Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling

  • Authors:
    • Yukio Fujiwara
    • Kiyomi Takaishi
    • Junko Nakao
    • Tsuyoshi Ikeda
    • Hidetaka Katabuchi
    • Motohiro Takeya
    • Yoshihiro Komohara
  • View Affiliations

  • Published online on: September 18, 2013     https://doi.org/10.3892/ol.2013.1591
  • Pages: 1619-1623
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Abstract

Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients. The mechanisms of chemoresistance are complex and studies have implicated signal transducer and activator of transcription 3 (STAT3) signaling in the chemoresistance of cancer cells. The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. CA also markedly enhanced the anticancer effect of paclitaxel, cisplatin and doxorubicin. In addition, CA abrogated the cell‑cell interactions between macrophages and epithelial ovarian cancer cells and inhibited the macrophage‑induced activation of epithelial ovarian cancer cells. These data indicated that CA was able to reverse the chemoresistance of epithelial ovarian cancer cells and suppress the cell‑cell interaction with tumorigenic macrophages. Thus, CA may be useful as an adjuvant treatment to patients with advanced ovarian and other types of cancer due to the multiple anticancer effects.
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December 2013
Volume 6 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M and Komohara Y: Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. Oncol Lett 6: 1619-1623, 2013
APA
Fujiwara, Y., Takaishi, K., Nakao, J., Ikeda, T., Katabuchi, H., Takeya, M., & Komohara, Y. (2013). Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. Oncology Letters, 6, 1619-1623. https://doi.org/10.3892/ol.2013.1591
MLA
Fujiwara, Y., Takaishi, K., Nakao, J., Ikeda, T., Katabuchi, H., Takeya, M., Komohara, Y."Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling". Oncology Letters 6.6 (2013): 1619-1623.
Chicago
Fujiwara, Y., Takaishi, K., Nakao, J., Ikeda, T., Katabuchi, H., Takeya, M., Komohara, Y."Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling". Oncology Letters 6, no. 6 (2013): 1619-1623. https://doi.org/10.3892/ol.2013.1591