Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest

  • Authors:
    • Yusong Zhang
    • Zhixiang Zhuang
    • Qinghui Meng
    • Yang Jiao
    • Jiaying Xu
    • Saijun Fan
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  • Published online on: November 21, 2013     https://doi.org/10.3892/ol.2013.1696
  • Pages: 295-301
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Abstract

Polydatin (PD), a small natural compound from Polygonum cuspidatum, has a number of biological functions. However, the anticancer activity of PD has been poorly investigated. In the present study, thiazolyl blue tetrazolium bromide assay was used to evaluate the inhibitory effect of PD on cell growth. Cell cycle distribution and apoptosis were investigated by flow cytometry. In addition, the expression of several proteins associated with apoptosis and cell cycle were analyzed by western blot analysis. The results demonstrated that PD significantly inhibits the proliferation of A549 and NCI‑H1975 lung cancer cell lines and causes dose‑dependent apoptosis. Cell cycle analysis revealed that PD induces S phase cell cycle arrest. Western blot analysis showed that the expression of Bcl‑2 decreased as that of Bax increased, and the expression of cyclin D1 was also suppressed. The results suggest that PD has potential therapeutic applications in the treatment of lung cancer.
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2014-January
Volume 7 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang Y, Zhuang Z, Meng Q, Jiao Y, Xu J and Fan S: Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. Oncol Lett 7: 295-301, 2014.
APA
Zhang, Y., Zhuang, Z., Meng, Q., Jiao, Y., Xu, J., & Fan, S. (2014). Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. Oncology Letters, 7, 295-301. https://doi.org/10.3892/ol.2013.1696
MLA
Zhang, Y., Zhuang, Z., Meng, Q., Jiao, Y., Xu, J., Fan, S."Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest". Oncology Letters 7.1 (2014): 295-301.
Chicago
Zhang, Y., Zhuang, Z., Meng, Q., Jiao, Y., Xu, J., Fan, S."Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest". Oncology Letters 7, no. 1 (2014): 295-301. https://doi.org/10.3892/ol.2013.1696