Recurrent prognostic factors and expression of GLUT‑1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

Fang,Jin; Bao,Yang-Yang; Zhou,Shui-Hong; Luo,Xing-Mei; Yao,Hong‑Tian; He,Jian-Feng; Wang,Qin-Ying

doi:10.3892/ol.2012.895

Recurrent prognostic factors and expression of GLUT‑1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma

Authors:
- Jin Fang
- Yang-Yang Bao
- Shui-Hong Zhou
- Xing-Mei Luo
- Hong‑Tian Yao
- Jian-Feng He
- Qin-Ying Wang
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Affiliations: Department of Otolaryngology, The Second Hospital of Jiaxing City, Jiaxing 314000, P.R. China, Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
Published online on: September 5, 2012 https://doi.org/10.3892/ol.2012.895
Pages: 1234-1240

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Abstract

The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.

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