Gastric carcinosarcoma: A case report and review of the literature

Cirocchi,Roberto; Trastulli,Stefano; Desiderio,Jacopo; Grassi,Veronica; Barillaro,Ivan; Santoro,Alberto; Boselli,Carlo; Avenia,Nicola; Noya,Giuseppe; De Sol,Angelo

doi:10.3892/ol.2012.699

Gastric carcinosarcoma: A case report and review of the literature

Authors:
- Roberto Cirocchi
- Stefano Trastulli
- Jacopo Desiderio
- Veronica Grassi
- Ivan Barillaro
- Alberto Santoro
- Carlo Boselli
- Nicola Avenia
- Giuseppe Noya
- Angelo De Sol
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Affiliations: Department of General Surgery, University of Perugia, St. Maria Hospital, Terni, Italy, Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy, Department of General and Oncologic Surgery, University of Perugia, Perugia, Italy, Endocrine Surgical Unit, Department of Surgical Sciences, Radiology and Dentistry, University of Perugia, Perugia, Italy
Published online on: April 27, 2012 https://doi.org/10.3892/ol.2012.699
Pages: 53-58

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Abstract

Carcinosarcoma of the stomach is a rare biphasic tumor that consists of both carcinomatous and sarcomatous components. The common carcinoma component is tubular or papillary adenocarcinoma and the mesenchymal sarcomatous components are variable but may include leiomyosarcoma, rhabdomyosarcoma and osteosarcoma. The aim of this study was to describe the characteristics of gastric carcinosarcoma and to present a review of the available literature. We report a case of carcinosarcoma in a 62-year-old female including the clinical and histopathological features of this tumor. Following ultrasound and computed tomography scans, laparotomy was performed, revealing a large mass, followed by radical surgery. Macroscopically, a polypoid tumor was observed. Microscopically, the tumor was composed of moderately differentiated adenocarcinoma and poorly differentiated sarcoma with a high mitotic index and necrotic areas. At present, the achievement of a definitive diagnosis is dependent on immunohistochemical staining and radical surgery. Thus, more effective diagnostic methods are required to improve patient survival.

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