Advances in research on the relationship between the LMNA gene and human diseases (Review)
- Authors:
- Jiumei Zhao
- Huijuan Zhang
- Chenglong Pan
- Qian He
- Kepu Zheng
- Yu Tang
-
Affiliations: Department of Laboratory, Chongqing Nanchuan District People's Hospital, Chongqing Medical University, Chongqing 408400, P.R. China, Forensic Science Centre, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, School of Biomedical Engineering, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, Department of Pathology, The Third Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, Yunnan 650500, P.R. China - Published online on: October 14, 2024 https://doi.org/10.3892/mmr.2024.13358
- Article Number: 236
-
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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|
Donnaloja F, Carnevali F, Jacchetti E and Raimondi MT: Lamin A/C mechanotransduction in laminopathies. Cells. 9:13062020. View Article : Google Scholar | |
|
Burke B and Stewart CL: The nuclear lamins: Flexibility in function. Nat Rev Mol Cell Biol. 14:13–24. 2013. View Article : Google Scholar | |
|
Xie W and Burke B: Lamins. Curr Biol. 26:R348–R350. 2016. View Article : Google Scholar | |
|
Dittmer TA and Misteli T: The lamin protein family. Genome Biol. 12:2222011. View Article : Google Scholar | |
|
Naetar N, Ferraioli S and Foisner R: Lamins in the nuclear interior-life outside the lamina. J Cell Sci. 130:2087–2096. 2017. View Article : Google Scholar | |
|
Tajik A, Zhang Y, Wei F, Sun J, Jia Q, Zhou W, Singh R, Khanna N, Belmont AS and Wang N: Transcription upregulation via force-induced direct stretching of chromatin. Nat Mater. 15:1287–1296. 2016. View Article : Google Scholar | |
|
Ramdas NM and Shivashankar GV: Cytoskeletal control of nuclear morphology and chromatin organization. J Mol Biol. 427:695–706. 2015. View Article : Google Scholar | |
|
Davidson PM and Lammerding J: Broken nuclei-lamins, nuclear mechanics, and disease. Trends Cell Biol. 24:247–256. 2014. View Article : Google Scholar | |
|
Lee JSH, Hale CM, Panorchan P, Khatau SB, George JP, Tseng Y, Stewart CL, Hodzic D and Wirtz D: Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J. 93:2542–2552. 2007. View Article : Google Scholar | |
|
Dahl KN, Kahn SM, Wilson KL and Discher DE: The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. J Cell Sci. 117:4779–4786. 2004. View Article : Google Scholar | |
|
Wang X, Zabell A, Koh W and Tang WH: Lamin A/C cardiomyopathies: Current understanding and novel treatment strategies. Curr Treat Options Cardiovasc Med. 19:212017. View Article : Google Scholar | |
|
Chen SN, Sbaizero O, Taylor MRG and Mestroni L: Lamin A/C cardiomyopathy: Implications for treatment. Curr Cardiol Rep. 21:1602019. View Article : Google Scholar | |
|
Dubik N and Mai S: Lamin A/C: Function in normal and tumor cells. Cancers (Basel). 12:36882020. View Article : Google Scholar | |
|
Lund E, Oldenburg AR, Delbarre E, Freberg CT, Duband-Goulet I, Eskeland R, Buendia B and Collas P: Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Res. 23:1580–1589. 2013. View Article : Google Scholar | |
|
Nmezi B, Xu J, Fu R, Armiger TJ, Rodriguez-Bey G, Powell JS, Ma H, Sullivan M, Tu Y, Chen NY, et al: Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina. Proc Natl Acad Sci USA. 116:4307–4315. 2019. View Article : Google Scholar | |
|
Kang SM, Yoon MH and Park BJ: Laminopathies; mutations on single gene and various human genetic diseases. BMB Rep. 51:327–337. 2018. View Article : Google Scholar | |
|
