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Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review)

  • Authors:
    • Qiuhe Song
    • Pengfei Xu
    • Qipeng Xiao
    • Chaowen Zhang
    • Yousheng Mao
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 169
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    Published online on: April 11, 2025
       https://doi.org/10.3892/mmr.2025.13534
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Abstract

Psoriasis is a chronic systemic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and significant immune dysregulation. Obesity is markedly associated with psoriasis, acting as an independent risk factor that exacerbates disease severity and treatment failure, while weight‑reduction interventions can improve psoriatic lesions. However, the mechanisms by which obesity promotes the onset and progression of psoriatic lesions still require further elucidation. The present comprehensive narrative review highlighted the critical role of the crosstalk between white adipose tissue (WAT) and skin in the pathogenesis of psoriasis. The expansion of WAT contributes to inflammation, epidermal proliferation and angiogenesis in skin lesions through the release of adipokines, extracellular vesicles and free fatty acids. Conversely, psoriatic lesions induce dysregulation in the inflammation and function of WAT. These findings suggested that this bidirectional communication not only explains the high prevalence of obesity among patients with psoriasis, but also highlights the importance of addressing metabolic comorbidities in treatment strategies. 
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Copy and paste a formatted citation
Spandidos Publications style
Song Q, Xu P, Xiao Q, Zhang C and Mao Y: Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review). Mol Med Rep 31: 169, 2025.
APA
Song, Q., Xu, P., Xiao, Q., Zhang, C., & Mao, Y. (2025). Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review). Molecular Medicine Reports, 31, 169. https://doi.org/10.3892/mmr.2025.13534
MLA
Song, Q., Xu, P., Xiao, Q., Zhang, C., Mao, Y."Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review)". Molecular Medicine Reports 31.6 (2025): 169.
Chicago
Song, Q., Xu, P., Xiao, Q., Zhang, C., Mao, Y."Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review)". Molecular Medicine Reports 31, no. 6 (2025): 169. https://doi.org/10.3892/mmr.2025.13534
Copy and paste a formatted citation
x
Spandidos Publications style
Song Q, Xu P, Xiao Q, Zhang C and Mao Y: Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review). Mol Med Rep 31: 169, 2025.
APA
Song, Q., Xu, P., Xiao, Q., Zhang, C., & Mao, Y. (2025). Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review). Molecular Medicine Reports, 31, 169. https://doi.org/10.3892/mmr.2025.13534
MLA
Song, Q., Xu, P., Xiao, Q., Zhang, C., Mao, Y."Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review)". Molecular Medicine Reports 31.6 (2025): 169.
Chicago
Song, Q., Xu, P., Xiao, Q., Zhang, C., Mao, Y."Crosstalk between white adipose tissue and skin: Unraveling its role in psoriasis pathogenesis (Review)". Molecular Medicine Reports 31, no. 6 (2025): 169. https://doi.org/10.3892/mmr.2025.13534
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