Metastasis to the colon from lung cancer presenting with severe hyponatremia and dyspnea in a young male: A case report and review of the literature

Pezzuto,Aldo; Mariotta,Salvatore; Fioretti,Federica; Uccini,Stefania

doi:10.3892/ol.2013.1208

May 2013 Volume 5 Issue 5

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May 2013 Volume 5 Issue 5

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Case Report

Metastasis to the colon from lung cancer presenting with severe hyponatremia and dyspnea in a young male: A case report and review of the literature

Authors:
- Aldo Pezzuto
- Salvatore Mariotta
- Federica Fioretti
- Stefania Uccini
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Affiliations: Cardiopulmonary Department, Sant'Andrea Hospital, Sapienza University, Rome I-00189, Italy, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University, Rome I-00189, Italy, Department of Pathology, Sant'Andrea Hospital, Sapienza University, Rome I-00189, Italy
Pages: 1477-1480
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Published online on: February 22, 2013

https://doi.org/10.3892/ol.2013.1208
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Abstract

This study aimed to present the atypical clinical presentation and management of a metastatic lung cancer that had spread to an atypical location. Lung cancer is the most common cause of cancer-related mortality worldwide. The brain, liver, adrenal glands and bone are the most common sites of metastatic disease in patients with lung cancer. The reported incidence of symptomatic gastrointestinal metastases is 0.2-0.5%. Early diagnosis should be based on the observation of clinical symptoms and computed tomography (CT) imaging. In the present study, we describe the case of a 43-year-old male with a primary adenocarcinoma of the lung located in the lower right lobe. Following diagnosis, the patient underwent five lines of chemotherapy with a significant tumor reduction. Two years later, a mass located in the sigmoid colon was detected in the patient following a PET/CT scan. The clinical presentation was unusual with vomiting, headache, dyspnea and laboratory hyponatremia. A rare form of metastatic ulcerating adenocarcinoma was identified with colonoscopy, which was confirmed by immunohistochemical findings. A surgical approach was not performed due to the worsening condition of the patient. The patient demonstrated severe anemia and blood hypoxia, and one month later, the patient succumbed to disease. The metastasis may suggest an increase in tumor aggressiveness.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Metastasis to the colon from lung cancer presenting with severe hyponatremia and dyspnea in a young male: A case report and review of the literature

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Abstract

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