The expression of KIT receptor dimers in gastrointestinal stromal tumors independent of c-kit mutation and SCF expression is associated with high-risk stratification

A UllrichJ SchlessingerSingnal transduction by receptors with tyrosine kinase activityCell61203212199010.1016/0092-8674(90)90801-K2158859

Y YardenWJ KuangT Yang-FengL CoussensS MunemitsuTJ DullHuman proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligandEMBO J63341335119872448137

Y YardenJA EscobedoWJ KuangTJ Yang-FengTO DanielPM TrembleStructure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptorsNature323226232198610.1038/323226a03020426

FH QiuHP RayY BrownPE BarkerS JhanwarFH RuddleP BesmerPrimary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminusEMBO J71003111119882456920

S BishayeeS MajunderJ KhireM DasLigand induced dimerization of the platelet-derived growth factor receptorJ Biol Chem264116991170519892545680

P Blume-JensenL Claesson-WelshA SiegbahnKM ZseboB WestermarkCH HeldinActivation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxisEMBO J10412141281991

L CoussensC Van BeverenD SmithStructural alteration of viral homologue of recap or proto-oncogene fms at carboxyl terminusNature320277280198610.1038/320277a02421165

AM TurnerLG BennettNL LinJ WypychTD BartleyRW HuntHL AtkinsKE LangleyV ParkerF MartinVC BroudyIdentification and characterization of a soluble form of the c-kit receptorBlood83214521521995

J WypychLG BennettMG SchwartzCL ClogstonHS LuVC BroudyTD BartleyVP ParkerKE LangleySoluble kit receptor in human serumBlood85667319957528574

VC BroudyNL LinDF SabathThe fifth immunoglobulin-like domain of the kit receptor is required for proteolytic cleavage from the cell surfaceCytokine15188195200110.1006/cyto.2001.090711563879

LC CantleyThe phosphoinositide 3-kinase pathwayScience29616551657200210.1126/science.296.5573.165512040186

AD ReithC EllisSD LymanDM AndersonDE WilliamsA BernsteinT PawsonSignal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinaseEMBO J102451245919911714377

PS CohenJP ChanM LipkunskayaJL BiedlerRC SeegerExpression of stem cell factor and c-kit in human neuroblastoma. The Children’s Cancer GroupBlood84346534721994

S HassanY KinoshitaC KawanamiK KishiY MatsushimaA OhashiY FunasakaA OkadaT MaekawaW He-YaoT ChibaExpression of proto-oncogene c-kit and its ligand stem cell factor (SCF) in gastric carcinoma cell linesDig Dis Sci43814199810.1023/A:10188514157049508539

SJ HinesC OrganMJ KornsteinGW KrystalCoexpression of the c-kit and stem cell factor genes in breast carcinomasCell Growth Differ676977919957545433

M InoueS KyoM FujitaT EnomotoG KondohCoexpression of the c-kit receptor and the stem cell factor in gynecological tumorsCancer Res543049305319947514496

GW KrystalSJ HinesCP OrganAutocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factorCancer Res5637037619968542594

T PietschU KyasU SteffensE YakisanMR HadamWD LudwigK ZseboK WelteEffects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth factorsBlood801199120619921381238

M ToyotaY HinodaA TakaokaY MakiguchiT TakahashiF ItohK ImaiA YachiExpression of c-kit and kit ligand in human colon carcinoma cellsTumour Biol14295302199310.1159/0002178427694350

N Théou-AntonS TaboneD Brouty-BoyéCo expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanismBr J Cancer9411801185200616570044

T NegriF BozziE ConcaOncogenic and ligand-dependent activation of KIT/PDGFRA in surgical samples of imatinib-treated gastrointestinal stromal tumours (GISTs)J Pathol217103112200910.1002/path.245018973210

T KoletsaI KostopoulosE CharalambousA splice variant of HER2 corresponding to Herstatin is expressed in the noncancerous breast and in breast carcinomasNeoplasia10687696200818592003

MC FranklinKD CareyFF VajdosInsights into ErbB signaling from the structure of the ErbB2-pertuzumab complexCancer Cell4317328200410.1016/S1535-6108(04)00083-215093539

CR ShawR PrasadGel electrophoresis of enzymes, a compilation of recipesBiochem Genet4297320197010.1007/BF004857804193186

CR ShawAL KoenStarch gel zone electrophoresis of enzymesChromatographic and Electrophoretic TechniquesI Smith2HeinemannLondon, UK3323591968

H HarrisDA HopkinsonHandbook of Enzyme Electrophoresis in Human GeneticsNorth-HollandAmsterdam1976

O GabrielLocating enzymes on gelsMethods in EnzymologySP ColowickNO Kaplan22AcademicNew York, NY578197110.1016/0076-6879(71)22042-5

O GabrielDM GerstenStaining for enzymatic activity after gel electrophoresisAnal Biochem203121199210.1016/0003-2697(92)90036-71381872