Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

  • Authors:
    • Saniya Nissar
    • Tufail Ahmad Lone
    • Mujeeb Zafar Banday
    • Roohi Rasool
    • Nissar A. Chowdri
    • Fazl Q. Parray
    • Safiya Abdullah
    • Aga Syed Sameer
  • View Affiliations

  • Published online on: January 3, 2013     https://doi.org/10.3892/ol.2013.1104
  • Pages: 959-963
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Abstract

The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no direct significant association between the XRCC1 genotypes and CRC; however, the Arg/Gln genotype was associated with an elevated risk of CRC (OR>1.47) and the Gln/Gln variant genotype was associated with an increased risk of CRC in various clinicopathological parameters. This study suggests that the XRCC1 polymorphism is associated with an increased risk of CRC.
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March 2013
Volume 5 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Nissar S, Lone TA, Banday MZ, Rasool R, Chowdri NA, Parray FQ, Abdullah S and Sameer AS: Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study. Oncol Lett 5: 959-963, 2013.
APA
Nissar, S., Lone, T.A., Banday, M.Z., Rasool, R., Chowdri, N.A., Parray, F.Q. ... Sameer, A.S. (2013). Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study. Oncology Letters, 5, 959-963. https://doi.org/10.3892/ol.2013.1104
MLA
Nissar, S., Lone, T. A., Banday, M. Z., Rasool, R., Chowdri, N. A., Parray, F. Q., Abdullah, S., Sameer, A. S."Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study". Oncology Letters 5.3 (2013): 959-963.
Chicago
Nissar, S., Lone, T. A., Banday, M. Z., Rasool, R., Chowdri, N. A., Parray, F. Q., Abdullah, S., Sameer, A. S."Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study". Oncology Letters 5, no. 3 (2013): 959-963. https://doi.org/10.3892/ol.2013.1104