Open Access

Epigenetic regulatory mechanism of macrophage polarization in diabetic wound healing (Review)

  • Authors:
    • Jielin Song
    • Yuqing Wu
    • Yunli Chen
    • Xu Sun
    • Zhaohui Zhang
  • View Affiliations

  • Published online on: October 18, 2024     https://doi.org/10.3892/mmr.2024.13367
  • Article Number: 2
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Diabetic wounds represent a significant complication of diabetes and present a substantial challenge to global public health. Macrophages are crucial effector cells that play a pivotal role in the pathogenesis of diabetic wounds, through their polarization into distinct functional phenotypes. The field of epigenetics has emerged as a rapidly advancing research area, as this phenomenon has the potential to markedly affect gene expression, cellular differentiation, tissue development and susceptibility to disease. Understanding epigenetic mechanisms is crucial to further exploring disease pathogenesis. A growing body of scientific evidence has highlighted the pivotal role of epigenetics in the regulation of macrophage phenotypes. Various epigenetic mechanisms, such as DNA methylation, histone modification and non‑coding RNAs, are involved in the modulation of macrophage phenotype differentiation in response to the various environmental stimuli present in diabetic wounds. The present review provided an overview of the various changes that take place in macrophage phenotypes and functions within diabetic wounds and discussed the emerging role of epigenetic modifications in terms of regulating macrophage plasticity in diabetic wounds. It is hoped that this synthesis of information will facilitate the elucidation of diabetic wound pathogenesis and the identification of potential therapeutic targets.
View Figures
View References

Related Articles

Journal Cover

January-2025
Volume 31 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Song J, Wu Y, Chen Y, Sun X and Zhang Z: Epigenetic regulatory mechanism of macrophage polarization in diabetic wound healing (Review). Mol Med Rep 31: 2, 2025.
APA
Song, J., Wu, Y., Chen, Y., Sun, X., & Zhang, Z. (2025). Epigenetic regulatory mechanism of macrophage polarization in diabetic wound healing (Review). Molecular Medicine Reports, 31, 2. https://doi.org/10.3892/mmr.2024.13367
MLA
Song, J., Wu, Y., Chen, Y., Sun, X., Zhang, Z."Epigenetic regulatory mechanism of macrophage polarization in diabetic wound healing (Review)". Molecular Medicine Reports 31.1 (2025): 2.
Chicago
Song, J., Wu, Y., Chen, Y., Sun, X., Zhang, Z."Epigenetic regulatory mechanism of macrophage polarization in diabetic wound healing (Review)". Molecular Medicine Reports 31, no. 1 (2025): 2. https://doi.org/10.3892/mmr.2024.13367