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Article

Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer

  • Authors:
    • Faruk Tas
    • Fatma Sen
    • Nese Guney
    • Serkan Keskin
    • Hakan Camlica
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul 34390, Turkey
  • Pages: 1699-1703
    |
    Published online on: February 21, 2013
       https://doi.org/10.3892/ol.2013.1205
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Abstract

The synergistic effects of new generation chemotherapeutics when combined with cisplatin have encouraged the development of new triplet combination regimens in the treatment of advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the feasibility of triplet chemotherapy using weekly cisplatin-gemcitabine-docetaxel (CGD) for patients with chemotherapy-naive NSCLC. Twenty‑seven patients with stage IIIB/IV disease and performance status of 0 to 2 were included in this prospective trial. A combination of gemcitabine 750 mg/m2, cisplatin 25 mg/m2 and docetaxel 25 mg/m2 was administered on days 1, 8 and 15, with cycles repeated every 3 weeks. Leucopenia and/or neutropenia and to a lesser extent thrombocytopenia were the main dose-limiting toxicities. Grade III-IV neutropenia and thrombocytopenia occurred in 26 and 7% of the patients, respectively. Only one patient developed febrile neutropenia. Dose reductions were required in 26% of patients, delays in 44% of patients and early treatment discontinuation in 15% of patients. The overall response rate was 52% and all of them experienced a partial response. The median progression-free (PFS) and overall survival (OS) times were 6 and 13 months, respectively. The one-year survival rate was 46%. In conclusion, weekly administration of CGD is an active first-line therapy with acceptable toxicity in advanced NSCLC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Tas F, Sen F, Guney N, Keskin S and Camlica H: Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer. Oncol Lett 5: 1699-1703, 2013.
APA
Tas, F., Sen, F., Guney, N., Keskin, S., & Camlica, H. (2013). Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer. Oncology Letters, 5, 1699-1703. https://doi.org/10.3892/ol.2013.1205
MLA
Tas, F., Sen, F., Guney, N., Keskin, S., Camlica, H."Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer". Oncology Letters 5.5 (2013): 1699-1703.
Chicago
Tas, F., Sen, F., Guney, N., Keskin, S., Camlica, H."Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer". Oncology Letters 5, no. 5 (2013): 1699-1703. https://doi.org/10.3892/ol.2013.1205
Copy and paste a formatted citation
x
Spandidos Publications style
Tas F, Sen F, Guney N, Keskin S and Camlica H: Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer. Oncol Lett 5: 1699-1703, 2013.
APA
Tas, F., Sen, F., Guney, N., Keskin, S., & Camlica, H. (2013). Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer. Oncology Letters, 5, 1699-1703. https://doi.org/10.3892/ol.2013.1205
MLA
Tas, F., Sen, F., Guney, N., Keskin, S., Camlica, H."Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer". Oncology Letters 5.5 (2013): 1699-1703.
Chicago
Tas, F., Sen, F., Guney, N., Keskin, S., Camlica, H."Triplet chemotherapy combination with cisplatin, gemcitabine and docetaxel in patients with chemotherapy‑naive advanced non-small cell lung cancer". Oncology Letters 5, no. 5 (2013): 1699-1703. https://doi.org/10.3892/ol.2013.1205
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