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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2010 Volume 3 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway

  • Authors:
    • Dachun Yang
    • Shuangtao Ma
    • Yan Tan
    • De Li
    • Bing Tang
    • Jinsong Chen
    • Xiaohua Su
    • Gang Li
    • Xin Zhang
    • Yongjian Yang

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, General Hospital of PLA Chengdu Military Area Command, Chengdu, Sichuan 610083, P.R. China
  • Pages: 497-501
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/mmr_00000287
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Abstract

Calcineurin and its downstream effectors nuclear factor of activated T-cells 3 (NFAT3) and zinc finger-containing transcription factor (GATA4) have been implicated in the development of cardiac hypertrophy. The aims of the present study were to investigate alterations in the calcineurin/NFAT3/GATA4 pathway in pressure-overload hypertrophy, and to determine whether adrenergic receptor blockade affects this signaling pathway. In aorta-banded rats compared with sham-operated rats, a significant increase in the phosphorylation levels of calcineurin and GATA4 was observed (both p<0.05), while the NFAT3 phosphorylation level was markedly decreased (p<0.05). Oral administration of either the non-selective β blocker/α-1 blocker carvedilol or the selective β-1 blocker metoprolol, but not the selective α-1 blocker terazosin, significantly suppressed the activated calcineurin/NFAT3/GATA4 pathway (all p<0.05) in addition to inducing a regression of cardiac hypertrophy. Pressure overload-induced up-regulation of c-myc was markedly attenuated by treatment with either carvedilol or metoprolol (both p<0.05). The present findings may expand our understanding of the correlation between sympathetic activity and the calcineurin/NFAT3/GATA4 pathway, and highlight these signal transducers as effective targets in the management of pressure overload-induced cardiac hypertrophy.

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Copy and paste a formatted citation
Spandidos Publications style
Yang D, Ma S, Tan Y, Li D, Tang B, Chen J, Su X, Li G, Zhang X, Yang Y, Yang Y, et al: Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway. Mol Med Rep 3: 497-501, 2010.
APA
Yang, D., Ma, S., Tan, Y., Li, D., Tang, B., Chen, J. ... Yang, Y. (2010). Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway. Molecular Medicine Reports, 3, 497-501. https://doi.org/10.3892/mmr_00000287
MLA
Yang, D., Ma, S., Tan, Y., Li, D., Tang, B., Chen, J., Su, X., Li, G., Zhang, X., Yang, Y."Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway". Molecular Medicine Reports 3.3 (2010): 497-501.
Chicago
Yang, D., Ma, S., Tan, Y., Li, D., Tang, B., Chen, J., Su, X., Li, G., Zhang, X., Yang, Y."Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway". Molecular Medicine Reports 3, no. 3 (2010): 497-501. https://doi.org/10.3892/mmr_00000287
Copy and paste a formatted citation
x
Spandidos Publications style
Yang D, Ma S, Tan Y, Li D, Tang B, Chen J, Su X, Li G, Zhang X, Yang Y, Yang Y, et al: Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway. Mol Med Rep 3: 497-501, 2010.
APA
Yang, D., Ma, S., Tan, Y., Li, D., Tang, B., Chen, J. ... Yang, Y. (2010). Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway. Molecular Medicine Reports, 3, 497-501. https://doi.org/10.3892/mmr_00000287
MLA
Yang, D., Ma, S., Tan, Y., Li, D., Tang, B., Chen, J., Su, X., Li, G., Zhang, X., Yang, Y."Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway". Molecular Medicine Reports 3.3 (2010): 497-501.
Chicago
Yang, D., Ma, S., Tan, Y., Li, D., Tang, B., Chen, J., Su, X., Li, G., Zhang, X., Yang, Y."Adrenergic receptor blockade-induced regression of pressure-overload cardiac hypertrophy is associated with inhibition of the calcineurin/NFAT3/GATA4 pathway". Molecular Medicine Reports 3, no. 3 (2010): 497-501. https://doi.org/10.3892/mmr_00000287
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