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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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December 2013 Volume 6 Issue 6

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Case Report

Bevacizumab treatment for advanced non‑small cell lung cancer: A case report

  • Authors:
    • Yun Fan
    • Zhiyu Huang
    • Weimin Mao
  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 1779-1783
    |
    Published online on: October 4, 2013
       https://doi.org/10.3892/ol.2013.1603
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Abstract

The safety of Avastin in lung cancer (SAiL) study is a multi‑center, open‑source, stand‑alone study. Patients with untreated, locally advanced, metastatic or recurrent non-squamous non‑small cell lung cancer (NSCLC) were administered up to six cycles of chemotherapy combined with bevacizumab‑humanized monoclonal antibodies, followed by maintenance therapy with bevacizumab until further progression of the disease. From August, 2006 to July, 2008 there were a total of 2,172 patients enrolled in the study, with a median progression‑free survival time of 7.8 months and an overall survival time of 14.6 months. The present study describes the case of a 54‑year‑old male with lung cancer and T3N0M1 subcutaneous metastasis, which was initially treated with bevacizumab‑combined carboplatin/paclitaxel (C/P) therapy and then maintained solely with bevacizumab for five years. Following six cycles of C/P bevacizumab treatment, the therapeutic evaluation revealed a stable disease (SD). The patient was kept on bevacizumab maintenance therapy for 50 months without disease progression until a persistent 3+ proteinuria was diagnosed in a follow‑up review, which led to bevacizumab withdrawal and concomitant tumor growth. The present study concluded that the long‑term application of bevacizumab monoclonal antibodies (mABs) was safe in a late‑stage non‑small cell lung cancer patient. The major adverse reaction that was exhibited was proteinuria, which was associated with the cumulative dose of bevacizumab and was able to be reversed by withdrawal. Patients with a prolonged SD may benefit from bevacizumab maintenance therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Fan Y, Huang Z and Mao W: Bevacizumab treatment for advanced non‑small cell lung cancer: A case report. Oncol Lett 6: 1779-1783, 2013.
APA
Fan, Y., Huang, Z., & Mao, W. (2013). Bevacizumab treatment for advanced non‑small cell lung cancer: A case report. Oncology Letters, 6, 1779-1783. https://doi.org/10.3892/ol.2013.1603
MLA
Fan, Y., Huang, Z., Mao, W."Bevacizumab treatment for advanced non‑small cell lung cancer: A case report". Oncology Letters 6.6 (2013): 1779-1783.
Chicago
Fan, Y., Huang, Z., Mao, W."Bevacizumab treatment for advanced non‑small cell lung cancer: A case report". Oncology Letters 6, no. 6 (2013): 1779-1783. https://doi.org/10.3892/ol.2013.1603
Copy and paste a formatted citation
x
Spandidos Publications style
Fan Y, Huang Z and Mao W: Bevacizumab treatment for advanced non‑small cell lung cancer: A case report. Oncol Lett 6: 1779-1783, 2013.
APA
Fan, Y., Huang, Z., & Mao, W. (2013). Bevacizumab treatment for advanced non‑small cell lung cancer: A case report. Oncology Letters, 6, 1779-1783. https://doi.org/10.3892/ol.2013.1603
MLA
Fan, Y., Huang, Z., Mao, W."Bevacizumab treatment for advanced non‑small cell lung cancer: A case report". Oncology Letters 6.6 (2013): 1779-1783.
Chicago
Fan, Y., Huang, Z., Mao, W."Bevacizumab treatment for advanced non‑small cell lung cancer: A case report". Oncology Letters 6, no. 6 (2013): 1779-1783. https://doi.org/10.3892/ol.2013.1603
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