The pathobiological features of gastrointestinal cancers (Review)

Yang,Xue; Takano,Yasuo; Zheng,Hua-Chuan

doi:10.3892/ol.2012.628

The pathobiological features of gastrointestinal cancers (Review)

Authors:
- Xue Yang
- Yasuo Takano
- Hua-Chuan Zheng
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Affiliations: Department of Biochemistry and Molecular Biology and Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, P.R. China, Clinical Research Institute, Kanagawa Cancer Center, Yokohama 241-0815, Japan
Published online on: March 1, 2012 https://doi.org/10.3892/ol.2012.628
Pages: 961-969

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Abstract

Gastrointestinal adenocarcinoma (GIA) is a common malignant disease worldwide. Its tumorigenesis and progression is a multistage process with the involvement of a multifactorial etiology. Knowledge regarding altered expression of these genes during carcinogenesis may not only provide information about the molecular events during the initiation and progression of cancer, but may also result in the discovery of biological markers for the evaluation of cancer diagnosis and prognosis. In this review, we assessed molecular markers of pathogenesis, invasion, metastasis and prognosis, such as tumor suppressor and metastasis suppressor genes, and angiogenesis, cell adhesion, cell mobility, ER stress, mucin production, threonine protein kinase and REG family protein expression, by the establishment of tissue microarray (TMA) of GIA and immunohistochemistry (IHC) by intermittent microwave irradiation and in situ hybridization (ISH). Finally, we characterized the pathobiological features of Lauren's and WHO subtypes. It was found that the aberrant and cell‑specific expression of these molecules is important in the malignant transformation of gastrointestinal epithelium and subsequent progression. These molecules also underlie the histogenic mechanisms of gastric carcinoma according to Lauren's and WHO classification. The combination of TMA, IHC and ISH may be widely applied to screen for molecular markers in GIA.

