Sensitivity of liver metabolism in jerboa (Jaculus orientalis) to ciprofibrate, a peroxisome proliferator

  • Authors:
    • Driss Mountassif
    • Mostafa Kabine
    • Karima Mounchid
    • Khadija Mounaji
    • Norbert Latruffe
    • M'Hammed Saïd El Kebbaj
  • View Affiliations

  • Published online on: July 1, 2009     https://doi.org/10.3892/mmr_00000143
  • Pages: 597-602
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Ciprofibrate is a well-known drug used to normalize lipid parameters and fibrinogen in atherosclerosis patients. In laboratory rodents such as rats or mice, ciprofibrate exhibits peroxisome proliferator activity. However, to date, no clear alterations or side effects caused by ciprofibrate have been noted in humans. In order to further investigate such possible relationships, we studied the effects of sustained ciprofibrate treatment in jerboas (Jaculus orientalis). In these rodents, ciprofibrate does not induce hepatomegaly or promote liver cell DNA replication, confirming that this species more closely resembles humans than do rats or mice. The jerboas were treated daily with ciprofibrate at 3 mg/kg body weight for 4 weeks. Subcellular markers, clinical enzymes and enzymatic antioxidant defenses were then assessed. The results showed a strong decrease in peroxisomal catalase activity and an increase in the level of malondialdehyde (a stress biomarker). Moreover, ciprofibrate in vivo and in vitro inhibited D-3-hydroxybutyrate dehydrogenase, a mitochondrial enzyme of the ketone body interconversion that is important in redox balance (NAD+/NADH+H+ ratio). In conclusion, under these conditions, ciprofibrate induced alterations in the liver oxidative metabolism.

Related Articles

Journal Cover

July-August 2009
Volume 2 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Mountassif D, Kabine M, Mounchid K, Mounaji K, Latruffe N and El Kebbaj MS: Sensitivity of liver metabolism in jerboa (Jaculus orientalis) to ciprofibrate, a peroxisome proliferator . Mol Med Rep 2: 597-602, 2009.
APA
Mountassif, D., Kabine, M., Mounchid, K., Mounaji, K., Latruffe, N., & El Kebbaj, M.S. (2009). Sensitivity of liver metabolism in jerboa (Jaculus orientalis) to ciprofibrate, a peroxisome proliferator . Molecular Medicine Reports, 2, 597-602. https://doi.org/10.3892/mmr_00000143
MLA
Mountassif, D., Kabine, M., Mounchid, K., Mounaji, K., Latruffe, N., El Kebbaj, M. S."Sensitivity of liver metabolism in jerboa (Jaculus orientalis) to ciprofibrate, a peroxisome proliferator ". Molecular Medicine Reports 2.4 (2009): 597-602.
Chicago
Mountassif, D., Kabine, M., Mounchid, K., Mounaji, K., Latruffe, N., El Kebbaj, M. S."Sensitivity of liver metabolism in jerboa (Jaculus orientalis) to ciprofibrate, a peroxisome proliferator ". Molecular Medicine Reports 2, no. 4 (2009): 597-602. https://doi.org/10.3892/mmr_00000143