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September 2013 Volume 6 Issue 3

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Article

Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients

  • Authors:
    • Peng‑Chan Lin
    • Yih‑Jyh Lin
    • Chung‑Ta Lee
    • Hsiao‑Sheng Liu
    • Jenq‑Chang Lee
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C., Department of Surgery, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C., Department of Pathology, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C., Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C.
  • Pages: 733-739
    |
    Published online on: June 26, 2013
       https://doi.org/10.3892/ol.2013.1426
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Abstract

The development of colorectal cancer (CRC) is commonly accompanied by the overexpression of the cyclooxygenase‑2 (COX‑2) gene, with high levels being most common in early colorectal lesions. In the present study, we hypothesized that the expression of COX‑2 in normal mucosa affects the expression of COX‑2 in adjacent tumors. COX‑2 protein expression levels were determined in tumor tissues and the adjacent normal mucosa of 49 paired clinical CRC specimens using western blotting and immunohistochemistry (IHC) staining. The majority of specimens exhibited an extremely low level of COX‑2 expression in the tumor tissue and a markedly higher expression level in the adjacent normal tissue, however, high COX‑2 expression in the tumor was shown to correlate with a high recurrence rate and poor overall survival. Of the nine CRC cell lines, HT29 showed consistently higher levels of COX‑2 expression. Therefore, COX‑2 expression in the normal tissue adjacent to the tumor may be involved in the tumorigenesis of CRC. These observations are likely to be useful in determining the significance of COX‑2 expression in the tumorigenesis of CRC.
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1 

Vogelstein B, Fearon ER, Hamilton SR, et al: Genetic alterations during colorectal-tumor development. N Engl J Med. 319:525–532. 1988. View Article : Google Scholar : PubMed/NCBI

2 

Bruce WR, Wolever TM and Giacca A: Mechanisms linking diet and colorectal cancer: the possible role of insulin resistance. Nutr Cancer. 37:19–26. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Balkwill F and Mantovani A: Inflammation and cancer: back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Hussain SP, Hofseth LJ and Harris CC: Radical causes of cancer. Nat Rev Cancer. 3:276–285. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Mariani F, Sena P, Marzona L, Riccio M, Fano R, Manni P, et al: Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. Cancer Lett. 279:221–229. 2009. View Article : Google Scholar

6 

Adegboyega PA, Ololade O, Saada J, Mifflin R, Di Mari JF and Powell DW: Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. Clin Cancer Res. 10:5870–5879. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Hawcroft G, Ko CW and Hull MA: Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. Oncogene. 26:3006–3019. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Sun Y, Tang XM, Half E, Kuo MT and Sinicrope FA: Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res. 62:6323–6328. 2002.PubMed/NCBI

9 

Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S and DuBois RN: Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 107:1183–1188. 1994.PubMed/NCBI

10 

Levy BD, Clish CB, Schmidt B, Gronert K and Serhan CN: Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol. 2:612–619. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Charalambous MP, Lightfoot T, Speirs V, Horgan K and Gooderham NJ: Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue. Br J Cancer. 101:106–115. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, et al: Expression of cyclooxygenase-1 and −2 in human colorectal cancer. Cancer Res. 55:3785–3789. 1995.

13 

Williams CS, Mann M and DuBois RN: The role of cyclooxygenases in inflammation, cancer and development. Oncogene. 18:7908–7916. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Zhang M, Deng CS, Zheng JJ and Xia J: Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis. Acta Pharmacol Sin. 27:1071–1077. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Yamazaki K, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Kanemura N, Araki H, et al: Synergistic effects of RXR alpha and PPAR gamma ligands to inhibit growth in human colon cancer cells - phosphorylated RXR alpha is a critical target for colon cancer management. Gut. 56:1557–1563. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Kitamura S, Miyazaki Y, Shinomura Y, Kondo S, Kanayama S and Matsuzawa Y: Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells. Jpn J Cancer Res. 90:75–80. 1999. View Article : Google Scholar

17 

Kohno H, Suzuki R, Sugie S and Tanaka T: Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. BMC Cancer. 5:462005. View Article : Google Scholar : PubMed/NCBI

18 

Yuri M, Sasahira T, Nakai K, Ishimaru S, Ohmori H and Kuniyasu H: Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. Histopathology. 51:520–527. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Sarraf P, Mueller E, Jones D, King FJ, DeAngelo DJ, Partridge B, et al: Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med. 4:1046–1052. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Tseng YS, Tzeng CC, Huang CY, Chen PH, Chiu AW, Hsu PY, et al: Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Lett. 241:93–101. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Cheng HL, Trink B, Tzai TS, Liu HS, Chan SH, Ho CL, Sidransky D and Chow NH: Overexpression of c-met as a prognostic indicator for transitional cell carcinoma of the urinary bladder: a comparison with p53 nuclear accumulation. J Clin Oncol. 20:1544–1550. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Cutler NS, Graves-Deal R, LaFleur BJ, Gao Z, Boman BM, Whitehead RH, et al: Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. Cancer Res. 63:1748–1751. 2003.PubMed/NCBI

23 

DuBois RN, Shao J, Tsujii M, Sheng H and Beauchamp RD: G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res. 56:733–737. 1996.PubMed/NCBI

24 

Vandoros GP, Konstantinopoulos PA, Sotiropoulou-Bonikou G, Kominea A, Papachristou GI, Karamouzis MV, et al: PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. J Cancer Res Clin Oncol. 132:76–84. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Karnes WE Jr, Shattuck-Brandt R, Burgart LJ, DuBois RN, Tester DJ, Cunningham JM, et al: Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res. 58:5473–5477. 1998.PubMed/NCBI

26 

Zuo X, Wu Y, Morris JS, Stimmel JB, Leesnitzer LM, Fischer SM, Lippman SM and Shureiqi I: Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. Oncogene. 25:1225–1241. 2006. View Article : Google Scholar : PubMed/NCBI

27 

DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL and Lazar MA: The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. Carcinogenesis. 19:49–53. 1998. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin PC, Lin YJ, Lee CT, Liu HS and Lee JC: Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients. Oncol Lett 6: 733-739, 2013.
APA
Lin, P., Lin, Y., Lee, C., Liu, H., & Lee, J. (2013). Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients. Oncology Letters, 6, 733-739. https://doi.org/10.3892/ol.2013.1426
MLA
Lin, P., Lin, Y., Lee, C., Liu, H., Lee, J."Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients". Oncology Letters 6.3 (2013): 733-739.
Chicago
Lin, P., Lin, Y., Lee, C., Liu, H., Lee, J."Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients". Oncology Letters 6, no. 3 (2013): 733-739. https://doi.org/10.3892/ol.2013.1426
Copy and paste a formatted citation
x
Spandidos Publications style
Lin PC, Lin YJ, Lee CT, Liu HS and Lee JC: Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients. Oncol Lett 6: 733-739, 2013.
APA
Lin, P., Lin, Y., Lee, C., Liu, H., & Lee, J. (2013). Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients. Oncology Letters, 6, 733-739. https://doi.org/10.3892/ol.2013.1426
MLA
Lin, P., Lin, Y., Lee, C., Liu, H., Lee, J."Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients". Oncology Letters 6.3 (2013): 733-739.
Chicago
Lin, P., Lin, Y., Lee, C., Liu, H., Lee, J."Cyclooxygenase‑2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients". Oncology Letters 6, no. 3 (2013): 733-739. https://doi.org/10.3892/ol.2013.1426
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