Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization
- Authors:
- Xi Zhou
- Yongli Chen
- Yongmei Li
- Zhao Duan
View Affiliations
Affiliations: Department of Obstetrics and Gynecology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
- Published online on: December 28, 2011 https://doi.org/10.3892/ol.2011.542
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Pages:
659-661
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Abstract
In the present study, the case of a 34-year-old Chinese female who underwent in vitro fertilization resulting in a twin pregnancy was reported. Following in vitro fertilization, the patient was found to have a partial hydatidiform mole (PHM) with a co-existing twin by transvaginal sonography (TVS). At 16 weeks, the pregnancy was terminated and a normal-looking fetus with a HM placenta was delivered, in addition to a normal fetus with a normal placenta. Following termination of the pregnancy, the PHM progressed into an invasive mole with lung metastasis, a rare event. Serum human chorionic gonadotrophin (hCG) concentrations decreased in the first week following delivery, but over the following 21 days hCG levels showed a continuous increase. Following 2 cycles of combinative chemotherapy consisting of fluorouracil (5-FU) and dactinomycin (KSM), hCG concentrations decreased to normal levels. The patient was then administered 1 cycle of repeated chemotherapy and hCG levels remained negative for the following 2 years.
View References
|
1
|
Vassilakos P and Kajii T: Letter:
Hydatidiform mole: two entities. Lancet. 1:2591976. View Article : Google Scholar
|
|
2
|
Montes-de-Oca-Valero F, Macara L and
Shaker A: Twin pregnancy with a complete hydatidiform mole and
co-existing fetus following in-vitro fertilization: case report.
Hum Reprod. 14:2905–2907. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Lee SW, Kim MY, Chung JH, Yang JH, Lee YH
and Chun YK: Clinical findings of multiple pregnancy with a
complete hydatidiform mole and coexisting fetus. J Ultrasound Med.
29:271–280. 2010.PubMed/NCBI
|
|
4
|
Massardier J, Golfier F, Journet D, et al:
Twin pregnancy with complete hydatidiform mole and coexistent
fetus: obstetrical and oncological outcomes in a series of 14
cases. Eur J Obstet Gynecol Reprod Biol. 143:84–87. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Seckl MJ, Sebire NJ and Berkowitz RS:
Gestational trophoblastic disease. Lancet. 376:717–729. 2010.
View Article : Google Scholar
|
|
6
|
Lurain JR: Gestational trophoblastic
disease I: epidemiology, pathology, clinical presentation and
diagnosis of gestational trophoblastic disease, and management of
hydatidiform mole. Am J Obstet Gynecol. 203:531–539. 2010.
View Article : Google Scholar
|
|
7
|
Zhao Y, Zhang W and Duan W: Management of
gestational trophoblastic neoplasia with 5-fluorouracil and
actinomycin D in northern China. J Reprod Med. 54:88–94.
2009.PubMed/NCBI
|
|
8
|
Tsukamoto N, Iwasaka T, Kashimura Y,
Uchino H, Kashimura M and Matsuyama T: Gestational trophoblastic
disease in women aged 50 or more. Gynecol Oncol. 20:53–61. 1985.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Soper JT: Surgical therapy for gestational
trophoblastic disease. J Reprod Med. 39:168–174. 1994.PubMed/NCBI
|
|
10
|
Tidy JA, Gillespie AM, Bright N, Radstone
CR, Coleman RE and Hancock BW: Gestational trophoblastic disease: a
study of mode of evacuation and subsequent need for treatment with
chemotherapy. Gynecol Oncol. 78:309–312. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kajii T and Ohama K: Androgenetic origin
of hydatidiform mole. Nature. 268:633–634. 1977. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Kim CH, Kim YH, Kim JW, et al: Triplet
pregnancy with partial hydatidiform mole coexisting with two
fetuses: a case report. J Obstet Gynaecol Res. 34:641–644. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Niemann I, Bolund L and Sunde L: Twin
pregnancies with diploid hydatidiform mole and co-existing normal
fetus may originate from one oocyte. Hum Reprod. 23:2031–2035.
2008. View Article : Google Scholar : PubMed/NCBI
|
