A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer

  • Authors:
    • Lixin Wang
    • Daoqiang Zhang
    • Changwen Zhang
    • Shuping Zhang
    • Zhe Wang
    • Chen Qu
    • Sijin Liu
  • View Affiliations

  • Published online on: September 28, 2011     https://doi.org/10.3892/ol.2011.431
  • Pages: 119-124
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Abstract

microRNAs (miRNAs) are involved in controlling tumor behaviors either as oncogenes or tumor suppressors. To elucidate the role of miRNAs in the regulation of tumor initiation, we delineated the microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. A group of miRNAs were differentially expressed in MDA-MB‑231 and SUM1315 cells (with a high proportion of breast cancer tumor‑initiating cells, CD44+CD24-/low subpopulation) compared to MCF-7 cells (only a small proportion of CD44+CD24-/low cells). Among the differentially expressed miRNAs common to MDA-MB‑231 and SUM1315, approximately 46% of them are suggested to regulate the 'stemness' of stem cells or progenitor cells. Taken together, these findings suggested that miRNAs contribute to the maintenance of tumor‑initiating properties and indicate the potential value of the miRNA expression signature in characterizing or predicting the features (including metastasis) of breast cancer.
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January 2012
Volume 3 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang L, Zhang D, Zhang C, Zhang S, Wang Z, Qu C and Liu S: A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. Oncol Lett 3: 119-124, 2012.
APA
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., & Liu, S. (2012). A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. Oncology Letters, 3, 119-124. https://doi.org/10.3892/ol.2011.431
MLA
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., Liu, S."A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer". Oncology Letters 3.1 (2012): 119-124.
Chicago
Wang, L., Zhang, D., Zhang, C., Zhang, S., Wang, Z., Qu, C., Liu, S."A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer". Oncology Letters 3, no. 1 (2012): 119-124. https://doi.org/10.3892/ol.2011.431