Sakthivel KM and Sehgal P: A novel role of lamins from genetic disease to cancer biomarkers. Oncol Rev. 10:3092016. | |
|
Foster CR, Przyborski SA, Wilson RG and Hutchison CJ: Lamins as cancer biomarkers. Biochem Soc Trans. 38:297–300. 2010. View Article : Google Scholar | |
|
Wang AS, Kozlov SV, Stewart CL and Horn HF: Tissue specific loss of A-type lamins in the gastrointestinal epithelium can enhance polyp size. Differentiation. 89:11–21. 2015. View Article : Google Scholar | |
|
Fisher DZ, Chaudhary N and Blobel G: cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc Natl Acad Sci USA. 83:6450–6454. 1986. View Article : Google Scholar | |
|
Ishikawa H, Bischoff R and Holtzer H: Mitosis and intermediate-sized filaments in developing skeletal muscle. J Cell Biol. 38:538–555. 1968. View Article : Google Scholar | |
|
Lin F and Worman HJ: Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J Biol Chem. 268:16321–16326. 1993. View Article : Google Scholar | |
|
Zwerger M and Medalia O: From lamins to lamina: A structural perspective. Histochem Cell Biol. 140:3–12. 2013. View Article : Google Scholar | |
|
de Leeuw R, Gruenbaum Y and Medalia O: Nuclear lamins: Thin filaments with major functions. Trends Cell Biol. 28:34–45. 2018. View Article : Google Scholar | |
|
Gruenbaum Y and Medalia O: Lamins: The structure and protein complexes. Curr Opin Cell Biol. 32:7–12. 2015. View Article : Google Scholar | |
|
Turgay Y, Eibauer M, Goldman AE, Shimi T, Khayat M, Ben-Harush K, Dubrovsky-Gaupp A, Sapra KT, Goldman RD and Medalia O: The molecular architecture of lamins in somatic cells. Nature. 543:261–264. 2017. View Article : Google Scholar | |
|
Zwerger M, Roschitzki-Voser H, Zbinden R, Denais C, Herrmann H, Lammerding J, Grütter MG and Medalia O: Altering lamina assembly reveals lamina-dependent and -independent functions for A-type lamins. J Cell Sci. 128:3607–3620. 2015. | |
|
Broers JLV, Peeters EAG, Kuijpers HJH, Endert J, Bouten CVC, Oomens CWJ, Baaijens FPT and Ramaekers FCS: Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: Implications for the development of laminopathies. Hum Mol Genet. 13:2567–2580. 2004. View Article : Google Scholar | |
|
Chiarini F, Evangelisti C, Cenni V, Fazio A, Paganelli F, Martelli AM and Lattanzi G: The cutting edge: The role of mTOR signaling in laminopathies. Int J Mol Sci. 20:8472019. View Article : Google Scholar | |
|
Stick R: The gene structure of Xenopus nuclear lamin A: A model for the evolution of A-type from B-type lamins by exon shuffling. Chromosoma. 101:566–574. 1992. View Article : Google Scholar | |
|
Hanif M, Rosengardten Y, Sagelius H, Rozell B and Eriksson M: Differential expression of A-type and B-type lamins during hair cycling. PLoS One. 4:e41142009. View Article : Google Scholar | |
|
Kim Y, Sharov AA, McDole K, Cheng M, Hao H, Fan CM, Gaiano N, Ko MS and Zheng Y: Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 334:1706–1710. 2011. View Article : Google Scholar | |
|
Al-Saaidi R and Bross P: Do lamin A and lamin C have unique roles? Chromosoma. 124:1–12. 2015. View Article : Google Scholar | |
|
Gruenbaum Y and Foisner R: Lamins: Nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation. Annu Rev Biochem. 84:131–164. 2015. View Article : Google Scholar | |
|
Peter M, Nakagawa J, Dorée M, Labbé JC and Nigg EA: In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell. 61:591–602. 1990. View Article : Google Scholar | |
|
Collas P, Thompson L, Fields AP, Poccia DL and Courvalin JC: Protein kinase C-mediated interphase lamin B phosphorylation and solubilization. J Biol Chem. 272:21274–21280. 1997. View Article : Google Scholar | |
