CyberKnife therapy of 24 multiple brain metastases from lung cancer: A case report

Yang,Guiqing; Wang,Yishan; Wang,Yuanyuan; Lin,Sixiang; Sun,Dongning

doi:10.3892/ol.2013.1383

CyberKnife therapy of 24 multiple brain metastases from lung cancer: A case report

Authors:
- Guiqing Yang
- Yishan Wang
- Yuanyuan Wang
- Sixiang Lin
- Dongning Sun
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Affiliations: Center for Tumor Treatment, People's Liberation Army 107th Hospital, Yantai, Shandong 264003, P.R. China, Binzhou Medical College, Lai Shan Qu, Yantai, Shandong 264003, P.R. China
Published online on: June 7, 2013 https://doi.org/10.3892/ol.2013.1383
Pages: 534-536

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Abstract

Brain metastasis is a significant cause of morbidity and mortality and a critical complication of non‑central nervous system primary carcinoma. The present study describes the clinical case of a 46-year-old male with lung cancer and life‑threatening brain metastases. The patient was diagnosed with lung cancer with a clinical stage of T2N0M1 (stage Ⅳ). Six months after the initial diagnosis and administration of conformal radiotherapy combined with three cycles of chemotherapy, an enhanced computed tomography (CT) scan of the brain revealed abnormalities with double-dosing of intravenous contrast. The CT scan identified >24 lesions scattered in the whole brain. The patient was treated with three-fraction Cyberknife radiotherapy at 22 Gy, delivered to the brain metastases at the Center for Tumor Treatment of People's Liberation Army 107th Hospital. Following CyberKnife therapy, a CT scan of the brain revealed that most of the tumors had disappeared with almost no residual traces. The stereotactic radiosurgery (SRS) conducted using CyberKnife, an image-guided frameless robotic technology for whole-body radiosurgery, had produced a marked response. The present case report demonstrates that CyberKnife therapy plays a significant role in the management of multiple metastatic brain tumors.

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