Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2025 Volume 32 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2025 Volume 32 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Action and mechanisms of neferine in inflammatory diseases (Review)

  • Authors:
    • Qin Zhang
    • Qiaoling Zhou
    • Huihui Li
  • View Affiliations / Copyright

    Affiliations: Department of Nephropathy, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, P.R. China, Department of Nephropathy, Xiangya Hospital Central‑South University, Changsha, Hunan 410028, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 174
    |
    Published online on: April 16, 2025
       https://doi.org/10.3892/mmr.2025.13539
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Neferine is a bisbenzylisoquinoline alkaloid derived from the seed embryo of Nelumbo nucifera, a traditional Chinese medicine. It has been extensively studied for its therapeutic potential in various disease models. Extensive research has highlighted its diverse pharmacological activities, including antitumor, anti‑inflammatory, anti‑fibrosis, anti‑oxidative stress, anti‑platelet aggregation and anti‑arrhythmic effects. The present review, however, focuses on the anti‑inflammatory properties of neferine, emphasizing its fundamental mechanisms as demonstrated in both in vivo and in vitro studies. By critically evaluating its effect on inflammation and the underlying pathways, this review aims to provide a comprehensive understanding of the potential of neferine in the management of inflammatory diseases. Furthermore, it seeks to establish a foundational framework for the future development of neferine as a novel therapeutic agent for inflammatory conditions.
View Figures

Figure 1

Figure 2

View References

1 

Mukherjee PK, Mukherjee D, Maji AK, Rai S and Heinrich M: The sacred lotus (Nelumbo nucifera)-phytochemical and therapeutic profile. J Pharm Pharmacol. 61:407–422. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Sharma BR, Gautam LN, Adhikari D and Karki R: A Comprehensive review on chemical profiling of nelumbo nucifera: Potential for drug development. Phytother Res. 31:3–26. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Zhao SH, Jin D, Gu CJ and Lian FG: Professor Tong Xiaolin's experience in using lotus leaf, gordon euryale seed and lotus plumule for clearing and transforming damp-heat symptoms. Jilin J Trad Chin Med. 41:336–338. 2021.(In Chinese).

4 

Huang XX, Xie Z, Xie MY and Li S: Mechanism of qinggongtang against generalized anxiety disorder based on Glu/GABA metabolic balance. Chin J Exp Trad Med Formulae. 30:28–35. 2024.(In Chinese).

5 

Zheng ZJ, Zhu LZ, Song WC, Hu C, Chen S, You P and Zhou Y: Pharmacological Research Progress of Nelumbinis Plumula in the Treatment of Insomnia from the Traditional Chinese Medicine Perspective ‘Heart Mind’. Shenzhen J Integrated Trad Chin Western Med. 32:125–129. 2022.(In Chinese).

6 

Wang Z, Li Y, Ma D, Zeng M, Wang Z, Qin F, Chen J, Christian M and He Z: Alkaloids from lotus (Nelumbo nucifera): Recent advances in biosynthesis, pharmacokinetics, bioactivity, safety, and industrial applications. Crit Rev Food Sci Nutr. 63:4867–4900. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Bishayee A, Patel PA, Sharma P, Thoutireddy S and Das N: Lotus (Nelumbo nucifera Gaertn.) and its bioactive phytocompounds: A tribute to cancer prevention and intervention. Cancers (Basel). 14:5292022. View Article : Google Scholar : PubMed/NCBI

8 

Marthandam Asokan S, Mariappan R, Muthusamy S and Velmurugan BK: Pharmacological benefits of neferine-A comprehensive review. Life Sci. 199:60–70. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Bharathi Priya L, Huang CY, Hu RM, Balasubramanian B and Baskaran R: An updated review on pharmacological properties of neferine-A bisbenzylisoquinoline alkaloid from Nelumbo nucifera. J Food Biochem. 45:e139862021. View Article : Google Scholar : PubMed/NCBI

10 

Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME and Kumar SS: Role of antioxidants and natural products in inflammation. Oxid Med Cell Longev. 2016:52761302016. View Article : Google Scholar : PubMed/NCBI