|
Molloy S and Little M: p34cdc2 kinase-mediated release of lamins from nuclear ghosts is inhibited by cAMP-dependent protein kinase. Exp Cell Res. 201:494–499. 1992. View Article : Google Scholar | |
|
Zhang YQ and Sarge KD: Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J Cell Biol. 182:35–39. 2008. View Article : Google Scholar | |
|
Shimi T, Kittisopikul M, Tran J, Goldman AE, Adam SA, Zheng Y, Jaqaman K and Goldman RD: Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy. Mol Biol Cell. 26:4075–4086. 2015. View Article : Google Scholar | |
|
Grossman E, Dahan I, Stick R, Goldberg MW, Gruenbaum Y and Medalia O: Filaments assembly of ectopically expressed Caenorhabditis elegans lamin within Xenopus oocytes. J Struct Biol. 177:113–118. 2012. View Article : Google Scholar | |
|
Kapinos LE, Schumacher J, Mücke N, Machaidze G, Burkhard P, Aebi U, Strelkov SV and Herrmann H: Characterization of the head-to-tail overlap complexes formed by human lamin A, B1 and B2 ‘half-minilamin’ dimers. J Mol Biol. 396:719–731. 2010. View Article : Google Scholar | |
|
Goldberg MW, Huttenlauch I, Hutchison CJ and Stick R: Filaments made from A- and B-type lamins differ in structure and organization. J Cell Sci. 121:215–225. 2008. View Article : Google Scholar | |
|
Schirmer EC and Gerace L: The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths. J Biol Chem. 279:42811–42817. 2004. View Article : Google Scholar | |
|
Schirmer EC, Guan T and Gerace L: Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization. J Cell Biol. 153:479–489. 2001. View Article : Google Scholar | |
|
Moir RD, Yoon M, Khuon S and Goldman RD: Nuclear lamins A and B1: Different pathways of assembly during nuclear envelope formation in living cells. J Cell Biol. 151:1155–1168. 2000. View Article : Google Scholar | |
|
Fawcett DW: On the occurrence of a fibrous lamina on the inner aspect of the nuclear envelope in certain cells of vertebrates. Am J Anat. 119:129–145. 1966. View Article : Google Scholar | |
|
Belmont AS, Zhai Y and Thilenius A: Lamin B distribution and association with peripheral chromatin revealed by optical sectioning and electron microscopy tomography. J Cell Biol. 123:1671–1685. 1993. View Article : Google Scholar | |
|
Taniura H, Glass C and Gerace L: A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones. J Cell Biol. 131:33–44. 1995. View Article : Google Scholar | |
|
Bruston F, Delbarre E, Ostlund C, Worman HJ, Buendia B and Duband-Goulet I: Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin. FEBS Lett. 584:2999–3004. 2010. View Article : Google Scholar | |
|
Guelen L, Pagie L, Brasset E, Meuleman W, Faza MB, Talhout W, Eussen BH, de Klein A, Wessels L, de Laat W and van Steensel B: Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature. 453:948–951. 2008. View Article : Google Scholar | |
|
Stewart CL, Kozlov S, Fong LG and Young SG: Mouse models of the laminopathies. Exp Cell Res. 313:2144–2156. 2007. View Article : Google Scholar | |
|
Tesson F, Saj M, Uvaize MM, Nicolas H, Płoski R and Bilińska Z: Lamin A/C mutations in dilated cardiomyopathy. Cardiol J. 21:331–342. 2014. View Article : Google Scholar | |
|
Fatkin D, MacRae C, Sasaki T, Wolff MR, Porcu M, Frenneaux M, Atherton J, Vidaillet HJ Jr, Spudich S, De Girolami U, et al: Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. N Engl J Med. 341:1715–1724. 1999. View Article : Google Scholar | |
|
van Tintelen JP, Tio RA, Kerstjens-Frederikse WS, van Berlo JH, Boven LG, Suurmeijer AJ, White SJ, den Dunnen JT, te Meerman GJ, Vos YJ, et al: Severe myocardial fibrosis caused by a deletion of the 5′ end of the lamin A/C gene. J Am Coll Cardiol. 49:2430–2439. 2007. View Article : Google Scholar | |
