Open Access

Advances in research on malignant tumors and targeted agents for TOP2A (Review)

  • Authors:
    • Tao Zhou
    • Yiting Niu
    • Yanjun Li
  • View Affiliations

  • Published online on: December 10, 2024     https://doi.org/10.3892/mmr.2024.13415
  • Article Number: 50
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The DNA topoisomerase isoform topoisomerase IIα (TOP2A) is essential for the condensation and segregation of cellular mitotic chromosomes and the structural maintenance. It has been demonstrated that TOP2A is highly expressed in various malignancies, including lung adenocarcinoma (LUAD), hepatocellular carcinoma (HCC) and breast cancer (BC), associating with poor prognosis and aggressive tumor behavior. Additionally, TOP2A has emerged as a promising target for cancer therapy, with widespread clinical application of associated chemotherapeutic agents. The present study explored the impact of TOP2A on malignant tumor growth and the advancements in research on its targeted drugs. The fundamental mechanisms of TOP2A have been detailed, its specific roles in tumor cells are analyzed, and its potential as a biomarker for tumor prognosis and therapeutic targeting is highlighted. Additionally, the present review compiles findings from the latest clinical trials of relevant targeted agents, information on newly developed inhibitors, and discusses future research directions and clinical application strategies in cancer therapy, aiming to propose novel ideas and methods.
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February-2025
Volume 31 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou T, Niu Y and Li Y: Advances in research on malignant tumors and targeted agents for TOP2A (Review). Mol Med Rep 31: 50, 2025.
APA
Zhou, T., Niu, Y., & Li, Y. (2025). Advances in research on malignant tumors and targeted agents for TOP2A (Review). Molecular Medicine Reports, 31, 50. https://doi.org/10.3892/mmr.2024.13415
MLA
Zhou, T., Niu, Y., Li, Y."Advances in research on malignant tumors and targeted agents for TOP2A (Review)". Molecular Medicine Reports 31.2 (2025): 50.
Chicago
Zhou, T., Niu, Y., Li, Y."Advances in research on malignant tumors and targeted agents for TOP2A (Review)". Molecular Medicine Reports 31, no. 2 (2025): 50. https://doi.org/10.3892/mmr.2024.13415