11 

Priya LB, Baskaran R, Huang CY and Padma VV: Neferine ameliorates cardiomyoblast apoptosis induced by doxorubicin: Possible role in modulating NADPH oxidase/ROS-mediated NFκB redox signaling cascade. Sci Rep. 7:122832017. View Article : Google Scholar : PubMed/NCBI

12 

Jarczak D and Nierhaus A: Cytokine Storm-definition, causes, and implications. Int J Mol Sci. 23:117402022. View Article : Google Scholar : PubMed/NCBI

13 

van Loo G and Bertrand MJM: Death by TNF: A road to inflammation. Nat Rev Immunol. 23:289–303. 2023. View Article : Google Scholar : PubMed/NCBI

14 

Pan Y, Cai B, Wang K, Wang S, Zhou S, Yu X, Xu B and Chen L: Neferine enhances insulin sensitivity in insulin resistant rats. J Ethnopharmacol. 124:98–102. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Baskaran R, Priya LB, Kalaiselvi P, Poornima P, Huang CY and Padma VV: Neferine from Nelumbo nucifera modulates oxidative stress and cytokines production during hypoxia in human peripheral blood mononuclear cells. Biomed Pharmacother. 93:730–736. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Min X, Guo Y, Zhou Y and Chen X: Protection against dextran sulfate Sodium-induced ulcerative colitis in mice by neferine, a natural product from Nelumbo nucifera gaertn. Cell J. 22:523–531. 2021.PubMed/NCBI

17 

Li J, Chou H, Li L, Li H and Cui Z: Wound healing activity of neferine in experimental diabetic rats through the inhibition of inflammatory cytokines and nrf-2 pathway. Artif Cells Nanomed Biotechnol. 48:96–106. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Rietschel ET, Kirikae T, Schade FU, Mamat U, Schmidt G, Loppnow H, Ulmer AJ, Zähringer U, Seydel U, Di Padova F, et al: Bacterial endotoxin: Molecular relationships of structure to activity and function. FASEB J. 8:217–225. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Wu X, Guo Y, Min X, Pei L and Chen X: Neferine, a bisbenzylisoquinoline alkaloid, ameliorates dextran sulfate Sodium-induced ulcerative colitis. Am J Chin Med. 46:1263–1279. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Guolan D, Lingli W, Wenyi H, Wei Z, Baowei C and Sen B: Anti-inflammatory effects of neferine on LPS-induced human endothelium via MAPK, and NF-κβ pathways. Pharmazie. 73:541–544. 2018.PubMed/NCBI

21 

Liu XY, Xu HX, Li JK, Zhang D, Ma XH, Huang LN, Lü JH and Wang XZ: Neferine Protects endothelial glycocalyx via mitochondrial ROS in lipopolysaccharide-Induced acute respiratory distress syndrome. Front Physiol. 9:1022018. View Article : Google Scholar : PubMed/NCBI

22 

Tang YS, Zhao YH, Zhong Y, Li XZ, Pu JX, Luo YC and Zhou QL: Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway. Inflamm Res. 68:727–738. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Zhong Y, He S, Huang K and Liang M: Neferine suppresses vascular endothelial inflammation by inhibiting the NF-κB signaling pathway. Arch Biochem Biophys. 696:1085952020. View Article : Google Scholar : PubMed/NCBI

24 

Li H, Chen W, Chen Y, Zhou Q, Xiao P, Tang R and Xue J: Neferine attenuates acute kidney injury by inhibiting NF-κB signaling and upregulating klotho expression. Front Pharmacol. 10:11972019. View Article : Google Scholar : PubMed/NCBI

25 

Li T, Zhai YX, Zheng T and Xu B: Neferine exerts anti-inflammatory activity in BV-2 microglial cells and protects mice with MPTP-induced Parkinson's disease by inhibiting NF-κB activation. Mol Med Rep. 28:2352023. View Article : Google Scholar : PubMed/NCBI