|
Tiwari V, Alam MJ, Bhatia M, Navya M and Banerjee SK: The structure and function of lamin A/C: Special focus on cardiomyopathy and therapeutic interventions. Life Sci. 341:1224892024. View Article : Google Scholar | |
|
Kim Y, Bayona PW, Kim M, Chang J, Hong S, Park Y, Budiman A, Kim YJ, Choi CY, Kim WS, et al: Macrophage Lamin A/C regulates inflammation and the development of obesity-induced insulin resistance. Front Immunol. 9:6962018. View Article : Google Scholar | |
|
Vigouroux C, Guénantin AC, Vatier C, Capel E, Le Dour C, Afonso P, Bidault G, Béréziat V, Lascols O, Capeau J, et al: Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives. Nucleus. 9:235–248. 2018. View Article : Google Scholar | |
|
Cao H and Hegele RA: Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Hum Mol Genet. 9:109–112. 2000. View Article : Google Scholar | |
|
De Sandre-Giovannoli A, Bernard R, Cau P, Navarro C, Amiel J, Boccaccio I, Lyonnet S, Stewart CL, Munnich A, Le Merrer M and Lévy N: Lamin a truncation in Hutchinson-Gilford progeria. Science. 300:20552003. View Article : Google Scholar | |
|
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, et al: Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 423:293–298. 2003. View Article : Google Scholar | |
|
Wong X, Melendez-Perez AJ and Reddy KL: The nuclear lamina. Cold Spring Harb Perspect Biol. 14:a0401132022. View Article : Google Scholar | |
|
Dechat T, Shimi T, Adam SA, Rusinol AE, Andres DA, Spielmann HP, Sinensky MS and Goldman RD: Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. Proc Natl Acad Sci USA. 104:4955–4960. 2007. View Article : Google Scholar | |
|
Ragnauth CD, Warren DT, Liu Y, McNair R, Tajsic T, Figg N, Shroff R, Skepper J and Shanahan CM: Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging. Circulation. 121:2200–2210. 2010. View Article : Google Scholar | |
|
Kirkland NJ, Skalak SH, Whitehead AJ, Hocker JD, Beri P, Vogler G, Hum B, Wang M, Lakatta EG, Ren B, et al: Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs. Nat Aging. 3:17–33. 2023. View Article : Google Scholar | |
|
Maynard S, Hall A, Galanos P, Rizza S, Yamamoto T, Gram HH, Munk SHN, Shoaib M, Sørensen CS, Bohr VA, et al: Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway. Nucleic Acids Res. 50:9948–9965. 2022. View Article : Google Scholar | |
|
Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, et al: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. EMBO J. 41:e1103932022. View Article : Google Scholar | |
|
Yoon MH, Kang SM, Lee SJ, Woo TG, Oh AY, Park S, Ha NC and Park BJ: p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation. Cell Death Dis. 10:1072019. View Article : Google Scholar | |
|
Lochs SJA, Kefalopoulou S and Kind J: Lamina associated domains and gene regulation in development and cancer. Cells. 8:2712019. View Article : Google Scholar | |
|
Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar | |
|
Broers JLV and Ramaekers FCS: The role of the nuclear lamina in cancer and apoptosis. Adv Exp Med Biol. 773:27–48. 2014. View Article : Google Scholar | |
|
Broers JL, Machiels BM, Kuijpers HJ, Smedts F, van den Kieboom R, Raymond Y and Ramaekers FC: A- and B-type lamins are differentially expressed in normal human tissues. Histochem Cell Biol. 107:505–517. 1997. View Article : Google Scholar | |
|
Kaufmann SH, Mabry M, Jasti R and Shaper JH: Differential expression of nuclear envelope lamins A and C in human lung cancer cell lines. Cancer Res. 51:581–566. 1991. | |
