Open Access

Peroxisome proliferator‑activated receptor γ coactivator‑1α in heart disease (Review)

  • Authors:
    • Siyu Sun
    • Huige Guo
    • Guohui Chen
    • Hui Zhang
    • Zhanrui Zhang
    • Xiulong Wang
    • Dongxu Li
    • Xuefang Li
    • Guoan Zhao
    • Fei Lin
  • View Affiliations

  • Published online on: November 4, 2024     https://doi.org/10.3892/mmr.2024.13382
  • Article Number: 17
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Heart disease (HD) is a general term for various diseases affecting the heart. An increasing body of evidence suggests that the pathogenesis of HD is closely related to mitochondrial dysfunction. Peroxisome proliferator‑activated receptor γ coactivator‑1α (PGC‑1α) is a transcriptional coactivator that plays an important role in mitochondrial function by regulating mitochondrial biogenesis, energy metabolism and oxidative stress. The present review shows that PGC‑1α expression and activity in the heart are controlled by multiple signaling pathways, including adenosine monophosphate‑activated protein kinase, sirtuin 1/3 and nuclear factor κB. These can mediate the activation or inhibition of transcription and post‑translational modifications (such as phosphorylation and acetylation) of PGC‑1α. Furthermore, it highlighted the recent progress of PGC‑1α in HD, including heart failure, coronary heart disease, diabetic cardiomyopathy, drug‑induced cardiotoxicity and arrhythmia. Understanding the mechanisms underlying PGC‑1α in response to pathological stimulation may prove to be beneficial in developing new ideas and strategies for preventing and treating HDs. Meanwhile, the present review explored why the opposite results occurred when PGC‑1α was used as a target therapy.
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January-2025
Volume 31 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Sun S, Guo H, Chen G, Zhang H, Zhang Z, Wang X, Li D, Li X, Zhao G, Lin F, Lin F, et al: Peroxisome proliferator‑activated receptor γ coactivator‑1α in heart disease (Review). Mol Med Rep 31: 17, 2025.
APA
Sun, S., Guo, H., Chen, G., Zhang, H., Zhang, Z., Wang, X. ... Lin, F. (2025). Peroxisome proliferator‑activated receptor γ coactivator‑1α in heart disease (Review). Molecular Medicine Reports, 31, 17. https://doi.org/10.3892/mmr.2024.13382
MLA
Sun, S., Guo, H., Chen, G., Zhang, H., Zhang, Z., Wang, X., Li, D., Li, X., Zhao, G., Lin, F."Peroxisome proliferator‑activated receptor γ coactivator‑1α in heart disease (Review)". Molecular Medicine Reports 31.1 (2025): 17.
Chicago
Sun, S., Guo, H., Chen, G., Zhang, H., Zhang, Z., Wang, X., Li, D., Li, X., Zhao, G., Lin, F."Peroxisome proliferator‑activated receptor γ coactivator‑1α in heart disease (Review)". Molecular Medicine Reports 31, no. 1 (2025): 17. https://doi.org/10.3892/mmr.2024.13382