HPV genotypes in paraffin sections of non-cervical squamous cell carcinoma in Qingdao of China

Gao,Zhi  Di; Pan,Qi; Lv,Hong; Sun,Yang; Ma,Xiaoye; Qin,Zuorong; Sun,Yu  Ping

doi:10.3892/ol.2013.1181

HPV genotypes in paraffin sections of non-cervical squamous cell carcinoma in Qingdao of China

Authors:
- Zhi Di Gao
- Qi Pan
- Hong Lv
- Yang Sun
- Xiaoye Ma
- Zuorong Qin
- Yu Ping Sun
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Affiliations: Institute of Medicine, Shandong University, Jinan 250012, P.R. China, Department of General Surgery, Qingdao Hiser Medical Group, Qingdao 266033, P.R. China, Department of Pathology, Qingdao Hiser Medical Group, Qingdao 266033, P.R. China, Department of Otorhinolaryngology, Qingdao Hiser Medical Group, Qingdao 266033, P.R. China, Division of Oncology, Qingdao Hiser Medical Group, Qingdao 266033, P.R. China
Published online on: February 6, 2013 https://doi.org/10.3892/ol.2013.1181
Pages: 1219-1222

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Abstract

Human papillomaviruses (HPVs) are the cause of cervical cancer and possibly a subset of squamous cell carcinomas (SCCs) in other sites. However, the prevalence and distribution of HPV subtypes remain unclear. In the present study, we collected and analyzed 511 paraffin sections of non‑cervical SCC from patients in Qingdao, China, for the presence of HPV using polymerase chain reaction (PCR). We identified that 55.77% (285/511) of the samples were positive for HPV infection. There was a significant association between HPV type and the different sites of SCC. An association between HPV-positive cases and tobacco, alcohol, age and tumor differentiation was demonstrated. The information provided by this study may be important for further investigation into the association between HPV and SCC. High-risk HPV subtypes were associated with the malignant degree of SCC. This study provided a theoretical basis for the preventative treatment of non-cervical SCC using HPV vaccines.

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