A2780 human ovarian cancer cells with acquired paclitaxel resistance display cancer stem cell properties Corrigendum in /10.3892/ol.2022.13526

Han,Xiaofeng; Du,Fangfang; Jiang,Li; Zhu,Yifei; Chen,Zhen; Liu,Yanjun; Hong,Tingting; Wang,Teng; Mao,Yong; Wu,Xiaohong; Bruce,Iain C.; Jin,Jian; Ma,Xin; Hua,Dong

doi:10.3892/ol.2013.1568

A2780 human ovarian cancer cells with acquired paclitaxel resistance display cancer stem cell properties

Corrigendum in: /10.3892/ol.2022.13526

Authors:
- Xiaofeng Han
- Fangfang Du
- Li Jiang
- Yifei Zhu
- Zhen Chen
- Yanjun Liu
- Tingting Hong
- Teng Wang
- Yong Mao
- Xiaohong Wu
- Iain C. Bruce
- Jian Jin
- Xin Ma
- Dong Hua
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Affiliations: School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, School of Pharmaceutical Sciences, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, Affiliated Hospital, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China
Published online on: September 6, 2013 https://doi.org/10.3892/ol.2013.1568
Pages: 1295-1298

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Abstract

The use of chemotherapy to treat cancer is effective, but chemoresistance reduces this efficacy. Chemotherapy resistance involves several mechanisms, including the cancer stem cell (CSC) concept. The aim of the present study was to assess whether paclitaxel-resistant epithelial ovarian carcinoma is capable of generating cells with CSC-like properties. Using the paclitaxel-resistant A2780/PTX cell line, it was demonstrated that high aldehyde dehydrogenase 1 (ALDH1) activity identifies CSCs from diverse sources. Furthermore, the A2780/PTX cells had a strong ability to form colonies in soft agar assays. Notably, it was demonstrated that the inhibition of the PI3K signaling pathway abolished colony formation. These data suggest that there is a link between paclitaxel resistance and CSC enrichment. It is possible that therapeutic benefits, such as the restoration of chemosensitivity or the suppression of tumorigenicity, may be enabled by gaining further insights into the mechanisms underlying chemoresistance and the generation of CSCs.

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