1
|
Li D, Xie K, Wolff R and Abbruzzese JL:
Pancreatic cancer. Lancet. 363:1049–1057. 2004. View Article : Google Scholar
|
2
|
Guo X and Cui Z: Current diagnosis and
treatment of pancreatic cancer in China. Pancreas. 31:13–22. 2005.
View Article : Google Scholar : PubMed/NCBI
|
3
|
Siegel R, Naishadham D and Jemal A: Cancer
statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar
|
4
|
Hingorani SR, Wang L, Multani AS, et al:
Trp53R172H and KrasG12D cooperate to promote chromosomal
instability and widely metastatic pancreatic ductal adenocarcinoma
in mice. Cancer Cell. 7:469–483. 2005. View Article : Google Scholar : PubMed/NCBI
|
5
|
Bardeesy N, Aguirre AJ, Chu GC, et al:
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression
of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci USA.
103:5947–5952. 2006. View Article : Google Scholar : PubMed/NCBI
|
6
|
Feldmann G, Beaty R, Hruban RH and Maitra
A: Molecular genetics of pancreatic intraepithelial neoplasia. J
Hepatobiliary Pancreat Surg. 14:224–232. 2007. View Article : Google Scholar : PubMed/NCBI
|
7
|
Westmoreland JJ, Wang Q, Bouzaffour M, et
al: Pdk1 activity controls proliferation, survival, and growth of
developing pancreatic cells. Dev Biol. 334:285–298. 2009.
View Article : Google Scholar : PubMed/NCBI
|
8
|
Bushati N and Cohen SM: microRNA
functions. Annu Rev Cell Dev Biol. 23:175–205. 2007. View Article : Google Scholar
|
9
|
Carthew RW and Sontheimer EJ: Origins and
mechanisms of miRNAs and siRNAs. Cell. 136:642–655. 2009.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Ambros V: The functions of animal
microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI
|
11
|
Bartel DP: MicroRNAs: genomics,
biogenesis, mechanism, and function. Cell. 116:281–297. 2004.
View Article : Google Scholar : PubMed/NCBI
|
12
|
He L and Hannon GJ: MicroRNAs: small RNAs
with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004.
View Article : Google Scholar : PubMed/NCBI
|
13
|
Zaman MS, Chen Y, Deng G, et al: The
functional significance of microRNA-145 in prostate cancer. Br J
Cancer. 103:256–264. 2010. View Article : Google Scholar : PubMed/NCBI
|
14
|
Yu S, Lu Z, Liu C, et al: miRNA-96
suppresses KRAS and functions as a tumor suppressor gene in
pancreatic cancer. Cancer Res. 70:6015–6025. 2010. View Article : Google Scholar : PubMed/NCBI
|
15
|
Schickel R, Park SM, Murmann AE and Peter
ME: miR-200c regulates induction of apoptosis through CD95 by
targeting FAP-1. Mol Cell. 38:908–915. 2010. View Article : Google Scholar : PubMed/NCBI
|
16
|
Szafranska AE, Davison TS, John J, et al:
MicroRNA expression alterations are linked to tumorigenesis and
non-neoplastic processes in pancreatic ductal adenocarcinoma.
Oncogene. 26:4442–4452. 2007. View Article : Google Scholar : PubMed/NCBI
|
17
|
Avissar M, Christensen BC, Kelsey KT and
Marsit CJ: MicroRNA expression ratio is predictive of head and neck
squamous cell carcinoma. Clin Cancer Res. 15:2850–2855. 2009.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Ladeiro Y, Couchy G, Balabaud C, et al:
MicroRNA profiling in hepatocellular tumors is associated with
clinical features and oncogene/tumor suppressor gene mutations.
Hepatology. 47:1955–1963. 2008. View Article : Google Scholar : PubMed/NCBI
|
19
|
Zhou J, Song S, Cen J, Zhu D, Li D and
Zhang Z: MicroRNA-375 is downregulated in pancreatic cancer and
inhibits cell proliferation in vitro. Oncol Res. 20:197–203. 2012.
