Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

  • Authors:
    • Takeshi Hori
    • Taketoshi Yasuda
    • Kayo Suzuki
    • Masahiko Kanamori
    • Tomoatsu Kimura
  • View Affiliations

  • Published online on: February 28, 2012     https://doi.org/10.3892/ol.2012.622
  • Pages: 1105-1108
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Skeletal metastases from carcinoid tumors are considered to be extremely rare. In this study, we present two cases of carcinoid tumors that metastasized to the bone. Furthermore, we review 50 published case reports and reveal the features of skeletal metastasis of carcinoid tumors. The first case involved a 59‑year-old man with a history of multiple metastases of a lung carcinoid tumor. The patient complained of back pain and numbness in the lower limbs. Magnetic resonance imaging revealed metastases in the thoracic spine. A spinal decompression was performed and the symptoms were resolved. The second case involved a 74-year-old man had been diagnosed with a lung carcinoid tumor 15 years previously and complained of left thigh pain. A radiograph showed osteolytic lesions in the shaft of the left femur. We repaired the femur using an intramedullary nail following curettage of the tumor. A radiograph of the femur revealed a callus on the pathological fracture. The patient was able to walk using a crutch 3 months after surgery. We reviewed 50 cases that described skeletal metastasis from carcinoid tumors. The average age of the patients was 54.9 years and 33 patients (66%) were male. The most common site of skeletal metastasis was the spine. We also investigated the survival rate of patients who developed skeletal metastasis from carcinoid tumors. The findings showed that survival of patients who developed osteolytic skeletal metastasis was worse than that of patients who developed osteosclerotic skeletal metastasis.
View Figures
View References

Related Articles

Journal Cover

May 2012
Volume 3 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hori T, Yasuda T, Suzuki K, Kanamori M and Kimura T: Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature. Oncol Lett 3: 1105-1108, 2012.
APA
Hori, T., Yasuda, T., Suzuki, K., Kanamori, M., & Kimura, T. (2012). Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature. Oncology Letters, 3, 1105-1108. https://doi.org/10.3892/ol.2012.622
MLA
Hori, T., Yasuda, T., Suzuki, K., Kanamori, M., Kimura, T."Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature". Oncology Letters 3.5 (2012): 1105-1108.
Chicago
Hori, T., Yasuda, T., Suzuki, K., Kanamori, M., Kimura, T."Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature". Oncology Letters 3, no. 5 (2012): 1105-1108. https://doi.org/10.3892/ol.2012.622