|
Guinde J, Frankel D, Perrin S, Delecourt V, Lévy N, Barlesi F, Astoul P, Roll P and Kaspi E: Lamins in lung cancer: Biomarkers and Key factors for disease progression through miR-9 regulation? Cells. 7:782018. View Article : Google Scholar | |
|
Machiels BM, Broers JL, Raymond Y, de Ley L, Kuijpers HJ, Caberg NE and Ramaekers FC: Abnormal A-type lamin organization in a human lung carcinoma cell line. Eur J Cell Biol. 67:328–335. 1995. | |
|
Capo-chichi CD, Cai KQ, Smedberg J, Ganjei-Azar P, Godwin AK and Xu XX: Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer. Chin J Cancer. 30:415–425. 2011. View Article : Google Scholar | |
|
Harris H: Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. Preface. J Cell Sci. 121 (Suppl 1):S5–S6. 2008. | |
|
Holland AJ and Cleveland DW: Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol. 10:478–487. 2009. View Article : Google Scholar | |
|
Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, Lababidi S, Scudiero DA, Weinstein JN and Kirsch IR: Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res. 63:8634–8647. 2003. | |
|
Thompson SL, Bakhoum SF and Compton DA: Mechanisms of chromosomal instability. Curr Biol. 20:R285–R295. 2010. View Article : Google Scholar | |
|
Sen S: Aneuploidy and cancer. Curr Opin Oncol. 12:82–88. 2000. View Article : Google Scholar | |
|
Ozols RF, Bookman MA, Connolly DC, Daly MB, Godwin AK, Schilder RJ, Xu X and Hamilton TC: Focus on epithelial ovarian cancer. Cancer Cell. 5:19–24. 2004. View Article : Google Scholar | |
|
Agarwal R and Kaye SB: Ovarian cancer: Strategies for overcoming resistance to chemotherapy. Nat Rev Cancer. 3:502–516. 2003. View Article : Google Scholar | |
|
Capo-Chichi CD, Cai KQ and Xu XX: Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers. Biomarker Res. 6:302018. View Article : Google Scholar | |
|
Agrelo R, Setien F, Espada J, Artiga MJ, Rodriguez M, Pérez-Rosado A, Sanchez-Aguilera A, Fraga MF, Piris MA and Esteller M: Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma. J Clin Oncol. 23:3940–3947. 2005. View Article : Google Scholar | |
|
Maresca G, Natoli M, Nardella M, Arisi I, Trisciuoglio D, Desideri M, Brandi R, D'Aguanno S, Nicotra MR, D'Onofrio M, et al: LMNA knock-down affects differentiation and progression of human neuroblastoma cells. PLoS One. 7:e455132012. View Article : Google Scholar | |
|
Venables RS, McLean S, Luny D, Moteleb E, Morley S, Quinlan RA, Lane EB and Hutchison CJ: Expression of individual lamins in basal cell carcinomas of the skin. Br J Cancer. 84:512–519. 2001. View Article : Google Scholar | |
|
Foster CR, Robson JL, Simon WJ, Twigg J, Cruikshank D, Wilson RG and Hutchison CJ: The role of Lamin A in cytoskeleton organization in colorectal cancer cells: A proteomic investigation. Nucleus. 2:434–243. 2011. View Article : Google Scholar | |
|
Kong L, Schäfer G, Bu H, Zhang Y, Zhang Y and Klocker H: Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. Carcinogenesis. 33:751–759. 2012. View Article : Google Scholar | |
|
Bell ES, Shah P, Zuela-Sopilniak N, Kim D, Varlet AA, Morival JLP, McGregor AL, Isermann P, Davidson PM, Elacqua JJ, et al: Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer. Oncogene. 41:4211–4230. 2022. View Article : Google Scholar | |
|
Wang Y, Jiang J, He L, Gong G and Wu X: Effect of lamin-A expression on migration and nuclear stability of ovarian cancer cells. Gynecol Oncol. 152:166–176. 2019. View Article : Google Scholar | |
|
