartz SS: Diabetes and psoriasis: Different sides of the same prism. Diabetes Metab Syndr Obes. 13:3571–3577. 2020. View Article : Google Scholar : PubMed/NCBI | |
Eiris N, Gonzalez-Lara L, Santos-Juanes J, Queiro R, Coto E and Coto-Segura P: Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus. J Dermatol Sci. 75:167–172. 2014. View Article : Google Scholar : PubMed/NCBI | |
Patrick MT, Nair RP, He K, Stuart PE, Billi AC, Zhou X, Gudjonsson JE, Oksenberg JR, Elder JT and Tsoi LC: Shared genetic risk factors for multiple sclerosis/psoriasis suggest involvement of interleukin-17 and janus kinase-signal transducers and activators of transcription signaling. Ann Neurol. 94:384–397. 2023. View Article : Google Scholar : PubMed/NCBI | |
Tang Y, Liu W, Kong W, Zhang S and Zhu T: Multisite chronic pain and the risk of autoimmune diseases: A Mendelian randomization study. Front Immunol. 14:10770882023. View Article : Google Scholar : PubMed/NCBI | |
Huang J, Su B, Karhunen V, Gill D, Zuber V, Ahola-Olli A, Palaniswamy S, Auvinen J, Herzig KH, Keinänen-Kiukaanniemi S, et al: Inflammatory diseases, inflammatory biomarkers, and Alzheimer disease: An observational analysis and mendelian randomization. Neurology. 100:e568–e581. 2023. View Article : Google Scholar : PubMed/NCBI | |
Li C, Li X, Lin J, Cui Y and Shang H: Psoriasis and progression of Parkinson's disease: a Mendelian randomization study. J Eur Acad Dermatol Venereol. 36:2401–2405. 2022. View Article : Google Scholar : PubMed/NCBI | |
Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hübenthal M, et al: Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat Genet. 48:510–518. 2016. View Article : Google Scholar : PubMed/NCBI | |
Yin X, Low HQ, Wang L, Li Y, Ellinghaus E, Han J, Estivill X, Sun L, Zuo X, Shen C, et al: Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun. 6:69162015. View Article : Google Scholar : PubMed/NCBI | |
Gandhi G, Buttar BS, Albert L, Hasan Q and Aggarwal RK: Psoriasis-associated genetic polymorphism in North Indian population in the CCHCR1 gene and in a genomic segment flanking the HLA-C region. Dis Markers. 31:361–370. 2011. View Article : Google Scholar : PubMed/NCBI | |
Chang YT, Hsu CY, Chou CT, Lin MW, Shiao YM, Tsai CY, Yu CW, Shiue JJ, Lee YF, Huang CH, et al: The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese. J Dermatol Sci. 46:153–156. 2007. View Article : Google Scholar : PubMed/NCBI | |
Chang YT, Tsai SF, Lee DD, Shiao YM, Huang CY, Liu HN, Wang WJ and Wong CK: A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. Br J Dermatol. 148:418–423. 2003. View Article : Google Scholar : PubMed/NCBI | |
Xia X, Yu H, Li Y, Liang Y, Li G and Huang F: transcriptome analysis identifies biomarkers for the diagnosis and management of psoriasis complicated with depression. Clin Cosmet Investig Dermatol. 16:1287–1301. 2023. View Article : Google Scholar : PubMed/NCBI | |
Chantarangsu S, Mushiroda T, Mahasirimongkol S, Kiertiburanakul S, Sungkanuparph S, Manosuthi W, Tantisiriwat W, Charoenyingwattana A, Sura T, Takahashi A, et al: Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. Clin Infect Dis. 53:341–348. 2011. View Article : Google Scholar : PubMed/NCBI | |
Sanchez FO, Linga Reddy MV, Mallbris L, Sakuraba K, Stahle M and Alarcon-Riquelme ME: IFN-regulatory factor 5 gene variants interact with the class I MHC locus in the Swedish psoriasis population. J Invest Dermatol. 128:1704–1709. 2008. View Article : Google Scholar : PubMed/NCBI | |
Tervaniemi MH, Siitonen HA, Soderhall C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J and Elomaa O: Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization. PLoS One. 7:e499202012. View Article : Google Scholar : PubMed/NCBI | |
Ishida-Yamamoto A, Furio L, Igawa S, Honma M, Tron E, Malan V, Murakami M and Hovnanian A: Inflammatory peeling skin syndrome caused by homozygous genomic deletion in the PSORS1 region encompassing the CDSN gene. Exp Dermatol. 23:60–63. 2014. View Article : Google Scholar : PubMed/NCBI |