14‑kDa Phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation

Han,Su‑Xia; Wang,Li‑Juan; Zhao,Jing; Zhang,Ying; Li,Meng; Zhou,Xia; Wang,Jing; Zhu,Qing

doi:10.3892/ol.2012.802

October 2012 Volume 4 Issue 4

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October 2012 Volume 4 Issue 4

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Article

14‑kDa Phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation

Authors:
- Su‑Xia Han
- Li‑Juan Wang
- Jing Zhao
- Ying Zhang
- Meng Li
- Xia Zhou
- Jing Wang
- Qing Zhu
View Affiliations / Copyright

Affiliations: Department of Oncology, The First Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
Pages: 658-664
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Published online on: July 13, 2012

https://doi.org/10.3892/ol.2012.802
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Abstract

14‑kDa Phosphohistidine phosphatase (PHP14), the first histidine phosphatase protein identified in vertebrates, was recently revealed to play an essential role in lung cancer. The function of this gene in other tumors is unclear; however, in this study, we demonstrate that PHP14 is highly expressed in hepatocellular carcinoma (HCC) tissues and cell lines compared with adjacent non‑cancerous human liver tissues and cells (P<0.05). We used lentivirus‑mediated delivery of small interfering RNA (siRNA) to knockdown the expression of PHP14 in an HCC cell line and investigate the effects of PHP14 on cell growth in vitro. Cell proliferation was inhibited and cell apoptosis was significantly increased. PHP14‑siRNA affected the cell cycle and promoted G1→S phase transition in HCC cells. These results demonstrate that the knockdown of PHP14 expression by lentivirus‑delivered siRNA may be a useful therapeutic approach for the treatment of HCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

14‑kDa Phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation

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