26 

Qi Z, Wang R, Liao R, Xue S and Wang Y: Neferine ameliorates Sepsis-induced myocardial dysfunction through Anti-apoptotic and antioxidative effects by regulating the PI3K/AKT/mTOR signaling pathway. Front Pharmacol. 12:7062512021. View Article : Google Scholar : PubMed/NCBI

27 

Savin IA, Zenkova MA and Sen'kova AV: Pulmonary fibrosis as a result of acute lung inflammation: Molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches. Int J Mol Sci. 23:149592022. View Article : Google Scholar : PubMed/NCBI

28 

Zhao L, Wang X, Chang Q, Xu J, Huang Y, Guo Q, Zhang S, Wang W, Chen X and Wang J: Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis. Eur J Pharmacol. 627:304–312. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Niu CH, Wang Y, Liu JD, Wang JL and Xiao JH: Protective effects of neferine on amiodarone-induced pulmonary fibrosis in mice. Eur J Pharmacol. 714:112–119. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Wang Y, Wang S, Wang R, Li S and Yuan Y: Neferine exerts antioxidant and Anti-inflammatory effects on carbon Tetrachloride-induced liver fibrosis by inhibiting the MAPK and NF-κB/IκBα pathways. Evid Based Complement Alternat Med. 2021:41360192021.PubMed/NCBI

31 

Joffre J and Hellman J: Oxidative stress and endothelial dysfunction in sepsis and acute inflammation. Antioxid Redox Signal. 35:1291–1307. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Hussain T, Tan B, Yin Y, Blachier F, Tossou MCB and Rahu N: Oxidative stress and inflammation: What polyphenols can do for us? Oxid Med Cell Longev. 2016:74327972016. View Article : Google Scholar : PubMed/NCBI

33 

Lalitha G, Poornima P, Archanah A and Padma VV: Protective effect of neferine against isoproterenol-induced cardiac toxicity. Cardiovasc Toxicol. 13:168–179. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Guan G, Han H, Yang Y, Jin Y, Wang X and Liu X: Neferine prevented hyperglycemia-induced endothelial cell apoptosis through suppressing ROS/Akt/NF-κB signal. Endocrine. 47:764–771. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Khan A, Bai H, Shu M, Chen M, Khan A and Bai Z: Antioxidative and antiphotoaging activities of neferine upon UV-A irradiation in human dermal fibroblasts. Biosci Rep. 38:BSR201814142018. View Article : Google Scholar : PubMed/NCBI

36 

Khan A, Bai H, Khan A and Bai Z: Neferine prevents ultraviolet radiation-induced skin photoaging. Exp Ther Med. 19:3189–3196. 2020.PubMed/NCBI

37 

Nguyen T, Nioi P and Pickett CB: The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 284:13291–13295. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Baskaran R, Poornima P, Priya LB, Huang CY and Padma VV: Neferine prevents autophagy induced by hypoxia through activation of Akt/mTOR pathway and Nrf2 in muscle cells. Biomed Pharmacother. 83:1407–1413. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Bharathi Priya L, Baskaran R, Huang CY and Vijaya Padma V: Neferine modulates IGF-1R/Nrf2 signaling in doxorubicin treated H9c2 cardiomyoblasts. J Cell Biochem. 119:1441–1452. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Liu XD, Li H, Wang CZ, Zhao HD and Xiao P: Mechanism of neferine in antioxidant stress. China J Modern Med. 28:31–36. 2018.

41 

Wu C, Chen J, Yang R, Duan F, Li S and Chen X: Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke. Br J Pharmacol. 176:400–415. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Jiang XX, Zhang R and Wang HS: Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways. Aging. 16:8630–8644. 2024. View Article : Google Scholar : PubMed/NCBI

43 

Sanz AB, Sanchez-Niño MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M, Egido J and Ortiz A: NF-kappaB in renal inflammation. J Am Soc Nephrol. 21:1254–1262. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Yu H, Lin L, Zhang Z, Zhang H and Hu H: Targeting NF-κB pathway for the therapy of diseases: Mechanism and clinical study. Signal Transduct Target Ther. 5:2092020. View Article : Google Scholar : PubMed/NCBI