Miles FL, Pruitt FL, van Golen KL and Cooper CR: Stepping out of the flow: Capillary extravasation in cancer metastasis. Clin Exp Metastasis. 25:305–324. 2008. View Article : Google Scholar | |
|
Valastyan S and Weinberg RA: Tumor metastasis: Molecular insights and evolving paradigms. Cell. 147:275–292. 2011. View Article : Google Scholar | |
|
Roncato F, Regev O, Feigelson SW, Yadav SK, Kaczmarczyk L, Levi N, Drago-Garcia D, Ovadia S, Kizner M, Addadi Y, et al: Reduced Lamin A/C does not facilitate cancer cell transendothelial migration but compromises lung metastasis. Cancers (Basel). 13:23832021. View Article : Google Scholar | |
|
Mitchell MJ, Denais C, Chan MF, Wang Z, Lammerding J and King MR: Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress. Am J Physiol Cell Physiol. 309:C736–C746. 2015. View Article : Google Scholar | |
|
Ferrari R, Infante E and Chavrier P: Nucleus-invadopodia duo during cancer invasion. Trends Cell Biol. 29:93–96. 2019. View Article : Google Scholar | |
|
Osmanagic-Myers S, Dechat T and Foisner R: Lamins at the crossroads of mechanosignaling. Genes Dev. 29:225–237. 2015. View Article : Google Scholar | |
|
Kaspi E, Frankel D, Guinde J, Perrin S, Laroumagne S, Robaglia-Schlupp A, Ostacolo K, Harhouri K, Tazi-Mezalek R, Micallef J, et al: Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor performance status. PLoS One. 12:e01831362017. View Article : Google Scholar | |
|
Willis ND, Cox TR, Rahman-Casañs SF, Smits K, Przyborski SA, van den Brandt P, van Engeland M, Weijenberg M, Wilson RG, de Bruïne A and Hutchison CJ: Lamin A/C is a risk biomarker in colorectal cancer. PLoS One. 3:e29882008. View Article : Google Scholar | |
|
Setti Boubaker N, Gurtner A, Trabelsi N, Manni I, Ayed H, Saadi A, Zaghbib S, Naimi Z, Sahraoui G, Zouari S, et al: The diagnostic applicability of A-type Lamin in non-muscle invasive bladder cancer. Ann Diagn Pathol. 54:1518082021. View Article : Google Scholar | |
|
Wazir U, Ahmed MH, Bridger JM, Harvey A, Jiang WG, Sharma AK and Mokbel K: The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer. Cell Mol Biol Lett. 18:595–611. 2013. View Article : Google Scholar | |
|
Alhudiri IM, Nolan CC, Ellis IO, Elzagheid A, Rakha EA, Green AR and Chapman CJ: Expression of Lamin A/C in early-stage breast cancer and its prognostic value. Breast Cancer Res Treat. 174:661–668. 2019. View Article : Google Scholar | |
|
Smith ER, George SH, Kobetz E and Xu XX: New biological research and understanding of Papanicolaou's test. Diagn Cytopathol. 46:507–515. 2018. View Article : Google Scholar | |
|
Dekker E, Tanis PJ, Vleugels JLA, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar | |
|
Thompson SL and Compton DA: Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J Cell Biol. 188:369–381. 2010. View Article : Google Scholar | |
|
Saarinen I, Mirtti T, Seikkula H, Boström PJ and Taimen P: Differential predictive roles of A- and B-type nuclear lamins in prostate cancer progression. PLoS One. 10:e01406712015. View Article : Google Scholar | |
|
Meaburn KJ and Misteli T: Assessment of the utility of gene positioning biomarkers in the stratification of prostate cancers. Front Genet. 10:10292019. View Article : Google Scholar | |
|
Grozescu T and Popa F: Prostate cancer between prognosis and adequate/proper therapy. J Med Life. 10:5–12. 2017. | |
|
Setijono SR, Park M, Kim G, Kim Y, Cho KW and Song SJ: miR-218 and miR-129 regulate breast cancer progression by targeting Lamins. Biochem Biophys Res Commun. 496:826–833. 2018. View Article : Google Scholar | |
|
