Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May 2013 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2013 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature

  • Authors:
    • Qiuyi Xu
    • Nong Xu
    • Weijia Fang
    • Peng Zhao
    • Chenyu Mao
    • Yulong Zheng
    • Haibo Mou
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003 P.R. China
  • Pages: 1601-1604
    |
    Published online on: March 6, 2013
       https://doi.org/10.3892/ol.2013.1232
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Primary Fallopian tube carcinoma (PFTC) is a rare but highly aggressive disease. Currently, treatments are similar to those used in epithelial ovarian carcinoma (EOC), however, there are distinct differences between the two diseases. PFTC tends to recur in the retroperitoneal nodes and distant sites more often than EOC. Limited literature with regard to effective agents in platinum-resistant and -refractory (Pt-R) disease exists, particularly after two lines of consecutive treatment. In this case report, a 47-year-old female with PFTC exhibited recurrence in the liver after postoperative chemotherapy. The patient received paclitaxel and cisplatin combination as first‑line chemotherapy and topotecan as a second-line treatment, which is considered platinum-refractory. After the second‑line treatment failed, this patient received a gemcitabine plus cisplatin combination as third-line chemotherapy for a total of 6 cycles. The liver metastases regressed rapidly and completely. The patient's progression-free survival (PFS) was 10 months and overall survival (OS) was 45 months. In conclusion, gemcitabine and cisplatin combination is an effective regimen for refractory PFTC even after the failure of two previous lines of consecutive chemotherapy and this warrants further independent investigation.
View Figures
View References

1 

Riska A, Leminen A and Pukkala E: Sociodemographic determinants of incidence of primary fallopian tube carcinoma, Finland 1953–97. Int J Cancer. 104:643–645. 2003.PubMed/NCBI

2 

Markman M, Webster K, Zanotti K, Kulp B, Peterson G and Belinson J: Phase 2 trial of single-agent gemcitabine in platinum-paclitaxel refractory ovarian cancer. Gynecol Oncol. 90:593–596. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Lorusso D, Di Stefano A, Fanfani F and Scambia G: Role of gemcitabine in ovarian cancer treatment. Ann Oncol. 17(Suppl 5): v188–v194. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Stewart SL, Wike JM, Foster SL and Michaud F: The incidence of primary fallopian tube cancer in the United States. Gynecol Oncol. 107:392–397. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Ajithkumar TV, Minimole AL, John MM and Ashokkumar OS: Primary fallopian tube carcinoma. Obstet Gynecol Surv. 60:247–252. 2005. View Article : Google Scholar

6 

Hefler LA, Rosen AC, Graf AH, et al: The clinical value of serum concentrations of cancer antigen 125 in patients with primary fallopian tube carcinoma: a multicenter study. Cancer. 89:1555–1560. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Wethington SL, Herzog TJ, Seshan VE, et al: Improved survival for fallopian tube cancer: a comparison of clinical characteristics and outcome for primary fallopian tube and ovarian cancer. Cancer. 113:3298–3306. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Rosen AC, Ausch C, Hafner E, et al: A 15-year overview of management and prognosis in primary fallopian tube carcinoma. Austrian Cooperative Study Group for Fallopian Tube Carcinoma. Eur J Cancer. 34:1725–1729. 1998.PubMed/NCBI

9 

Riska A and Leminen A: Updating on primary fallopian tube carcinoma. Acta Obstet Gynecol Scand. 86:1419–1426. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Papadimitriou CA, Peitsidis P, Bozas G, et al: Paclitaxel- and platinum-based postoperative chemotherapy for primary fallopian tube carcinoma: a single institution experience. Oncology. 75:42–48. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Gadducci A, Landoni F, Sartori E, et al: Analysis of treatment failures and survival of patients with fallopian tube carcinoma: a cooperation task force (CTF) study. Gynecol Oncol. 81:150–159. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Pectasides D, Pectasides E, Papaxoinis G, et al: Primary fallopian tube carcinoma: results of a retrospective analysis of 64 patients. Gynecol Oncol. 115:97–101. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Baekelandt M, Jorunn Nesbakken A, Kristensen GB, Tropé CG and Abeler VM: Carcinoma of the fallopian tube. Cancer. 89:2076–2084. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Tresukosol D, Kudelka AP, Edwards CL, Fromm GL, Mante R and Kavanagh JJ: Primary fallopian tube adenocarcinoma: clinical complete response after salvage treatment with high-dose paclitaxel. Gynecol Oncol. 58:258–261. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Dunton CJ and Neufeld J: Complete response to topotecan of recurrent fallopian tube carcinoma. Gynecol Oncol. 76:128–129. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Matsuo K, Lin YG, Roman LD and Sood AK: Overcoming platinum resistance in ovarian carcinoma. Expert Opin Investig Drugs. 19:1339–1354. 2010. View Article : Google Scholar : PubMed/NCBI

