Role of inflammation in oral carcinogenesis (Part II): CD8, FOXP3, TNF-α, TGF-β and NF-κB expression

Piva,Marta  Rabello; De Souza,Lélia   Batista; Martins‑Filho,Paulo  Ricardo Saquete; Nonaka,Cassiano  Francisco Weege; De Santana Santos,Thiago; De Souza Andrade,Emanuel   Sávio; Piva,Diogo

doi:10.3892/ol.2013.1302

Role of inflammation in oral carcinogenesis (Part II): CD8, FOXP3, TNF-α, TGF-β and NF-κB expression

Authors:
- Marta Rabello Piva
- Lélia Batista De Souza
- Paulo Ricardo Saquete Martins‑Filho
- Cassiano Francisco Weege Nonaka
- Thiago De Santana Santos
- Emanuel Sávio De Souza Andrade
- Diogo Piva
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Affiliations: Department of Oral Pathology, Federal University of Sergipe, Sanatório, Aracaju 49060-100, Sergipe, Brazil, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal 59072‑970, Rio Grande do Norte, Brazil, Department of Health Education, Federal University of Sergipe, Lagarto 49400-000, Sergipe, Brazil, Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto 14040‑904, São Paulo, Brazil, Department of Oral and Maxillofacial Surgery, Pernambuco University, Camaragibe 54753‑220, Pernambuco, Brazil, Department of Surgery, Federal University of São Paulo (EPM/UNIFESP), Vila Clementino, São Paulo 04023-062, Brazil
Published online on: April 11, 2013 https://doi.org/10.3892/ol.2013.1302
Pages: 1909-1914

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Abstract

Due to the frequent presence of inflammation in cases of carcinoma and its use as a parameter for the assessment of tumor aggressiveness, the role of inflammation in oral carcinogenesis was investigated. This was performed by evaluating the expression of cellular markers, cytokines and nuclear transcription factors that identify the cells that participate in the antitumor defense in cases of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). A semi-quantitative immunohistochemical analysis was performed for the transcription factors cluster of differentiation 8 (CD8), forkhead box P3 (FOXP3), transforming growth factor (TGF)-β, tumor necrosis factor (TNF)-α and nuclear factor κ-light chain enhancer of activated B-cells (NF-κB), in cases of OED and OSCC. CD8, TGF-β, TNF-α and NF-κB participated in the processes of tumor transformation and progression. The presence of inflammatory infiltrate in cases of OED favors the transformation and invasion process when stromal TNF-α and NF-kB are overexpressed, as NF-kB activated by TNF-α during inflammation predisposes the lesion to transformation, functioning as a link between inflammation and cancer. The control of these inflammatory mediators may prevent malignant transformation in the oral cavity.

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