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1	Kelley JR and Duggan JM: Gastric cancer epidemiology and risk factors. J Clin Epidemiol. 56:1–9. 2003. View Article : Google Scholar : PubMed/NCBI
2	American Cancer Society. Colorectal cancer facts and figures. 2005
3	Moch H, Schraml P, Bubendorf L, Mirlacher M, Kononen J, Gasser T, Mihatsch MJ, Kallioniemi OP and Sauter G: High-throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma. Am J Pathol. 154:981–986. 1999. View Article : Google Scholar : PubMed/NCBI
4	Kumada T, Tsuneyama K, Hatta H, Ishizawa S and Takano Y: Improved 1-h rapid immunostaining method using intermittent microwave irradiation: practicability based on 5 years application in Toyama Medical and Pharmaceutical University Hospital. Mod Pathol. 17:1141–1149. 2004.
5	Zheng H, Tsuneyama K, Cheng C, Takahashi H, Cui Z, Murai Y, Nomoto K and Takano Y: An immunohistochemical study of P53 and Ki-67 in gastrointestinal adenoma and adenocarcinoma using tissue microarray. Anticancer Res. 26:2353–2360. 2006.PubMed/NCBI
6	Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Tsuneyama K and Takano Y: Low expression of FHIT and PTEN correlates with malignancy of gastric carcinomas: tissue-array findings. Appl Immunohistochem Mol Morphol. 15:432–440. 2007. View Article : Google Scholar : PubMed/NCBI
7	Li XH, Zheng HC, Takahashi H, Masuda S, Yang XH and Takano Y: PTEN expression and mutation in colorectal carcinomas. Oncol Rep. 22:757–764. 2009.PubMed/NCBI
8	Xing YN, Yang X, Xu XY, Zheng Y, Xu HM, Takano Y and Zheng HC: The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression. Hum Pathol. 42:25–35. 2011. View Article : Google Scholar : PubMed/NCBI
9	Zheng HC, Xia P, Xu XY, Takahashi H and Takano Y: The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas. Hum Pathol. 42:424–433. 2011. View Article : Google Scholar : PubMed/NCBI
10	Zheng HC, Takahashi H, Li XH, Hara T, Masuda S, Guan YF and Takano Y: Downregulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas. Virchows Arch. 452:147–155. 2008. View Article : Google Scholar
11	Zheng HC, Wei ZL, Xu XY, Nie XC, Yang X, Takahashi H and Takano Y: Parafibromin expression is an independent prognostic factor for colorectal carcinomas. Hum Pathol. 8:1089–1102. 2011. View Article : Google Scholar : PubMed/NCBI
12	Lee JH, Park SR, Chay KO, Seo YW, Kook H, Ahn KY, Kim YJ and Kim KK: KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumour metastasis suppressor, and enhances metastasis of cancer. Cancer Res. 64:4235–4243. 2004. View Article : Google Scholar : PubMed/NCBI
13	Schoenfeld N, Bauer MK and Grimm S: The metastasis suppressor gene C33/CD82/KAI1 induces apoptosis through reactive oxygen intermediates. FASEB J. 18:158–160. 2004.PubMed/NCBI
14	Zheng H, Tsuneyama K, Cheng C, Takahashi H, Cui Z, Nomoto K, Murai Y and Takano Y: Expression of KAI1 and tenascin, and microvessel density are closely correlated with liver metastasis of gastrointestinal adenocarcinoma. J Clin Pathol. 60:50–56. 2007. View Article : Google Scholar : PubMed/NCBI
15	Maass N, Hojo T, Ueding M, Luttges J, Kloppel G, Jonat W and Nagasaki K: Expression of the tumor suppressor gene Maspin in human pancreatic cancers. Clin Cancer Res. 7:812–817. 2001.PubMed/NCBI
16	Sood AK, Fletcher MS, Gruman LM, Coffin JE, Jabbari S, Khalkhali-Ellis Z, Arbour N, Seftor EA and Hendrix MJ: The paradoxical expression of maspin in ovarian carcinoma. Clin Cancer Res. 8:2924–2932. 2002.PubMed/NCBI
17	Hirai K, Koizumi K, Haraguchi S, Hirata T, Mikami I, Fukushima M, Yamagishi S, Kawashima T, Okada D, Shimizu K and Kawamoto M: Prognostic significance of the tumor suppressor gene maspin in non-small cell lung cancer. Ann Thorac Surg. 79:248–253. 2005. View Article : Google Scholar : PubMed/NCBI
18	Ito Y, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Matsuura N, Kuma K and Miyauchi A: Maspin expression is directly associated with biological aggressiveness of thyroid carcinoma. Thyroid. 14:13–18. 2004. View Article : Google Scholar : PubMed/NCBI
19	Sugimoto S, Maass N, Takimoto Y, Sato K, Minei S, Zhang M, Hoshikawa Y, Junemann KP, Jonat W and Nagasaki K: Expression and regulation of tumor suppressor gene maspin in human bladder cancer. Cancer Lett. 203:209–215. 2004. View Article : Google Scholar : PubMed/NCBI
