Clinical application of iodine‑eluting stent in patients with advanced esophageal cancer

Dai,Zhenbo; Zhou,Dejun; Hu,Jianzhang; Zhang,Lei; Lin,Yunshou; Zhang,Jing; Li,Fengling; Liu,Peng; Li,Hua; Cao,Fuliang

doi:10.3892/ol.2013.1466

Clinical application of iodine‑eluting stent in patients with advanced esophageal cancer

Authors:
- Zhenbo Dai
- Dejun Zhou
- Jianzhang Hu
- Lei Zhang
- Yunshou Lin
- Jing Zhang
- Fengling Li
- Peng Liu
- Hua Li
- Fuliang Cao
View Affiliations

Affiliations: Key Laboratory of Cancer Prevention and Therapy, Endoscopy Center, Tianjin Medical University, Cancer Institute and Hospital, Tianjin 300060, P.R. China, Tianjin Lung Cancer Center, Department of Thoracic Surgery, Tianjin Medical University, Cancer Institute and Hospital, Tianjin 300060, P.R. China, Tianjin Medical University, Tianjin 300070, P.R. China
Published online on: July 15, 2013 https://doi.org/10.3892/ol.2013.1466
Pages: 713-718

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of the present study was to compare the clinical effectiveness of an iodine‑eluting stent with a conventional stent in patients with advanced esophageal cancer. Patients with malignant esophageal cancer were randomly assigned to receive a conventional stent (group A) or an iodine‑eluting stent (group B). Following implantation, the relief from dysphagia, survival time, routine blood tests, thyroid function examination and complications were compared in the two groups. Groups A and B consisted of 36 and 31 patients, respectively. The mean value that the dysphagia score decreased by was significantly lower in group A (0.83) compared with group B (1.65). The median survival time was longer in group B compared with group A (P=0.0022). No significant differences were observed in the severe complications between the two groups (P=0.084). The iodine‑eluting esophageal stent is a relatively safe, feasible and effective treatment for malignant esophageal strictures.

