99mTcO4- scintigraphic detection of follicular thyroid cancer and multiple metastatic lesions: A case report

Wang,Chang‑Yin; Xiao,Bang‑Ru; Shen,Mei‑Juan; Shen,Ying; Cui,Kun‑Wei

doi:10.3892/ol.2013.1639

99mTcO4- scintigraphic detection of follicular thyroid cancer and multiple metastatic lesions: A case report

Authors:
- Chang‑Yin Wang
- Bang‑Ru Xiao
- Mei‑Juan Shen
- Ying Shen
- Kun‑Wei Cui
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Affiliations: Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Nuclear Medicine, Jingzhou Center Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jingzhou, Hubei 434000, P.R. China
Published online on: October 23, 2013 https://doi.org/10.3892/ol.2013.1639
Pages: 1729-1732

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Abstract

99mTcO4- thyroid imaging is often used to detect thyroid diseases that are confined to the neck. However, this examination is not frequently used to detect metastatic lesions of thyroid cancer in the whole body, while 131I imaging is often used to detect the metastases of differentiated thyroid cancers. The present study performed 99mTcO4- thyroid imaging for a 69‑year‑old patient with a thyroid nodule and incidentally identified a lesion with abnormally increased 99mTcO4- uptake in the chest of the patient. Furthermore, a whole‑body scan was performed for this patient and multiple lesions with increased 99mTcO4- uptake were identified. The results confirmed that these lesions were follicular thyroid cancer and the metastatic lesions were distributed in numerous locations. The results revealed that analysis of the whole body is significant when regional lesions with abnormally increased 99mTcO4- uptake outside of thyroid tissues are identified by routine 99mTcO4- thyroid imaging.

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1	Grebe SK and Hay ID: Follicular thyroid cancer. Endocrinol Metab Clin North Am. 24:761–801. 1995.
2	Muresan MM, Olivier P, Leclère J, et al: Bone metastases from differentiated thyroid carcinoma. Endocr Relat Cancer. 15:37–49. 2008. View Article : Google Scholar : PubMed/NCBI
3	Krishna L, Dadparvar S, Brady LW, et al: Paradoxical changes in iodine-131 scintigraphic findings in advanced follicular thyroid cancer. J Nucl Med. 34:1574–1576. 1993.PubMed/NCBI
4	Zuckier LS, Dohan O, Li Y, Chang CJ, Carrasco N and Dadachova E: Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate, and iodide by NaI symporter-expressing tissues in vivo. J Nucl Med. 45:500–507. 2004.PubMed/NCBI
5	Tian R, Kuang AR, Qin WS and Zhang HM: Value of post-therapy whole-body ¹³¹I scan in the evaluation of patients with differentiated thyroid cancer. Chin J Nucl Med. 20:162–164. 2000.(In Chinese).
6	Haugen BR and Lin EC: Isotope imaging for metastatic thyroid cancer. Endocrinol Metab Clin North Am. 30:469–492. 2001. View Article : Google Scholar : PubMed/NCBI
7	Mathiopoulou L, Chrisoulidou A, Boudina M, Mitsakis P, Mandanas S and Pazaitou-Panayiotou K: ^99mTc pertechnetate thyroid scan leads to serendipitous detection of metastatic thyroid cancer. Clin Nucl Med. 37:604–606. 2012. View Article : Google Scholar
8	Campbell CM and Khafagi FA: Insensitivity of Tc-99m pertechnetate for detecting metastases of differentiated thyroid carcinoma. Clin Nucl Med. 15:1–4. 1990. View Article : Google Scholar : PubMed/NCBI
9	Wang SS, Liang J, Lin YS and Yao RY: Differential expression of the Na symporter protein in thyroid cancer and adjacent normal and nodular goiter tissues. Oncol Lett. 5:368–372. 2012.PubMed/NCBI
10	Liou MJ, Lin JD, Chan EC, Liu FH, Chao TC and Weng HF: Detection of mRNA of sodium iodide symporter in benign and malignant human thyroid tissues. Cancer Lett. 160:75–80. 2000. View Article : Google Scholar : PubMed/NCBI
11	Peyrottes I, Navarro V, Ondo-Mendez A, et al: Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers. Eur J Endocrinol. 60:215–225. 2009.PubMed/NCBI
12	Summaria V, Rufini V, Mirk P, Costantini AM, Reale F and Maresca G: Diagnostic imaging of differentiated thyroid carcinoma. Rays. 25:177–190. 2000.(In English, Italian).
13	Krausz Y and Horne T: Detection of metastatic thyroid carcinoma by 99mTc-pertechnetate in the presence of hyperfunctioning thyroid tissue. J Surg Oncol. 44:132–134. 1990. View Article : Google Scholar : PubMed/NCBI
14	Kumaresan K and Sastry RA: Localization of Tc-99m pertechnetate in lymph node metastasis from occult thyroid carcinoma. Clin Nucl Med. 19:11121994. View Article : Google Scholar : PubMed/NCBI
15	Khan SU, Khan AU, Khan A, Shah AS and Khan K: Extrathyroidal uptake from thyroid carcinoma on ^99mTc-pertechnetate scintigraphy. J Coll Physicians Surg Pak. 21:772–774. 2011.PubMed/NCBI