45 

Jung HA, Jin SE, Choi RJ, Kim DH, Kim YS, Ryu JH, Kim DW, Son YK, Park JJ and Choi JS: Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1. Life Sci. 87:420–430. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Chen S, Chu B, Chen Y, Cheng X, Guo D, Chen L, Wang J, Li Z, Hong Z and Hong D: Neferine suppresses osteoclast differentiation through suppressing NF-κB signal pathway but not MAPKs and promote osteogenesis. J Cell Physiol. 234:22960–22971. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Wu F, Wu Z, Ye Z, Niu G, Ma Z and Zhang P: PLGA/BGP/Nef porous composite restrains osteoclasts by inhibiting the NF-κB pathway, enhances IGF-1-mediated osteogenic differentiation and promotes bone regeneration. J Biol Eng. 17:452023. View Article : Google Scholar : PubMed/NCBI

48 

Ni B, Huang X, Xi Y, Mao Z, Chu X, Zhang R, Ma X and You H: Neferine inhibits expression of inflammatory mediators and matrix degrading enzymes in IL-1β-treated rat chondrocytes via suppressing MAPK and NF-κB signaling pathways. Inflammation. 43:1209–1221. 2020. View Article : Google Scholar : PubMed/NCBI

49 

Luo MC, Zhou SY, Feng DY, Xiao J, Li WY, Xu CD, Wang HY and Zhou T: Runt-related transcription factor 1 (RUNX1) binds to p50 in macrophages and enhances TLR4-triggered inflammation and septic shock. J Biol Chem. 291:22011–22020. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Wang MY, Zhang SS, An MF, Xia YF, Fan MS, Sun ZR, Zhang LJ, Zhao YL, Sheng J and Wang XJ: Neferine ameliorates nonalcoholic steatohepatitis through regulating AMPK pathway. Phytomedicine. 114:1547982023. View Article : Google Scholar : PubMed/NCBI

51 

Xiong Y, Zhong J, Chen W, Li X, Liu H, Li Y, Xiong W and Li H: Neferine alleviates acute kidney injury by regulating the PPAR-α/NF-κB pathway. Clin Exp Nephrol. 28:969–987. 2024. View Article : Google Scholar : PubMed/NCBI

52 

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X and Zhao L: Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9:7204–7218. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Kim EK and Choi EJ: Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 1802:396–405. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K and Cobb MH: Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr Rev. 22:153–183. 2001. View Article : Google Scholar : PubMed/NCBI

55 

Liu X, Song X, Lu J, Chen X, Liang E, Liu X, Zhang M, Zhang Y, Du Z and Zhao Y: Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice. Oncotarget. 7:61703–61715. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Ozal SA, Gurlu V, Turkekul K, Guclu H and Erdogan S: Neferine inhibits epidermal growth factor-induced proliferation and migration of retinal pigment epithelial cells through downregulating p38 MAPK and PI3K/AKT signalling. Cutan Ocul Toxicol. 39:97–105. 2020. View Article : Google Scholar : PubMed/NCBI

57 

Zhu T, Xiao X, Dong Y and Yuan C: Neferine alleviates ovalbumin-induced asthma via MAPK signaling pathways in mice. Allergol Immunopathol (Madr). 51:135–142. 2023. View Article : Google Scholar : PubMed/NCBI

58 

Han Q, Li H, Zhao F, Gao J, Liu X and Ma B: Auricularia auricula peptides nutritional supplementation delays H2O2-induced senescence of hepG2 cells by modulation of MAPK/NF-κB signaling pathways. Nutrients. 15:37312023. View Article : Google Scholar : PubMed/NCBI

59 

Yang CC, Hung YL, Ko WC, Tsai YJ, Chang JF, Liang CW, Chang DC and Hung CF: Effect of neferine on DNCB-induced atopic dermatitis in HaCaT cells and BALB/c Mice. Int J Mol Sci. 22:82372021. View Article : Google Scholar : PubMed/NCBI

