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Review Open Access

Application of non‑coding RNAs in tumors (Review)

  • Authors:
    • Zhihan Zhang
    • Chunyan Mao
    • Yi Wu
    • Yin Wang
    • Hui Cong
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 164
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    Published online on: April 11, 2025
       https://doi.org/10.3892/mmr.2025.13529
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Abstract

Tumors are associated with the highest mortality rates worldwide. For more than a decade, research has focused on the genetic involvement of proteins in cancer; however, a complete class of molecular non‑coding (nc)RNAs have been discovered in recent years, and these are considered to be associated with cancer. Notably, ncRNAs are highly conserved and multifunctional. These interact with multiple signaling pathways, influencing cell cycle progression and various physiological processes. Therefore, the present review aimed to investigate ncRNA, microRNA, transfer RNA‑derived small RNA, PIWI‑interacting RNA and long non‑coding RNA to further understand the associated generation processes, functional mechanisms and therapeutic roles in tumors. The present review demonstrated the critical role of ncRNAs in tumors, and may provide a novel theoretical basis for the role of ncRNAs as biomarkers or therapeutic tools in the treatment of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Mao C, Wu Y, Wang Y and Cong H: Application of non‑coding RNAs in tumors (Review). Mol Med Rep 31: 164, 2025.
APA
Zhang, Z., Mao, C., Wu, Y., Wang, Y., & Cong, H. (2025). Application of non‑coding RNAs in tumors (Review). Molecular Medicine Reports, 31, 164. https://doi.org/10.3892/mmr.2025.13529
MLA
Zhang, Z., Mao, C., Wu, Y., Wang, Y., Cong, H."Application of non‑coding RNAs in tumors (Review)". Molecular Medicine Reports 31.6 (2025): 164.
Chicago
Zhang, Z., Mao, C., Wu, Y., Wang, Y., Cong, H."Application of non‑coding RNAs in tumors (Review)". Molecular Medicine Reports 31, no. 6 (2025): 164. https://doi.org/10.3892/mmr.2025.13529
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Mao C, Wu Y, Wang Y and Cong H: Application of non‑coding RNAs in tumors (Review). Mol Med Rep 31: 164, 2025.
APA
Zhang, Z., Mao, C., Wu, Y., Wang, Y., & Cong, H. (2025). Application of non‑coding RNAs in tumors (Review). Molecular Medicine Reports, 31, 164. https://doi.org/10.3892/mmr.2025.13529
MLA
Zhang, Z., Mao, C., Wu, Y., Wang, Y., Cong, H."Application of non‑coding RNAs in tumors (Review)". Molecular Medicine Reports 31.6 (2025): 164.
Chicago
Zhang, Z., Mao, C., Wu, Y., Wang, Y., Cong, H."Application of non‑coding RNAs in tumors (Review)". Molecular Medicine Reports 31, no. 6 (2025): 164. https://doi.org/10.3892/mmr.2025.13529
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