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Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice

  • Authors:
    • Cheng-Hua Zhou
    • Ya-Ya Wan
    • Xiang-Hua Chu
    • Zheng Song
    • Shu-Hua Xing
    • Yu-Qing Wu
    • Xiao-Xing Yin

  • View Affiliations

  • Published online on: September 21, 2012     https://doi.org/10.3892/ol.2012.932
  • Pages: 1259-1263
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Abstract

Urotensin II (UII), a somatostatin-like cyclic peptide, was originally isolated from the fish urophysis. Our previous study showed that UII stimulates the proliferation of A549 lung adenocarcinoma cells and promotes tumor growth in a nude mouse xenograft model, suggesting that UII may contribute to the pathogenesis of lung adenocarcinoma. In this study, the underlying mechanism for UII to promote lung adenocarcinoma growth was explored by observing the effect of UII on the tumor inflammatory microenvironment in tumor-bearing nude mice. Immunohistochemical analysis showed that UII promoted the infiltration of CD68+ tumor-associated macrophages (TAMs) in the tumor microenvironment. Enzyme-linked immunosorbent assay (ELISA) demonstrated that UII promoted the release of interleukin‑6 (IL‑6), tumor necrosis factor-α (TNF‑α) and matrix metalloproteinase‑9 (MMP‑9). Western blot analysis showed that UII promoted the activation of nuclear factor‑κB (NF‑κB). These findings suggest that the enhanced levels of IL‑6, TNF‑α and MMP‑9 in the tumor microenvironment, which likely resulted from increased activation of NF‑κB induced by UII, may be one of the important mechanisms by which UII promotes lung adenocarcinoma growth. These findings imply that antagonists of UII or urotensin II-receptor (UT‑R) have potential for the prevention and treatment of lung adenocarcinoma.
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December 2012
Volume 4 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Impact Factor: 2.5
  • Ranked Oncology
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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Zhou C, Wan Y, Chu X, Song Z, Xing S, Wu Y and Yin X: Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice. Oncol Lett 4: 1259-1263, 2012.
APA
Zhou, C., Wan, Y., Chu, X., Song, Z., Xing, S., Wu, Y., & Yin, X. (2012). Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice. Oncology Letters, 4, 1259-1263. https://doi.org/10.3892/ol.2012.932
MLA
Zhou, C., Wan, Y., Chu, X., Song, Z., Xing, S., Wu, Y., Yin, X."Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice". Oncology Letters 4.6 (2012): 1259-1263.
Chicago
Zhou, C., Wan, Y., Chu, X., Song, Z., Xing, S., Wu, Y., Yin, X."Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice". Oncology Letters 4, no. 6 (2012): 1259-1263. https://doi.org/10.3892/ol.2012.932