View Article : Google Scholar : PubMed/NCBI
|
20
|
Hamilton SR and Aaltonen LA: Pathology and
genetics of tumours of the digestive system. World Health
Organization Classification of Tumours. IARC Press; Lyon: 2000
|
21
|
Wang XQ, Luk JM, Leung PP, et al:
Alternative mRNA splicing of liver intestine-cadherin in
hepatocellular carcinoma. Clin Cancer Res. 11:483–489.
2005.PubMed/NCBI
|
22
|
Wong KF, Luk JM, Cheng RH, et al:
Characterization of two novel LPS-binding sites in leukocyte
integrin betaA domain. FASEB J. 21:3231–3239. 2007. View Article : Google Scholar : PubMed/NCBI
|
23
|
Liu LX, Lee NP, Chan VW, et al: Targeting
cadherin-17 inactivates Wnt signaling and inhibits tumor growth in
liver carcinoma. Hepatology. 50:1453–1463. 2009. View Article : Google Scholar : PubMed/NCBI
|
24
|
Kozma SC and Thomas G: Regulation of cell
size in growth, development and human disease: PI3K, PKB and S6K.
Bioessays. 24:65–71. 2002. View Article : Google Scholar : PubMed/NCBI
|
25
|
Mora A, Komander D, van Aalten DM and
Alessi DR: PDK1, the master regulator of AGC kinase signal
transduction. Semin Cell Dev Biol. 15:161–170. 2004. View Article : Google Scholar : PubMed/NCBI
|
26
|
Storz P and Toker A:
3′-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase
signaling. Front Biosci. 7:d886–d902. 2002.
|
27
|
El Ouaamari A, Baroukh N, Martens GA, et
al: miR-375 targets 3′-phosphoinositide-dependent protein kinase-1
and regulates glucose-induced biological responses in pancreatic
beta-cells. Diabetes. 57:2708–2717. 2008.
|
28
|
Bloomston M, Frankel WL, Petrocca F, et
al: MicroRNA expression patterns to differentiate pancreatic
adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA.
297:1901–1908. 2007. View Article : Google Scholar : PubMed/NCBI
|
29
|
Hou Z, Xie L, Yu L, Qian X and Liu B:
MicroRNA-146a is down-regulated in gastric cancer and regulates
cell proliferation and apoptosis. Med Oncol. 29:886–892. 2012.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Lee EJ, Gusev Y, Jiang J, et al:
Expression profiling identifies microRNA signature in pancreatic
cancer. Int J Cancer. 120:1046–1054. 2007. View Article : Google Scholar : PubMed/NCBI
|
31
|
Poy MN, Eliasson L, Krutzfeldt J, et al: A
pancreatic islet-specific microRNA regulates insulin secretion.
Nature. 432:226–230. 2004. View Article : Google Scholar : PubMed/NCBI
|
32
|
Liu AM, Poon RT and Luk JM: MicroRNA-375
targets Hippo-signaling effector YAP in liver cancer and inhibits
tumor properties. Biochem Biophys Res Commun. 394:623–627. 2010.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Ding L, Xu Y, Zhang W, et al: MiR-375
frequently downregulated in gastric cancer inhibits cell
proliferation by targeting JAK2. Cell Res. 20:784–793. 2010.
View Article : Google Scholar : PubMed/NCBI
|
34
|
Li X, Lin R and Li J: Epigenetic silencing
of microRNA-375 regulates PDK1 expression in esophageal cancer. Dig
Dis Sci. 56:2849–2856. 2011. View Article : Google Scholar : PubMed/NCBI
|
35
|
Tsukamoto Y, Nakada C, Noguchi T, et al:
MicroRNA-375 is downregulated in gastric carcinomas and regulates
cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res.
70:2339–2349. 2010. View Article : Google Scholar : PubMed/NCBI
|