Expression and significance of hypoxia-inducible factor‑1α and glucose transporter-1 in laryngeal carcinoma Corrigendum in /ol/6/1/287

Wu,Xiao-Hong; Chen,Su-Ping; Mao,Jian-Ying; Ji,Xue‑Xian; Yao,Hong-Tian; Zhou,Shui-Hong

doi:10.3892/ol.2012.941

Expression and significance of hypoxia-inducible factor‑1α and glucose transporter-1 in laryngeal carcinoma

Corrigendum in: /ol/6/1/287

Authors:
- Xiao-Hong Wu
- Su-Ping Chen
- Jian-Ying Mao
- Xue‑Xian Ji
- Hong-Tian Yao
- Shui-Hong Zhou
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Affiliations: Department of Otolaryngology, The People's Hospital of Deqing County, Zhejiang (The Cooperative Hospital of The First Affiliated Hospital, College of Medicine, Zhejiang University), Deqing City, P.R. China, Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P.R. China, Department of Pathology, The People’s Hospital of Deqing County, Zhejiang (The Cooperative Hospital of The First Affiliated Hospital, College of Medicine, Zhejiang University), Deqing City, P.R. China
Published online on: September 26, 2012 https://doi.org/10.3892/ol.2012.941
Pages: 261-266

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Abstract

Malignant cells show increased glucose uptake in vitro and in vivo. This process is considered to be mediated by glucose transporters (GLUTs). Hypoxia-inducible factor-1α (HIF-1α) may upregulate GLUT-1 expression. Little is known about the correlation between HIF-1α and GLUT-1 expression in laryngeal carcinoma. The current study investigated this correlation immunohistochemically, according to various clinical and pathological features, in 49 paraffin‑embedded archival tissue blocks from patients with laryngeal squamous cell carcinoma. HIF-1α and GLUT-1 expression was detected in 63.3 (31/49) and 55.1% (27/49) of the tumour samples, respectively. HIF-1α expression was significantly correlated with lymph node classification (P=0.018), recurrence (P=0.02) and metastasis (P=0.031). GLUT-1A expression was significantly associated with recurrence (P=0.02) and metastasis (P=0.01). Univariate analyses revealed that HIF-1α (χ2=8.2; P=0.004) and GLUT-1 expression (χ2=9.0; P=0.003) were significantly associated with a poorer survival rate. In a multivariate analysis, GLUT-1 expression (P=0.006) was a significant predictor of poor survival rate, as well as the primary tumour site, lymph node invasion and distant metastasis. Based on Spearman's analysis, GLUT-1 expression and phosphatidylinositol 3-kinase (PI3K) expression were significantly correlated (r=0.504; P=0.000). This is the first study to demonstrate a significant correlation between GLUT-1 and HIF-1α expression in laryngeal carcinoma and to show increased GLUT-1 expression as an independent survival rate predictor. These results suggest that GLUT-1 is a potential new therapeutic target for laryngeal carcinoma.

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