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Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk

  • Authors:
    • Annica Sjölander
    • Malin E. Andersson
    • Henrik Zetterberg
    • Lennart Minthon
    • Nenad Bogdanovic
    • Kaj Blennow

  • View Affiliations

  • Published online on: November 1, 2009     https://doi.org/10.3892/mmr_00000203
  • Pages: 989-992
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Cyclin-dependent kinase 5 (cdk5) has been identified as one of the kinases that phosphorylates tau at several Alzheimer's disease (AD)-associated sites. Cdk5 is predominantly expressed in neurons, and has higher activity in AD brains than in non-demented brains. To investigate the effect of the CDK5 gene on AD, we analyzed an SNP of the CDK5 gene (rs2069456) in 347 patients with AD and in 157 controls. CDK5 genetic data was investigated in subgroups in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the CDK5 gene variants influenced biomarkers for AD.

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Journal Cover

November-December 2009
Volume 2 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
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Spandidos Publications style
Sjölander A, Andersson ME, Zetterberg H, Minthon L, Bogdanovic N and Blennow K: Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk. Mol Med Rep 2: 989-992, 2009.
APA
Sjölander, A., Andersson, M.E., Zetterberg, H., Minthon, L., Bogdanovic, N., & Blennow, K. (2009). Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk. Molecular Medicine Reports, 2, 989-992. https://doi.org/10.3892/mmr_00000203
MLA
Sjölander, A., Andersson, M. E., Zetterberg, H., Minthon, L., Bogdanovic, N., Blennow, K."Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk". Molecular Medicine Reports 2.6 (2009): 989-992.
Chicago
Sjölander, A., Andersson, M. E., Zetterberg, H., Minthon, L., Bogdanovic, N., Blennow, K."Alzheimer's disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk". Molecular Medicine Reports 2, no. 6 (2009): 989-992. https://doi.org/10.3892/mmr_00000203