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Article

Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C

  • Authors:
    • Shu-Pei Ma
    • Mei Lin
    • Hai-Ning Liu
    • Jian-Xian Yu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Qingdao Municipal Hospital, Qingdao, P.R. China, Department of Pathology, Medical College of Qingdao University, Qingdao, P.R. China, Department of Reproductive Medicine, The Affiliated Hospital of Qingdao University Medical College, Qingdao, P.R. China , Department of Pathology, Qingdao Municipal Hospital, Qingdao, P.R. China
  • Pages: 695-700
    |
    Published online on: July 23, 2012
       https://doi.org/10.3892/ol.2012.817
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Abstract

We aimed to investigate the correlations between lymphangiogenesis, cyclooxygenase (COX)-2 and vascular endothelial growth factor-C (VEGF-C) in non-Hodgkin's lymphoma (NHL) and their associations with the clinical parameters of patients. A total of 75 patients diagnosed with NHL were enrolled in this study. Of the 75 patients, 14 (18.7%) had low-grade and 61 (81.3%) had aggressive lymphoma. We examined the immunohistochemical expression of COX-2 and VEGF-C and estimated lymphangiogenesis by counting lymphatic vessels expressing lymph vessel endothelial hyaluronan receptor-1 (LYVE-1). Our results showed that lymphatic vessel density (LVD) was positive in 59.0% of the cases with aggressive morphology, while the LVD positive rate of indolent lymphoma was only 28.6% (P=0.039). Both COX-2 and VEGF-C were correlated with lymphangiogenesis (P=0.030 and 0.000, respectively). The expression levels of COX-2 and VEGF-C were significantly correlated (P=0.015). LVD, COX-2 and VEGF-C were not correlated with the gender, age, lactate dehydrogenase (LDH) levels, β2 microglobulin (β2M) levels, extranodal involvement, disease stage, B symptoms or international prognostic index of the patients. In conclusion, lymphangiogenesis was correlated with aggressive histology in NHL. COX-2 and VEGF-C are inducers of lymphangiogenesis and their expression levels were correlated in NHL.
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Copy and paste a formatted citation
Spandidos Publications style
Ma S, Lin M, Liu H and Yu J: Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C. Oncol Lett 4: 695-700, 2012.
APA
Ma, S., Lin, M., Liu, H., & Yu, J. (2012). Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C. Oncology Letters, 4, 695-700. https://doi.org/10.3892/ol.2012.817
MLA
Ma, S., Lin, M., Liu, H., Yu, J."Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C". Oncology Letters 4.4 (2012): 695-700.
Chicago
Ma, S., Lin, M., Liu, H., Yu, J."Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C". Oncology Letters 4, no. 4 (2012): 695-700. https://doi.org/10.3892/ol.2012.817
Copy and paste a formatted citation
x
Spandidos Publications style
Ma S, Lin M, Liu H and Yu J: Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C. Oncol Lett 4: 695-700, 2012.
APA
Ma, S., Lin, M., Liu, H., & Yu, J. (2012). Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C. Oncology Letters, 4, 695-700. https://doi.org/10.3892/ol.2012.817
MLA
Ma, S., Lin, M., Liu, H., Yu, J."Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C". Oncology Letters 4.4 (2012): 695-700.
Chicago
Ma, S., Lin, M., Liu, H., Yu, J."Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C". Oncology Letters 4, no. 4 (2012): 695-700. https://doi.org/10.3892/ol.2012.817
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