60 

Chiu KM, Hung YL, Wang SJ, Tsai YJ, Wu NL, Liang CW, Chang DC and Hung CF: Anti-allergic and Anti-inflammatory effects of neferine on RBL-2H3 cells. Int J Mol Sci. 22:109942021. View Article : Google Scholar : PubMed/NCBI

61 

Wang L and Hauenstein AV: The NLRP3 inflammasome: Mechanism of action, role in disease and therapies. Mol Aspects Med. 76:1008892020. View Article : Google Scholar : PubMed/NCBI

62 

Coll RC, Schroder K and Pelegrín P: NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends Pharmacol Sci. 43:653–668. 2022. View Article : Google Scholar : PubMed/NCBI

63 

Wu XL, Deng MZ, Gao ZJ, Dang YY, Li YC and Li CW: Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress. Int Immunopharmacol. 84:1065592020. View Article : Google Scholar : PubMed/NCBI

64 

Zhu JJ, Yu BY, Huang XK, He MZ, Chen BW, Chen TT, Fang HY, Chen SQ, Fu XQ, Li PJ, et al: Neferine protects against Hypoxic-ischemic brain damage in neonatal rats by suppressing NLRP3-mediated inflammasome activation. Oxid Med Cell Longev. 2021:66549542021. View Article : Google Scholar : PubMed/NCBI

65 

Zheng ZJ, Zhu LZ, Qiu H, Zheng WY, You PT, Chen SH, Hu CL, Huang JR and Zhou YJ: Neferine inhibits BMECs pyroptosis and maintains blood-brain barrier integrity in ischemic stroke by triggering a cascade reaction of PGC-1α. Sci Rep. 14:144382024. View Article : Google Scholar : PubMed/NCBI

66 

Lin TY, Hung CY, Chiu KM, Lee MY, Lu CW and Wang SJ: Neferine, an alkaloid from lotus seed embryos, exerts antiseizure and neuroprotective effects in a kainic Acid-induced seizure model in rats. Int J Mol Sci. 23:41302022. View Article : Google Scholar : PubMed/NCBI

67 

Deretic V: Autophagy in inflammation, infection, and immunometabolism. Immunity. 54:437–453. 2021. View Article : Google Scholar : PubMed/NCBI

68 

Xu T, Singh D, Liu J, Li H, Peng S, Rizzolo LJ and Wang SB: Neferine, is not inducer but blocker for macroautophagic flux targeting on lysosome malfunction. Biochem Biophys Res Commun. 495:1516–1521. 2018. View Article : Google Scholar : PubMed/NCBI

69 

Sengking J, Oka C, Wicha P, Yawoot N, Tocharus J, Chaichompoo W, Suksamrarn A and Tocharus C: Neferine protects against brain damage in permanent cerebral ischemic rat associated with autophagy suppression and AMPK/mTOR regulation. Mol Neurobiol. 58:6304–6315. 2021. View Article : Google Scholar : PubMed/NCBI

70 

Li H, Tang Y, Wen L, Kong X, Chen X, Liu P, Zhou Z, Chen W, Xiao C, Xiao P and Xiao X: Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy via the AMPK/mTOR signaling pathway. Biochem Biophys Res Commun. 484:694–701. 2017. View Article : Google Scholar : PubMed/NCBI

71 

Jones SA, Mills KH and Harris J: Autophagy and inflammatory diseases. Immunol Cell Biol. 91:250–258. 2013. View Article : Google Scholar : PubMed/NCBI

72 

Yang Z, Goronzy JJ and Weyand CM: Autophagy in autoimmune disease. J Mol Med (Berl). 93:707–717. 2015. View Article : Google Scholar : PubMed/NCBI

73 

Li H, Gao L, Min J, Yang Y and Zhang R: Neferine suppresses autophagy-induced inflammation, oxidative stress and adipocyte differentiation in Graves' orbitopathy. J Cell Mol Med. 25:1949–1957. 2021. View Article : Google Scholar : PubMed/NCBI

74 

Jiang T, Harder B, Rojo de la Vega M, Wong PK, Chapman E and Zhang DD: p62 links autophagy and Nrf2 signaling. Free Radic Biol Med. 88:199–204. 2015. View Article : Google Scholar : PubMed/NCBI

