Open Access

Pathological complete response of colorectal liver metastases following chemotherapy with S-1 and oxaliplatin (SOX) in combination with bevacizumab: A case report

  • Authors:
    • Tomoya Yokota
    • Tsuyoshi Sano
    • Yasuhiro  Shimizu
    • Daisuke  Takahari
    • Yoshiki Senda
    • Masahiro Shimura
    • Takashi Ura
    • Kohei  Shitara
    • Yuji Nimura
    • Yasushi Yatabe
    • Kei Muro
  • View Affiliations

  • Published online on: January 21, 2011     https://doi.org/10.3892/ol.2011.256
  • Pages: 201-205
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Abstract

Pathological complete response to systemic chemotherapy is associated with more favorable survival in patients with colorectal cancer liver metastases. We present a case of a 63-year-old man with multiple liver metastases from descending colon cancer. Following surgical resection of the primary tumor, the patient received systemic chemotherapy with S-1 and oxaliplatin in combination with bevacizumab. On achievement of a markedly favorable response to chemotherapy, surgical treatment of liver metastases was performed, and the liver tumors were successfully resected without any macroscopic residue. Histopathological analyses showed necrotic tissue in the complete absence of residual viable tumor cells. This is the first reported case of a patient with multiple liver metastases from descending colorectal cancer to achieve a pathological complete response following systemic chemotherapy with S-1 and oxaliplatin in combination with bevacizumab. This regimen is a systemic chemotherapy option to ‘cure’ liver metastasis from colorectal cancer.
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March-April 2011
Volume 2 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yokota T, Sano T, Shimizu Y, Takahari D, Senda Y, Shimura M, Ura T, Shitara K, Nimura Y, Yatabe Y, Yatabe Y, et al: Pathological complete response of colorectal liver metastases following chemotherapy with S-1 and oxaliplatin (SOX) in combination with bevacizumab: A case report. Oncol Lett 2: 201-205, 2011
APA
Yokota, T., Sano, T., Shimizu, Y., Takahari, D., Senda, Y., Shimura, M. ... Muro, K. (2011). Pathological complete response of colorectal liver metastases following chemotherapy with S-1 and oxaliplatin (SOX) in combination with bevacizumab: A case report. Oncology Letters, 2, 201-205. https://doi.org/10.3892/ol.2011.256
MLA
Yokota, T., Sano, T., Shimizu, Y., Takahari, D., Senda, Y., Shimura, M., Ura, T., Shitara, K., Nimura, Y., Yatabe, Y., Muro, K."Pathological complete response of colorectal liver metastases following chemotherapy with S-1 and oxaliplatin (SOX) in combination with bevacizumab: A case report". Oncology Letters 2.2 (2011): 201-205.
Chicago
Yokota, T., Sano, T., Shimizu, Y., Takahari, D., Senda, Y., Shimura, M., Ura, T., Shitara, K., Nimura, Y., Yatabe, Y., Muro, K."Pathological complete response of colorectal liver metastases following chemotherapy with S-1 and oxaliplatin (SOX) in combination with bevacizumab: A case report". Oncology Letters 2, no. 2 (2011): 201-205. https://doi.org/10.3892/ol.2011.256