Chiarini F, Paganelli F, Balestra T, Capanni C, Fazio A, Manara MC, Landuzzi L, Petrini S, Evangelisti C, Lollini PL, et al: Lamin A and the LINC complex act as potential tumor suppressors in Ewing Sarcoma. Cell Death Dis. 13:3462022. View Article : Google Scholar | |
|
Snigireva AV, Vrublevskaya VV, Skarga YY, Evdokimovskaya YV and Morenkov OS: Effect of heat shock protein 90 (Hsp90) on migration and invasion of human cancer cells in vitro. Bull Exp Biol Med. 157:476–478. 2014. View Article : Google Scholar | |
|
Meng X, Cao J, Zheng H, Ma X, Wang Y, Tong Y, Xie S, Lu R and Guo L: TPX2 promotes ovarian tumorigenesis by interacting with Lamin A/C and affecting its stability. Cancer Med. 12:9738–9748. 2023. View Article : Google Scholar | |
|
Sidera K and Patsavoudi E: HSP90 inhibitors: Current development and potential in cancer therapy. Recent Pat Anticancer Drug Discov. 9:1–20. 2014. View Article : Google Scholar | |
|
Wang Y, Chen Q, Wu D, Chen Q, Gong G, He L and Wu X: Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells. Cell Death Dis. 12:7862021. View Article : Google Scholar | |
|
Shao X, Tarnasky HA, Lee JP, Oko R and van der Hoorn FA: Spag4, a novel sperm protein, binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme. Dev Biol. 211:109–123. 1999. View Article : Google Scholar | |
|
Shoji K, Murayama T, Mimura I, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, et al: Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma. Am J Pathol. 182:2191–2203. 2013. View Article : Google Scholar | |
|
Elhanati S, Kanfi Y, Varvak A, Roichman A, Carmel-Gross I, Barth S, Gibor G and Cohen HY: Multiple regulatory layers of SREBP1/2 by SIRT6. Cell Rep. 4:905–912. 2013. View Article : Google Scholar | |
|
Ghosh S, Liu B, Wang Y, Hao Q and Zhou Z: Lamin A is an endogenous SIRT6 activator and promotes SIRT6-mediated DNA repair. Cell Rep. 13:1396–1406. 2015. View Article : Google Scholar | |
|
Li H, Ge C, Zhao F, Yan M, Hu C, Jia D, Tian H, Zhu M, Chen T, Jiang G, et al: Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular carcinoma. Hepatology. 54:910–919. 2011. View Article : Google Scholar | |
|
Zhao J, Liu B, Yang JA, Tang D, Wang X and Chen Q: Human sperm-associated antigen 4 as a potential biomarker of glioblastoma progression and prognosis. Neuroreport. 30:446–451. 2019. View Article : Google Scholar | |
|
Liu T, Yu J, Ge C, Zhao F, Chen J, Miao C, Jin W, Zhou Q, Geng Q, Lin H, et al: Sperm associated antigen 4 promotes SREBP1-mediated de novo lipogenesis via interaction with lamin A/C and contributes to tumor progression in hepatocellular carcinoma. Cancer Lett. 536:2156422022. View Article : Google Scholar | |
|
Eferl R and Wagner EF: AP-1: A double-edged sword in tumorigenesis. Nat Rev Cancer. 3:859–868. 2003. View Article : Google Scholar | |
|
Shaulian E and Karin M: AP-1 as a regulator of cell life and death. Nat Cell Biol. 4:E131–E136. 2002. View Article : Google Scholar | |
|
Ding Y, Hao K, Li Z, Ma R, Zhou Y, Zhou Z, Wei M, Liao Y, Dai Y, Yang Y, et al: c-Fos separation from Lamin A/C by GDF15 promotes colon cancer invasion and metastasis in inflammatory microenvironment. J Cell Physiol. 235:4407–4421. 2020. View Article : Google Scholar | |
|
Sharma P and Kuehn MR: SENP1-modulated sumoylation regulates retinoblastoma protein (RB) and Lamin A/C interaction and stabilization. Oncogene. 35:6429–6438. 2016. View Article : Google Scholar | |
|
Elenbaas JS, Bragazzi Cunha J, Azuero-Dajud R, Nelson B, Oral EA, Williams JA, Stewart CL and Omary MB: Lamin A/C maintains exocrine pancreas homeostasis by regulating stability of RB and activity of E2F. Gastroenterology. 154:1625–1629.e8. 2018. View Article : Google Scholar |