75 

Heldin CH, Miyazono K and ten Dijke P: TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature. 390:465–471. 1997. View Article : Google Scholar : PubMed/NCBI

76 

Xu P, Liu J and Derynck R: Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Lett. 586:1871–1884. 2012. View Article : Google Scholar : PubMed/NCBI

77 

Dumbrava MG, Lacanlale JL, Rowan CJ and Rosenblum ND: Transforming growth factor beta signaling functions during mammalian kidney development. Pediatr Nephrol. 36:1663–1672. 2021. View Article : Google Scholar : PubMed/NCBI

78 

Goumans MJ and Ten Dijke P: TGF-β signaling in control of cardiovascular function. Cold Spring Harb Perspect Biol. 10:a0222102018. View Article : Google Scholar : PubMed/NCBI

79 

Laudisi F, Stolfi C, Monteleone I and Monteleone G: TGF-β1 signaling and Smad7 control T-cell responses in health and immune-mediated disorders. Eur J Immunol. 53:e23504602023. View Article : Google Scholar : PubMed/NCBI

80 

Xia Y, Guo Y, Zhou J, Fan L, Xie J, Wang Y, Du H and Ni X: Neferine mediated TGF-β/ERK signaling to inhibit fibrosis in endometriosis. Am J Transl Res. 15:3240–3253. 2023.PubMed/NCBI

81 

Liu CM, Shao Z, Chen X, Chen H, Su M, Zhang Z, Wu Z, Zhang P, An L, Jiang Y and Ouyang AJ: Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGF-β/Smad signaling pathways. Saudi Pharm J. 31:1219–1228. 2023. View Article : Google Scholar : PubMed/NCBI

82 

Zeng W, Zhang X, Lu Y, Wen Y, Xie Q, Yang X, He S, Guo Z, Li J, Shen A and Peng J: Neferine ameliorates hypertensive vascular remodeling modulating multiple signaling pathways in spontaneously hypertensive rats. Biomed Pharmacother. 158:1142032023. View Article : Google Scholar : PubMed/NCBI

83 

Yu Y, Sun S, Wang S, Zhang Q, Li M, Lan F, Li S and Liu C: Liensinine- and Neferine-induced cardiotoxicity in primary neonatal rat cardiomyocytes and Human-induced pluripotent stem Cell-derived cardiomyocytes. Int J Mol Sci. 17:1862016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Zhou Q and Li H: Action and mechanisms of neferine in inflammatory diseases (Review). Mol Med Rep 32: 174, 2025.
APA
Zhang, Q., Zhou, Q., & Li, H. (2025). Action and mechanisms of neferine in inflammatory diseases (Review). Molecular Medicine Reports, 32, 174. https://doi.org/10.3892/mmr.2025.13539
MLA
Zhang, Q., Zhou, Q., Li, H."Action and mechanisms of neferine in inflammatory diseases (Review)". Molecular Medicine Reports 32.1 (2025): 174.
Chicago
Zhang, Q., Zhou, Q., Li, H."Action and mechanisms of neferine in inflammatory diseases (Review)". Molecular Medicine Reports 32, no. 1 (2025): 174. https://doi.org/10.3892/mmr.2025.13539
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Zhou Q and Li H: Action and mechanisms of neferine in inflammatory diseases (Review). Mol Med Rep 32: 174, 2025.
APA
Zhang, Q., Zhou, Q., & Li, H. (2025). Action and mechanisms of neferine in inflammatory diseases (Review). Molecular Medicine Reports, 32, 174. https://doi.org/10.3892/mmr.2025.13539
MLA
Zhang, Q., Zhou, Q., Li, H."Action and mechanisms of neferine in inflammatory diseases (Review)". Molecular Medicine Reports 32.1 (2025): 174.
Chicago
Zhang, Q., Zhou, Q., Li, H."Action and mechanisms of neferine in inflammatory diseases (Review)". Molecular Medicine Reports 32, no. 1 (2025): 174. https://doi.org/10.3892/mmr.2025.13539
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team