View Figures

View References

1	Katsanos K, Sabharwal T and Adam A: Stenting of the upper gastrointestinal tract: current status. Cardiovasc Intervent Radiol. 33:690–705. 2010. View Article : Google Scholar : PubMed/NCBI
2	Park JG, Jung GS, Oh KS and Park SJ: Double-layered PTFE-covered nitinol stents: experience in 32 patients with malignant esophageal strictures. Cardiovasc Intervent Radiol. 33:772–779. 2010. View Article : Google Scholar : PubMed/NCBI
3	Kim KR, Shin JH, Song HY, Ko GY, Kim JH, Yoon HK and Sung KB: Palliative treatment of malignant esophagopulmonary fistulas with covered expandable metallic stents. AJR Am J Roentgenol. 193:W278–W282. 2009. View Article : Google Scholar : PubMed/NCBI
4	White RE, Parker RK, Fitzwater JW, Kasepoi Z and Topazian M: Stents as sole therapy for oesophageal cancer: a prospective analysis of outcomes after placement. Lancet Oncol. 10:240–246. 2009. View Article : Google Scholar : PubMed/NCBI
5	Knyrim K, Wagner HJ, Bethge N, Keymling M and Vakil N: A controlled trial of an expansile metal stent for palliation of esophageal obstruction due to inoperable cancer. N Engl J Med. 329:1302–1307. 1993. View Article : Google Scholar : PubMed/NCBI
6	Song HY, Do YS, Han YM, Sung KB, Choi EK, Sohn KH, Kim HR, Kim SH and Min YI: Covered, expandable esophageal metallic stent tubes: experiences in 119 patients. Radiology. 193:689–695. 1994. View Article : Google Scholar : PubMed/NCBI
7	Christie NA, Buenaventura PO, Fernando HC, Nguyen NT, Weigel TL, Ferson PF and Luketich JD: Results of expandable metal stents for malignant esophageal obstruction in 100 patients: short-term and long-term follow-up. Ann Thorac Surg. 71:1797–1802. 2001. View Article : Google Scholar : PubMed/NCBI
8	Sabharwal T, Hamady MS, Chui S, Atkinson S, Mason R and Adam A: A randomized prospective comparison of the Flamingo Wallstent and Ultraflex stent for palliation of dysphagia associated with lower third oesophageal cancer. Gut. 52:922–926. 2003. View Article : Google Scholar
9	Guo JH, Teng GJ, Zhu GY, He SC, Fang W, Deng G and Li GZ: Self-expandable esophageal stent loaded with 125I seeds: initial experience in patients with advanced esophageal cancer. Radiology. 247:574–581. 2008. View Article : Google Scholar : PubMed/NCBI
10	Zhongmin W, Xunbo H, Jun C, Gang H, Kemin C, Yu L and Fenju L: Intraluminal radioactive stent compared with covered stent alone for the treatment of malignant esophageal stricture. Cardiovasc Intervent Radiol. 35:351–358. 2012. View Article : Google Scholar
11	Sabharwal T, Morales JP, Irani FG and Adam A; CIRSE. Cardiovascular and Interventional Radiological Society of Europe: Quality improvement guidelines for placement of esophageal stents. Cardiovasc Intervent Radiol. 28:284–288. 2005. View Article : Google Scholar : PubMed/NCBI
12	Huang GJ, Wang LJ, Liu JS, Cheng GY, Zhang DW, Wang GQ and Zhang RG: Surgery of esophageal carcinoma. Semin Surg Oncol. 1:74–83. 1985. View Article : Google Scholar
13	McQueen AS, Eljabu W, Latimer J and Raju PP: Thoracic discitis as a complication of self-expanding metallic stents in esophageal carcinoma. Cardiovasc Intervent Radiol. 34(Suppl 2): S300–S302. 2011. View Article : Google Scholar : PubMed/NCBI
14	Wenger U, Luo J, Lundell L and Lagergren J: A nationwide study of the use of self-expanding stents in patients with esophageal cancer in Sweden. Endoscopy. 37:329–334. 2005. View Article : Google Scholar : PubMed/NCBI
15	McGrath JP, Browne M, Riordan C, Ravi N and Reynolds JV: Expandable metal stents in the palliation of malignant dysphagia and oesophageal-respiratory fistulae. Ir Med J. 94:270–272. 2001.PubMed/NCBI
16	Sarper A, Oz N, Cihangir C, Demircan A and Isin E: The efficacy of self-expanding metal stents for palliation of malignant esophageal strictures and fistulas. Eur J Cardiothorac Surg. 23:794–798. 2003. View Article : Google Scholar : PubMed/NCBI
17	Bartelsman JF, Bruno MJ, Jensema AJ, Haringsma J, Reeders JW and Tytgat GN: Palliation of patients with esophagogastric neoplasms by insertion of a covered expandable modified Gianturco-Z endoprosthesis: experiences in 153 patients. Gastrointest Endosc. 51:134–138. 2000. View Article : Google Scholar
18	Wang MQ, Sze DY, Wang ZP, Wang ZQ, Gao YA and Dake MD: Delayed complications after esophageal stent placement for treatment of malignant esophageal obstructions and esophagorespiratory fistulas. J Vasc Interv Radiol. 12:465–474. 2001. View Article : Google Scholar
19	Baron TH: Expandable metal stents for the treatment of cancerous obstruction of the gastrointestinal tract. N Engl J Med. 344:1681–1687. 2001. View Article : Google Scholar : PubMed/NCBI
20	Siersema PD, Tan TG, Sutorius FF, Dees J and van Blankenstein M: Massive hemorrhage caused by a perforating Gianturco-Z stent resulting in an aortoesophageal fistula. Endoscopy. 29:416–420. 1997. View Article : Google Scholar : PubMed/NCBI