Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy

  • Authors:
    • Kayoko Kibata
    • Takeshi Tamaki
    • Noriko Inagaki
    • Makoto Ogata
    • Toshiki Shimizu
    • Shosaku Nomura
  • View Affiliations

  • Published online on: February 5, 2013     https://doi.org/10.3892/ol.2013.1178
  • Pages: 1123-1128
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Abstract

Docetaxel is a well-known causative agent of nail alterations. The aim of this study was to reveal the impact of nail alterations associated with low-dose metronomic (LDM) docetaxel chemotherapy on the survival of non-small cell lung cancer (NSCLC) patients. Clinical information, survival data and nail alterations in patients treated with LDM docetaxel chemotherapy (docetaxel 15 mg/m2 per week) were retrospectively reviewed. Forty-nine patients were included in this study. Various nail alterations were observed in 17 of the 49 patients (34.7%). Onycholysis and subungual hyperkeratosis were observed in 22.4% and 10.2% of patients, respectively. The number of docetaxel administration cycles was correlated with the incidence and severity of nail alterations. Univariate and multivariate analysis clearly demonstrated that the occurrence of nail alterations was an independent favorable prognostic factor for overall survival. Nail alterations associated with treatment may act as a surrogate marker for the efficacy of low‑dose metronomic docetaxel chemotherapy.
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April 2013
Volume 5 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kibata K, Tamaki T, Inagaki N, Ogata M, Shimizu T and Nomura S: Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy. Oncol Lett 5: 1123-1128, 2013.
APA
Kibata, K., Tamaki, T., Inagaki, N., Ogata, M., Shimizu, T., & Nomura, S. (2013). Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy. Oncology Letters, 5, 1123-1128. https://doi.org/10.3892/ol.2013.1178
MLA
Kibata, K., Tamaki, T., Inagaki, N., Ogata, M., Shimizu, T., Nomura, S."Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy". Oncology Letters 5.4 (2013): 1123-1128.
Chicago
Kibata, K., Tamaki, T., Inagaki, N., Ogata, M., Shimizu, T., Nomura, S."Nail alterations as a surrogate marker for the efficacy of low-dose metronomic chemotherapy". Oncology Letters 5, no. 4 (2013): 1123-1128. https://doi.org/10.3892/ol.2013.1178