Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma
- Authors:
- Amalia Birau
- Raluca Amalia Ceausu
- Anca Maria Cimpean
- Pusa Gaje
- Marius Raica
- Teodora Olariu
View Affiliations
Affiliations: Department of Intensive Care, ‘Vasile Goldis’ Western University of Arad, Arad, Arad 310396, Romania, Department of Histology, ‘Victor Babeș’ University of Medicine and Pharmacy, Angiogenesis Research Center, Timisoara, Timis 300041, Romania
- Published online on: September 5, 2012 https://doi.org/10.3892/ol.2012.893
-
Pages:
1183-1186
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Abstract
Despite advances in treatment, the prognosis for lung cancer patients remains poor. Angiogenesis appears to be a promising target for lung cancer therapy; however, the clinical significance of vascular changes are not completely understood. The aim of this study was to evaluate the types and morphology of blood vessels in various lung carcinomas. Using double immunostaining, we investigated 39 biopsies from patients admitted with various histological types of lung carcinoma. Tumor blood vessels were quantified separately for CD34/smooth muscle actin and described as either immature, intermediate or mature. Double immunostaining evaluation of the type of blood vessels in lung carcinomas revealed a marked heterogeneity. The immature and intermediate type of vessels were more common in adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs) of the lung. Small cell lung carcinomas revealed a significant correlation between pathological and immature types of blood vessels. Therefore, quantifying the types of tumor vessels in lung carcinomas may be an important element to improve the results of anti‑vascular therapy.
View References
|
1.
|
A JemalR SiegelE WardY HaoJ XuT MurrayMJ
ThunCancer statistics, 2008CA Cancer J
Clin587196200810.3322/CA.2007.0010
|
|
2.
|
DE deMelloLM ReidEmbryonic and early fetal
development of human lung vasculature and its functional
implicationsPediatr Dev
Pathol3439449200010.1007/s10024001009010890928
|
|
3.
|
MC PareraM van DoorenM van KempenR de
KrijgerF GrosveldD TibboelR RottierDistal angiogenesis: a new
concept for lung vascular morphogenesisAm J Physiol Lung Cell Mol
Physiol288L141L149200510.1152/ajplung.00148.200415377499
|
|
4.
|
J FolkmanWhat is the evidence that tumours
are angiogenesis dependent?J Natl Cancer
Inst8246199010.1093/jnci/82.1.41688381
|
|
5.
|
JA NagySH ChangSC ShihAM DvorakHF
DvorakHeterogeneity of the tumor vasculatureSemin Thromb
Hemost36321331201010.1055/s-0030-125345420490982
|
|
6.
|
P CarmelietRK JainMolecular mechanisms and
clinical applications of
angiogenesisNature473298307201110.1038/nature1014421593862
|
|
7.
|
A EberhardS KahlertV GoedeB HemmerleinKH
PlateHG AugustinHeterogeneity of angiogenesis and blood vessel
maturation in human tumors: implications for antiangiogenic tumor
therapiesCancer Res60138813932000
|
|
8.
|
E PassalidouM TrivellaN SinghM FergusonJ
HuA CesarioP GranoneAG NicholsonP GoldstrawC RatcliffeVascular
phenotype in angiogenic and non-angiogenic lung non-small cell
carcinomasBr J Cancer86244249200210.1038/sj.bjc.660001511870514
|
|
9.
|
J GuoK HigashiY UedaM OguchiT TakegamiH
TogaT SakumaH YokotaS KatsudaH TonamiI YamamotoMicrovessel density:
correlation with 18F-FDG uptake and prognostic impact in lung
adenocarcinomasJ Nucl Med47419425200616513610
|
|
10.
|
S KakolyrisA GiatromanolakiM KoukourakisL
KaklamanisCH KouroussisV BozionelouV GeorgouliasKC GatterAL
HarrisAssessement of vascular maturation in lung and breast
carcinomas using a novel basement membrane component,
LH39Anticancer Res21431143162001
|
|
11.
|
CF MountainRevisions in the International
System for Staging Lung
CancerChest11117101717199710.1378/chest.111.6.17109187198
|
|
12.
|
A SandlerR GrayMC PerryJ BrahmerJH
SchillerA DowlatiR LilenbaumDH JohnsonPaclitaxel-carboplatin alone
or with bevacizumab for non-small-cell lung cancerN Engl J
Med35525422550200610.1056/NEJMoa06188417167137
|
|
13.
|
MS GeeWN ProcopioS MakonnenMD FeldmanNM
YeildingWM LeeTumor vessel development and maturation impose limits
on the effectiveness of anti-vascular therapyAm J
Pathol162183193200310.1016/S0002-9440(10)63809-6
|
|
14.
|
R MaedaG IshiiM ItoT HishidaJ YoshidaM
NishimuraH HagaK NagaiA OchiaiNumber of circulating endothelial
progenitor cells and intratumoral microvessel density in non-small
cell lung cancer patients: differences in angiogenic status between
adenocarcinoma histologic subtypesJ Thorac
Oncol7503511201210.1097/JTO.0b013e318241780e
|
|
15.
|
K DagnonD HeudesJF BernaudinP
CallardComputerized morphometric analysis of microvasculature in
non-small cell lung carcinomaMicrovasc
Res75112118200810.1016/j.mvr.2007.04.00417560614
|
|
16.
|
P CarmelietRK JainAngiogenesis in cancer
and other diseasesNature407249257200010.1038/3502522011001068
|
|
17.
|
YY ZhaoC XueW JiangHY ZhaoY HuangK
FeenstraJH ResauCN QianL ZhangPredictive value of intratumoral
microvascular density in patients with advanced non-small cell lung
cancer receiving chemotherapy plus bevacizumabJ Thorac
Oncol77175201210.1097/JTO.0b013e31823085f422011670
|
|
18.
|
C GridelliP MaioneA RossiF De
MarinisTreatment of non-small cell lung cancer: current indications
and future
developmentsOncologist1211831193200710.1634/theoncologist.12-10-118317962612
|
|
19.
|
AM JubbA CesarioM FergusonMT CongedoKC
GatterF LococoA MulèF PezzellaVascular phenotypes in primary
non-small cell lung carcinomas and matched brain metastasesBr J
Cancer718771881201110.1038/bjc.2011.14721540863
|