17 

van Moorsel CJ, Pinedo HM, Veerman G, et al: Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines. Br J Cancer. 80:981–990. 1999.

18 

Rose PG, Mossbruger K, Fusco N, Smrekar M, Eaton S and Rodriguez M: Gemcitabine reverses cisplatin resistance: demonstration of activity in platinum- and multidrug-resistant ovarian and peritoneal carcinoma. Gynecol Oncol. 88:17–21. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Nagourney RA, Brewer CA, Radecki S, et al: Phase II trial of gemcitabine plus cisplatin repeating doublet therapy in previously treated, relapsed ovarian cancer patients. Gynecol Oncol. 88:35–39. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Tewari D, Monk BJ, Hunter M, Falkner CA and Burger RA: Gemcitabine and cisplatin chemotherapy an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma. Invest New Drugs. 22:475–480. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Brewer CA, Blessing JA, Nagourney RA, Morgan M and Hanjani P: Cisplatin plus gemcitabine in platinum-refractory ovarian or primary peritoneal cancer: a phase II study of the Gynecologic Oncology Group. Gynecol Oncol. 103:446–450. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Bozas G, Bamias A, Koutsoukou V, Efstathiou E, Gika D, Papadimitriou CA and Dimopoulos MA: Biweekly gemcitabine and cisplatin in platinum-resistant/refractory, paclitaxel-pretreated, ovarian and peritoneal carcinoma. Gynecol Oncol. 104:580–585. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Rose PG: Gemcitabine reverses platinum resistance in platinum-resistant ovarian and peritoneal carcinoma. Int J Gynecol Cancer. 15(Suppl 1): 18–22. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Griffiths RW, Zee YK, Evans S, et al: Outcomes after multiple lines of chemotherapy for platinum-resistant epithelial cancers of the ovary, peritoneum, and fallopian tube. Int J Gynecol Cancer. 21:58–65. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu Q, Xu N, Fang W, Zhao P, Mao C, Zheng Y and Mou H: Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature. Oncol Lett 5: 1601-1604, 2013.
APA
Xu, Q., Xu, N., Fang, W., Zhao, P., Mao, C., Zheng, Y., & Mou, H. (2013). Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature. Oncology Letters, 5, 1601-1604. https://doi.org/10.3892/ol.2013.1232
MLA
Xu, Q., Xu, N., Fang, W., Zhao, P., Mao, C., Zheng, Y., Mou, H."Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature". Oncology Letters 5.5 (2013): 1601-1604.
Chicago
Xu, Q., Xu, N., Fang, W., Zhao, P., Mao, C., Zheng, Y., Mou, H."Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature". Oncology Letters 5, no. 5 (2013): 1601-1604. https://doi.org/10.3892/ol.2013.1232
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Q, Xu N, Fang W, Zhao P, Mao C, Zheng Y and Mou H: Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature. Oncol Lett 5: 1601-1604, 2013.
APA
Xu, Q., Xu, N., Fang, W., Zhao, P., Mao, C., Zheng, Y., & Mou, H. (2013). Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature. Oncology Letters, 5, 1601-1604. https://doi.org/10.3892/ol.2013.1232
MLA
Xu, Q., Xu, N., Fang, W., Zhao, P., Mao, C., Zheng, Y., Mou, H."Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature". Oncology Letters 5.5 (2013): 1601-1604.
Chicago
Xu, Q., Xu, N., Fang, W., Zhao, P., Mao, C., Zheng, Y., Mou, H."Complete remission of platinum-refractory primary Fallopian tube carcinoma with third-line gemcitabine plus cisplatin: A case report and review of the literature". Oncology Letters 5, no. 5 (2013): 1601-1604. https://doi.org/10.3892/ol.2013.1232
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team