20	Yu M, Zheng H, Tsuneyama K, Takahashi H, Nomoto K, Xu H and Takano Y: Paradoxical expression of maspin in gastric carcinomas: correlation with carcinogenesis and progression. Hum Pathol. 38:1248–1255. 2007. View Article : Google Scholar : PubMed/NCBI
21	Zheng H, Tsuneyama K, Cheng C, Takahashi H, Cui Z, Murai Y, Nomoto K and Takano Y: Maspin expression was involved in colorectal adenoma-adenocarcinoma sequence and liver metastasis of tumors. Anticancer Res. 27:259–265. 2007.PubMed/NCBI
22	Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Niwa H, Tsuneyama K and Takano Y: Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma. Anticancer Res. 26:3579–3583. 2006.PubMed/NCBI
23	Zheng HC, Sun JM, Li XH, Yang XF, Zhang YC and Xin Y: Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma. Pathol Int. 53:659–666. 2003. View Article : Google Scholar : PubMed/NCBI
24	Zheng HC, Wang W, Xu XY, Xia P, Yu M, Sugiyama T and Takano Y: Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level. J Cancer Res Clin Oncol. 137:585–596. 2011. View Article : Google Scholar
25	Zheng HC, Takahashi H, Murai Y, Cui ZG, Nomoto K, Miwa S, Tsuneyama K and Takano Y: Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis. Br J Cancer. 95:1371–1378. 2006. View Article : Google Scholar : PubMed/NCBI
26	Li X, Zheng H, Hara T, Takahashi H, Masuda S, Wang Z, Yang X, Guan Y and Takano Y: Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas. Int J Oncol. 33:69–79. 2008.PubMed/NCBI
27	Zheng HC, Zheng YS, Li XH, Takahashi H, Hara T, Masuda S, Yang XH, Guan YF and Takano Y: Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma. Anticancer Res. 28:2225–2232. 2008.PubMed/NCBI
28	Takahashi H, Wang JP, Zheng HC, Masuda S and Takano Y: Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis. Histol Histopathol. 26:663–671. 2011.PubMed/NCBI
29	Zheng HC, Takahashi H, Li XH, Hara T, Masuda S, Guan YF and Takano Y: Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas. Hum Pathol. 39:1042–1049. 2008. View Article : Google Scholar : PubMed/NCBI
30	Zheng HC, Xu XY, Xia P, Yu M, Takahashi H and Takano Y: Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas. Hum Pathol. 41:1255–1264. 2010. View Article : Google Scholar : PubMed/NCBI
31	Zheng HC, Tsuneyama K, Takahashi H, Miwa S, Sugiyama T, Popivanova BK, Fujii C, Nomoto K, Mukaida N and Takano Y: Aberrant Pim-3 expression is involved in gastric adenoma adenocarcinoma sequence and cancer progression. J Cancer Res Clin Oncol. 134:481–488. 2008. View Article : Google Scholar : PubMed/NCBI
32	Li XH, Zheng HC, Wang ZG, Takahashi H, Yang XH, Guan YF and Takano Y: The clinicopathological and prognostic significance of MUC-1 expression in Japanese gastric carcinomas: an immunohistochemical study of tissue microarrays. Anticancer Res. 28:1061–1067. 2008.PubMed/NCBI
33	Zheng H, Takahashi H, Nakajima T, Murai Y, Cui Z, Nomoto K, Tsuneyama K and Takano Y: MUC6 down-regulation correlates with gastric carcinoma progression and a poor prognosis: an immunohistochemical study with tissue microarrays. J Cancer Res Clin Oncol. 132:817–823. 2006. View Article : Google Scholar : PubMed/NCBI
34	Zheng HC, Xu XY, Yu M, Takahashi H, Masuda S and Takano Y: The role of Reg IV gene and its encoding product in gastric carcinogenesis. Hum Pathol. 41:59–69. 2010. View Article : Google Scholar : PubMed/NCBI
35	Zheng HC, Sugawara A, Okamoto H, Takasawa S, Takahashi H, Masuda S and Takano Y: Expression profile of the REG gene family in colorectal carcinoma. J Histochem Cytochem. 59:106–115. 2011. View Article : Google Scholar : PubMed/NCBI
36	Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Miwa S, Tsuneyama K and Takano Y: Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray. J Clin Pathol. 60:273–277. 2007. View Article : Google Scholar : PubMed/NCBI
37	Zheng HC, Li XH, Hara T, Masuda S, Yang XH, Guan YF and Takano Y: Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas. Virchows Arch. 452:525–534. 2008. View Article : Google Scholar : PubMed/NCBI
38	Zheng HC, Zheng YS, Xia P, Xu XY, Xing YN, Takahashi H, Guan YF and Takano Y: The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes. Histol Histopathol. 25:445–452. 2010.PubMed/NCBI