Open Access

Heat shock protein 22: A new direction for cardiovascular disease (Review)

  • Authors:
    • Yi Chen
    • Meng Li
    • Yanqing Wu
  • View Affiliations

  • Published online on: January 27, 2025     https://doi.org/10.3892/mmr.2025.13447
  • Article Number: 82
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Small heat shock proteins (sHSPs) are common molecular chaperone proteins that function in various biological processes, and serve indispensable roles in maintaining cellular protein homeostasis and regulating the hydrolysis of unfolded proteins. HSP22 is a member of the sHSP family that is primarily expressed in the heart and skeletal muscle, as well as in various types of cancer. There have been important findings concerning the role of HSP22 in cardiovascular diseases. The aim of the present study was to provide insights into the various molecular mechanisms by which HSP22 functions in the heart, including oxidative stress, autophagy, apoptosis, the subcellular distribution of proteins and the promoting effect of proteasomes. In addition, drugs and cytokines, including geranylgeranylacetone, can exert protective effects on the heart by regulating the expression of HSP22. Based on increasingly abundant research, HSP22 may be considered a potential therapeutic target in cardiovascular diseases.
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March-2025
Volume 31 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Y, Li M and Wu Y: Heat shock protein 22: A new direction for cardiovascular disease (Review). Mol Med Rep 31: 82, 2025.
APA
Chen, Y., Li, M., & Wu, Y. (2025). Heat shock protein 22: A new direction for cardiovascular disease (Review). Molecular Medicine Reports, 31, 82. https://doi.org/10.3892/mmr.2025.13447
MLA
Chen, Y., Li, M., Wu, Y."Heat shock protein 22: A new direction for cardiovascular disease (Review)". Molecular Medicine Reports 31.3 (2025): 82.
Chicago
Chen, Y., Li, M., Wu, Y."Heat shock protein 22: A new direction for cardiovascular disease (Review)". Molecular Medicine Reports 31, no. 3 (2025): 82. https://doi.org/10.3892/mmr.2025.13447