Expression of cyclin E in stage III colorectal carcinoma

  • Authors:
    • Lea Rath-Wolfson
    • Michael Bergman
    • Yaacov Ori
    • Alex Goldman
    • Edward Ram
    • Rumelia Koren
    • Hertzel Salman
  • View Affiliations

  • Published online on: October 5, 2012     https://doi.org/10.3892/ol.2012.955
  • Pages: 145-148
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Abstract

Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. The expression of cyclin E was evaluated in 49 patients. Using a multivariate analysis, the expression of cyclin E in the tumor at diagnosis was compared with various clinicopathological variables, including age, gender, tumor site, tumor size, tumor differentiation and lymph node involvement. There were more node-positive cases in the cyclin E-negative group than in the cyclin E-positive group (P=0.003). However, there was no correlation between the degree of cyclin E expression and the clinical data. In conclusion, our data suggest that overexpression of cyclin E does not predict the clinical outcome in colorectal cancer stage III. Negative cyclin E staining may be associated with lymph node involvement.
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January 2013
Volume 5 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Rath-Wolfson L, Bergman M, Ori Y, Goldman A, Ram E, Koren R and Salman H: Expression of cyclin E in stage III colorectal carcinoma. Oncol Lett 5: 145-148, 2013.
APA
Rath-Wolfson, L., Bergman, M., Ori, Y., Goldman, A., Ram, E., Koren, R., & Salman, H. (2013). Expression of cyclin E in stage III colorectal carcinoma. Oncology Letters, 5, 145-148. https://doi.org/10.3892/ol.2012.955
MLA
Rath-Wolfson, L., Bergman, M., Ori, Y., Goldman, A., Ram, E., Koren, R., Salman, H."Expression of cyclin E in stage III colorectal carcinoma". Oncology Letters 5.1 (2013): 145-148.
Chicago
Rath-Wolfson, L., Bergman, M., Ori, Y., Goldman, A., Ram, E., Koren, R., Salman, H."Expression of cyclin E in stage III colorectal carcinoma". Oncology Letters 5, no. 1 (2013): 145-148. https://doi.org/10.3892/ol.2012.955